Pathophysiology of radiocontrast nephropathy: a role for medullary hypoxia.

Abstract:

:Recent experimental data underlies the role of hypoxic tubular injury in the pathophysiology of radiocontrast nephropathy. Although systemic transient hypoxemia, increased blood viscosity, and a leftward shift of the oxygen-hemoglobin dissociation curve may all contribute to intrarenal hypoxia, imbalance between oxygen demand and supply plays a major role in radiocontrast-induced outer medullary hypoxic damage. Low oxygen tension normally exists in this renal region, reflecting the precarious regional oxygen supply and a high local metabolic rate and oxygen requirement, resulting from active salt reabsorption by medullary thick ascending limbs of Henle's loop. Radiologic contrast agents markedly aggravate outer medullary physiologic hypoxia. This results from enhanced metabolic activity and oxygen consumption (as a result of osmotic diuresis and increased salt delivery to the distal nephron) because the regional blood flow and the oxygen supply actually increase. The latter effect may result in part from the activation of various regulatory mediators of outer medullary blood flow to ensure maximal regional oxygen supply. Low-osmolar radiocontrast agents may be less nephrotoxic because of the smaller osmotic load and vasomotor alterations. Experimental radiocontrast-induced renal failure requires preconditioning of animals with various insults (for example, congestive heart failure, reduced renal mass, salt depletion, or inhibition of nitric oxide and prostaglandin synthesis). In all these perturbations, which resemble clinical conditions that predispose to contrast nephropathy, outer medullary hypoxic injury results from insufficiency or inactivation of mechanisms designed to preserve regional oxygen balance. This underlines the importance of identifying and ameliorating predisposing factors in the prevention of this iatrogenic disease.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Heyman SN,Reichman J,Brezis M

doi

10.1097/00004424-199911000-00004

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

685-91

issue

11

eissn

0020-9996

issn

1536-0210

journal_volume

34

pub_type

杂志文章,评审
  • Gadobutrol-enhanced, three-dimensional, dynamic MR imaging with MR cholangiography for the preoperative evaluation of bile duct cancer.

    abstract:PURPOSE:To evaluate the diagnostic performance of 1.0-M gadobutrol-enhanced, 3-dimensional (3D), dynamic MR images with 3D-MR cholangiography (MRC) in the preoperative evaluation of bile duct cancer staging and resectability. MATERIALS AND METHODS:Our institutional review board approved this retrospective study. Sixty...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181d2eeb1

    authors: Ryoo I,Lee JM,Chung YE,Park HS,Kim SH,Han JK,Choi BI

    更新日期:2010-04-01 00:00:00

  • Systematic evaluation and increased structure in a radiology elective.

    abstract::Diagnostic radiology is expanding, playing an increasingly central role in patient care, which heightens the importance of radiology teaching in undergraduate medical education. This study examined the impact of increased structure and systematic evaluation on student performance in a radiology elective. The evaluatio...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198505000-00003

    authors: Blane CE,Calhoun JG,Maxim BR,Martel W,Davis WK

    更新日期:1985-05-01 00:00:00

  • Direct video-microscopic observation of the dynamic effects of medical ultrasound on ultrasound contrast microspheres.

    abstract:RATIONALE AND OBJECTIVES:Ultrasound can cause destruction of microbubble contrast agents used to enhance medical ultrasound imaging. This study sought to characterize the dynamics of this interaction by direct visual observation of microbubbles during insonification in vitro by a medical ultrasound imaging system. MET...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199812000-00004

    authors: Klibanov AL,Ferrara KW,Hughes MS,Wible JH Jr,Wojdyla JK,Dayton PA,Morgan KE,Brandenburger GH

    更新日期:1998-12-01 00:00:00

  • Some practical issues of experimental design and data analysis in radiological ROC studies.

    abstract::Receiver operating characteristic (ROC) analysis has been used in a broad variety of medical imaging studies during the past 15 years, and its advantages over more traditional measures of diagnostic performance are now clearly established. But despite the essential simplicity of the approach, workers in the field ofte...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198903000-00012

    authors: Metz CE

    更新日期:1989-03-01 00:00:00

  • Specific absorption rate as a poor indicator of magnetic resonance-related implant heating.

    abstract::Recent publications of the magnetic resonance safety profile of neurostimulators, cardiac pacemakers, and other implanted devices imply that these devices are no longer a contraindication for magnetic resonance imaging. It is very promising that patients who have these implanted devices may in the future no longer be ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000185898.59140.91

    authors: Nitz WR,Brinker G,Diehl D,Frese G

    更新日期:2005-12-01 00:00:00

  • The biliary and urinary excretion of sodium tyropanoate and sodium ipodate in dogs: pharmacokinetics, influence of bile salts and choleretic effects with comparison to iopanoic acid.

    abstract::The biliary and urinary excretion of sodium tyropanoate (Bilopaque) and sodium ipodate (Oragrafin) were studied in unanesthetized bile-fistula dogs using stepwise, increasing, intravenous infusions of the contrast materials. A constant intravenous infusion of sodium taurocholate was administered at the rate of either ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197701000-00017

    authors: Berk RN,Loeb PM,Cobo-Frenkel A,Barnhart JL

    更新日期:1977-01-01 00:00:00

  • Pyrroxamide, a nonionic nitroxyl spin label contrast agent for magnetic resonance imaging. Mutagenesis and cell survival.

    abstract::Pyrroxamide [N-(1-hydroxymethyl-2,3-dihydroxypropyl)-2,2,5,5-tetramethyl pyrrolidine-1-oxyl-3-carboxyamide] is a newly tested nonionic monomeric nitroxyl compound with demonstrated effectiveness for MRI contrast enhancement at doses as low as 10(-3) M. Pyrroxamide and its hydroxylamine metabolic derivative were tested...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198808000-00013

    authors: Gordon DG,Brasch RC,Ogan MD,Deen D

    更新日期:1988-08-01 00:00:00

  • Evaluation of the prostate imaging reporting and data system for the detection of prostate cancer by the results of targeted biopsy of the prostate.

    abstract:PURPOSE:The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for the detection of prostate cancer by the results of magnetic resonance imaging (MRI)-guided biopsy of the prostate as a reference standard. PATIENTS AND METHODS:In 55 patients who had underg...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000030

    authors: Baur AD,Maxeiner A,Franiel T,Kilic E,Huppertz A,Schwenke C,Hamm B,Durmus T

    更新日期:2014-06-01 00:00:00

  • Comparison of observer performance reading from a video CRT vs. reading from film.

    abstract::The developing trend for all medical images to be in digital form raises an important question: should diagnostic interpretations be made directly from a CRT or from some form of hard copy recording of the CRT? This question was studied by having two observers read a series of digital images of the thyroid including b...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198305000-00015

    authors: Keyes JW Jr,Kline RC,Resinger WW,Rose EA,Koral KF,Rogers WL

    更新日期:1983-05-01 00:00:00

  • Influence of paramagnetic ions and pH on proton NMR relaxation of biologic fluids.

    abstract::The extent to which various concentrations of the paramagnetic metal ions [gadolinium (III), manganese (II), chromium (III), iron (III), nickel (II), copper (II), and cobalt (II)] affect proton magnetic relaxation times of distilled water, 4% human serum albumin (HSA), and dog plasma was studied in vitro. The pH of wa...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198602000-00009

    authors: Barnhart JL,Berk RN

    更新日期:1986-02-01 00:00:00

  • Altered cerebrovenous drainage in patients with migraine as assessed by phase-contrast magnetic resonance imaging.

    abstract:OBJECTIVE:We aimed to assess whether migraine is associated with changes in the distribution of the venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI). METHODS:We examined 26 patients (37.3 ± 13.9 years) with recurring migraine headaches and 26 age- and gend...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e318210ecf5

    authors: Koerte IK,Schankin CJ,Immler S,Lee S,Laubender RP,Grosse C,Eftimov L,Milde-Busch A,Reiser M,Straube A,Heinen F,Alperin N,Ertl-Wagner B

    更新日期:2011-07-01 00:00:00

  • Magnetic resonance imaging using gadolinium labeled monoclonal antibody.

    abstract::Gadolinium was attached to antibodies and tested in vitro and in vivo for its effect on proton relaxation enhancement. Using the cyclic anhydride method, diethylenetriaminepentaacetic acid (DTPA) was attached to albumin, IgG and anti-CEA monoclonal antibody. Gadolinium (Gd) was then chelated to the protein complexes f...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198510000-00008

    authors: Unger EC,Totty WG,Neufeld DM,Otsuka FL,Murphy WA,Welch MS,Connett JM,Philpott GW

    更新日期:1985-10-01 00:00:00

  • Magnetic resonance angiography in infrapopliteal arterial disease: prospective comparison of 1.5 and 3 Tesla magnetic resonance imaging.

    abstract:PURPOSE:To prospectively determine the accuracy of 1.5 Tesla (T) and 3 T magnetic resonance angiography (MRA) versus digital subtraction angiography (DSA) in the depiction of infrageniculate arteries in patients with symptomatic peripheral arterial disease. PATIENTS AND METHODS:A prospective 1.5 T, 3 T MRA, and DSA co...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000262581.52315.ef

    authors: Diehm N,Kickuth R,Baumgartner I,Srivastav SK,Gretener S,Husmann MJ,Jaccard Y,Do do D,Triller J,Bonel HM

    更新日期:2007-06-01 00:00:00

  • Interference of gadolinium-containing contrast-enhancing agents with colorimetric calcium laboratory testing.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the extent to which various commercially available gadolinium-containing contrast-enhancing (CE) agents can interfere with the measurement of calcium levels by currently used laboratory methods, suggesting (spurious) hypocalcemia or hypercalcemia with a potential ris...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000170447.45577.5e

    authors: Löwe A,Balzer T,Hirt U

    更新日期:2005-08-01 00:00:00

  • Air-filled ultrasound contrast agents do not damage the cerebral microvasculature or brain tissue in rats.

    abstract:RATIONALE AND OBJECTIVES:Air microemboli may damage the cerebral microvasculature. The aim of this study was to evaluate the safety of ultrasound contrast agents composed of air microspheres with regard to cerebral damage when administered into the arterial system (ie, when not filtered by the capillary system of the l...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199803000-00001

    authors: Haggag KJ,Russell D,Walday P,Skiphamn A,Torvik A

    更新日期:1998-03-01 00:00:00

  • Time continuous tracking and segmentation of cardiovascular magnetic resonance images using multidimensional dynamic programming.

    abstract::In this article, we propose a semiautomatic method for time-continuous contour detection in all phases of the cardiac cycle in magnetic resonance sequences. The method is based on multidimensional dynamic programming. After shape parameterization, cost hypercubes are filled with image-feature derived cost function val...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000194070.88432.24

    authors: Uzümcü M,van der Geest RJ,Swingen C,Reiber JH,Lelieveldt BP

    更新日期:2006-01-01 00:00:00

  • Can Ferumoxytol be Used as a Contrast Agent to Differentiate Between Acute and Chronic Inflammatory Kidney Disease?: Feasibility Study in a Rat Model.

    abstract:OBJECTIVES:Ferumoxytol, an intravenous iron supplement, can be used in off-label mode as a contrast agent in magnetic resonance imaging. The aim of this study was to assess whether ferumoxytol can be used as a marker of inflammation in animal models of acute and chronic inflammatory kidney diseases. MATERIAL AND METHO...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000209

    authors: Budjan J,Neudecker S,Schock-Kusch D,Kraenzlin B,Schoenberg SO,Michaely HJ,Attenberger UI

    更新日期:2016-02-01 00:00:00

  • Improving CT-Based PET Attenuation Correction in the Vicinity of Metal Implants by an Iterative Metal Artifact Reduction Algorithm of CT Data and Its Comparison to Dual-Energy-Based Strategies: A Phantom Study.

    abstract:OBJECTIVE:The aim of this study was to evaluate the potential of iterative metal artifact reduction (IMAR) for the improvement of computed tomography (CT)-based position emission tomography (PET) attenuation correction in the vicinity of metal implants and compare it with dual-energy-based metal artifact reduction stra...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000306

    authors: Schabel C,Gatidis S,Bongers M,Hüttig F,Bier G,Kupferschlaeger J,Bamberg F,la Fougère C,Nikolaou K,Pfannenberg C

    更新日期:2017-01-01 00:00:00

  • Systolic flow displacement correlates with future ascending aortic growth in patients with bicuspid aortic valves undergoing magnetic resonance surveillance.

    abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000064

    authors: Burris NS,Sigovan M,Knauer HA,Tseng EE,Saloner D,Hope MD

    更新日期:2014-10-01 00:00:00

  • Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility.

    abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000638

    authors: Burkhardt C,Tzschätzsch H,Schmuck R,Bahra M,Jürgensen C,Pelzer U,Hamm B,Braun J,Sack I,Marticorena Garcia SR

    更新日期:2020-05-01 00:00:00

  • Ultrasonic detection of osteomyelitis. Pathologic correlation in an animal model.

    abstract::The authors correlated sonographic findings with histologic findings in a rabbit model of osteomyelitis. Staphylococcus aureus osteomyelitis was induced in the femora of 11 New Zealand white rabbits. The opposite leg was used as a control. Sonographic findings showed fluid adjacent to the bone in 11 cases. The fluid w...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199202000-00002

    authors: Abiri MM,DeAngelis GA,Kirpekar M,Abou AN,Ablow RC

    更新日期:1992-02-01 00:00:00

  • Diffusion Tensor Imaging of Healthy Skeletal Muscles: A Comparison Between 7 T and 3 T.

    abstract:OBJECTIVE:The aim of this study was to assess and compare the overall performance, reliability, variability, as well as the accuracy of diffusion tensor imaging (DTI) and fiber tracking metrics, for the muscles of the calf at 3 T and 7 T. MATERIALS AND METHODS:Ten volunteers (5 males; mean age, 29.1 ± 4.7 years), with...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000508

    authors: Giraudo C,Motyka S,Weber M,Feiweier T,Trattnig S,Bogner W

    更新日期:2019-01-01 00:00:00

  • Evaluation of diffusion-weighted MR imaging at inclusion in an active surveillance protocol for low-risk prostate cancer.

    abstract:PURPOSE:We aimed to determine whether diffusion-weighted magnetic resonance imaging, by means of the apparent diffusion coefficient (ADC), is able to guide magnetic resonance-guided biopsy in patients fit for active surveillance (AS) and identify patients harboring high-grade Gleason components not suitable for AS. MA...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31827b711e

    authors: Somford DM,Hoeks CM,Hulsbergen-van de Kaa CA,Hambrock T,Fütterer JJ,Witjes JA,Bangma CH,Vergunst H,Smits GA,Oddens JR,van Oort IM,Barentsz JO,MR-PRIAS Collaboration Group.

    更新日期:2013-03-01 00:00:00

  • Free-breathing three-dimensional computed tomography of the lung using prospective respiratory gating: charge-coupled device camera and laser sensor device in an animal experiment.

    abstract:PURPOSE:The aim was to investigate the feasibility and image quality of prospective respiratory gating for 3-D computed tomography (CT) of the lung. MATERIAL AND METHODS:Eight anesthetized pigs underwent prospectively gated multidetector computed tomography using 2 devices: a charge-coupled device (CCD) camera and a l...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000208926.98693.b6

    authors: Zaporozhan J,Ley S,Unterhinninghofen R,Saito Y,Fabel-Schulte M,Keller S,Szabo G,Kauczor HU

    更新日期:2006-05-01 00:00:00

  • Facilitated Diagnosis of Pneumothoraces in Newborn Mice Using X-ray Dark-Field Radiography.

    abstract:OBJECTIVE:The aim of this study was to evaluate the diagnostic value of x-ray dark-field imaging in projection radiography-based depiction of pneumothoraces in the neonatal murine lung, a potentially life-threatening medical condition that requires a timely and correct diagnosis. MATERIALS AND METHODS:By the use of a ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000285

    authors: Hellbach K,Yaroshenko A,Willer K,Pritzke T,Baumann A,Hesse N,Auweter S,Reiser MF,Eickelberg O,Pfeiffer F,Hilgendorff A,Meinel FG

    更新日期:2016-10-01 00:00:00

  • Adenosine-stress dynamic myocardial CT perfusion imaging: initial clinical experience.

    abstract:OBJECTIVE:To evaluate the feasibility of adenosine-stress dynamic myocardial volume perfusion imaging with second generation dual source computed tomography (CT) for the qualitative and quantitative assessment of myocardial blood flow (MBF) compared with stress perfusion and viability magnetic resonance imaging (MRI). ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181dfa2f2

    authors: Bastarrika G,Ramos-Duran L,Rosenblum MA,Kang DK,Rowe GW,Schoepf UJ

    更新日期:2010-06-01 00:00:00

  • The effect of computed tomographic scan orientation on information loss in the three-dimensional reconstruction of tripod zygomatic fractures.

    abstract::Fractures modeled in the dried skull indicate that the initial plane of computed tomography (CT) section contributes to the accuracy of three-dimensional (3D) images generated from two-dimensional (2D) CT data. The authors retrospectively analyzed seven clinical cases of tripod zygomatic fractures that were imaged wit...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199105000-00009

    authors: Levy RA,Kellman RM,Rosenbaum AE

    更新日期:1991-05-01 00:00:00

  • Fibroblast response to gadolinium: role for platelet-derived growth factor receptor.

    abstract:OBJECTIVE:The purpose of this study was to assess the effects of gadolinium (Gd3+), provided as gadolinium chloride, on fibroblast function. MATERIALS AND METHODS:Human dermal fibroblasts in monolayer culture and intact skin in organ culture were exposed to the lanthanide metal (1-20 μM). RESULTS:Increased proliferat...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181e943d2

    authors: Bhagavathula N,Dame MK,DaSilva M,Jenkins W,Aslam MN,Perone P,Varani J

    更新日期:2010-12-01 00:00:00

  • Increased ablation zones using a cryo-based internally cooled bipolar RF applicator in ex vivo bovine liver.

    abstract:PURPOSE:To evaluate the feasibility of ex vivo ablation implementing a cryo-based internally cooled bipolar radiofrequency (RF) applicator and to determine the influence of power and gas pressure on the size and shape of the resulting ablation zones. MATERIALS AND METHODS:Two hundred twenty-five ablations were perform...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3181b66d11

    authors: Rempp H,Voigtländer M,Clasen S,Kempf S,Neugebauer A,Schraml C,Schmidt D,Claussen CD,Enderle MD,Goldberg SN,Pereira PL

    更新日期:2009-12-01 00:00:00

  • Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.

    abstract:RATIONALE AND OBJECTIVES:To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model. MATERIALS AND METHODS:Fourteen cats were prepared for acute myocardial infarction with 90-minute...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: Kim TH,Yang DH,Choi JW,Kim ST,Yoon JH,Shin JH,Seo JB,Gong GY,Lim TH

    更新日期:2005-01-01 00:00:00