Alteration of human tumor cell adhesion by high-strength static magnetic fields.

Abstract:

RATIONALE AND OBJECTIVES:The authors investigated whether the ability of human malignant melanoma cells to increase in cell number or their ability to remain viable was compromised by high-field strength static magnetic fields. Normal human fibroblasts also were studied to determine if any magnetic field-related alterations were unique to tumor populations. METHODS:Human cell lines were grown in monolayer culture in vitro and subjected to a static magnetic field using a 4.7-Tesla superconducting magnetic resonance imaging (MRI) magnet with the gradient coils removed. The number of cells within the total population was determined using an electronic particle counter. Cell viability was estimated by trypan blue exclusion, and the cellular morphology of the attached cells was documented using microscopy. RESULTS:Both the human malignant melanoma cells and the normal human cells were unaffected by the presence of a high-strength magnetic field in terms of increasing their cell numbers or their viability. However, the ability of the malignant melanoma cells to remain attached to the tissue culture surface was impaired. Normal fibroblasts were not affected in this regard. CONCLUSION:High-strength static magnetic fields alter the ability of human malignant melanoma cells to remain adherent to the tissue culture surface, but have no effect on normal human fibroblasts. This may affect the ability of tumor cells to successfully interact with their environment.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Short WO,Goodwill L,Taylor CW,Job C,Arthur ME,Cress AE

doi

10.1097/00004424-199210000-00014

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

836-40

issue

10

eissn

0020-9996

issn

1536-0210

journal_volume

27

pub_type

杂志文章
  • Contrast and electrolyte dynamics of the intravenous pyelogram. II. Disparities in serum and urine concentrations of meglumine and anion.

    abstract::Intravenous or intra-aortic injections of meglumine iothalamate in dogs indicate a slightly different tissue distribution and excretory pattern of the meglumine cation and the iothalamate anion. Differences in serum and urinary concentrations of these ions suggest some cellular penetration of the meglumine anion. In a...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197507000-00004

    authors: Lasser EC,Lang JH,Hamblin AE,Rosen L

    更新日期:1975-07-01 00:00:00

  • Long-term effect of irradiation on lymph node uptake of interstitially delivered nanoparticulate contrast media.

    abstract:RATIONALE AND OBJECTIVES:To characterize the long-term effects of therapeutic doses of ionizing radiation on the uptake and distribution of percutaneously delivered particulate contrast media in normal lymph nodes. METHODS:Two milliliters of an iodinated nanoparticle suspension (76 mg I/mL) was injected subcutaneously...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200003000-00007

    authors: Wisner ER,Théon A,Griffey SM,McIntire GL

    更新日期:2000-03-01 00:00:00

  • Effect of multiple intravenous injections of diatrizoate on iodine concentrations and osmolality. An experimental study in rabbits.

    abstract::Multiple intravenous injections of contrast media are used in radiology, but information regarding corresponding changes in the serum iodine concentrations and osmolality is lacking. We measured the changes in serum iodine concentration and serum osmolality in rabbits after a series of intravenous injections of contra...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198703000-00007

    authors: Rubin DI,Kido DK,Morris TW,Fischer HW

    更新日期:1987-03-01 00:00:00

  • Continuous Hepatic Arterial Multiphase Magnetic Resonance Imaging During Free-Breathing.

    abstract:PURPOSE:The aim of this study was to evaluate the feasibility of a prototype volume-interpolated breath-hold examination (VIBE) sequence using compressed sensing (VIBECS) for rapid multiphase arterial magnetic resonance imaging (MRI) at different temporal resolution during free-breathing in comparison with a convention...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000459

    authors: Weiss J,Notohamiprodjo M,Taron J,Martirosian P,Nickel D,Bamberg F,Nikolaou K,Othman AE

    更新日期:2018-10-01 00:00:00

  • Dynamic contrast-enhanced ultrasound for assessment of skeletal muscle microcirculation in peripheral arterial disease.

    abstract:OBJECTIVE:: This feasibility study was performed to assess whether dynamic contrast-enhanced ultrasound (CEUS) and transient arterial occlusion are able to detect alterations in the microvascular perfusion and arterial perfusion reserve in patients suffering from peripheral arterial disease (PAD) in comparison with hea...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e3182183a77

    authors: Amarteifio E,Weber MA,Wormsbecher S,Demirel S,Krakowski-Roosen H,Jöres A,Braun S,Delorme S,Böckler D,Kauczor HU,Krix M

    更新日期:2011-08-01 00:00:00

  • The pediatric tracheostomy: III). An appraisal of xerography.

    abstract::Comparatively new in the roentgen evaluation of infants and children, xerography would appear to be ideal for portraying the pediatric airway. Since the radiation dose of xerography is higher than conventional radiography, its image quality is the subject of careful scrutiny in a pediatric setting here described in 23...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-197807000-00002

    authors: Scott JR,Kramer SS,Griscom NT

    更新日期:1978-07-01 00:00:00

  • Quantification of Aortic Stiffness by Ultrasound Time-Harmonic Elastography: The Effect of Intravascular Pressure on Elasticity Measures in a Porcine Model.

    abstract:OBJECTIVES:The aim of this study was to investigate blood pressure dependency of ultrasound time-harmonic elastography (THE) for quantification of aortic stiffness. MATERIALS AND METHODS:Thoracoabdominal aortas were surgically removed from 9 healthy domestic pigs and prepared for elastographic experiments. All vessels...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000618

    authors: Schaafs LA,Tzschätzsch H,Steffen IG,Braun J,Hamm B,Sack I,Elgeti T

    更新日期:2020-03-01 00:00:00

  • Magnetic resonance imaging as a monitor of changes in the irradiated rat brain. An aid in determining the time course of events in a histologic study.

    abstract:RATIONALE AND OBJECTIVES:Optimal dose schedules and total dose of ionizing radiation for human central nervous system malignancy are not known. An animal model has been developed for the investigation of rat central nervous system response to proton irradiation using magnetic resonance imaging (MRI). A clinical MRI dev...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199504000-00003

    authors: Kennedy AS,Archambeau JO,Archambeau MH,Holshouser B,Thompson J,Moyers M,Hinshaw D Jr,Slater JM

    更新日期:1995-04-01 00:00:00

  • Magnetization transfer and high-dose contrast in early brain infection on magnetic resonance.

    abstract:RATIONALE AND OBJECTIVES:The authors studied the effect of contrast dose, use of magnetization transfer (MT), and temporal delay on the visualization of contrast enhancement with gadoteridol (Gd HP-DO3A) in a canine brain abscess model. METHODS:Alpha streptococcus brain abscesses were studied in five dogs at 1.5 tesla...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199503000-00001

    authors: Runge VM,Wells JW,Kirsch JE

    更新日期:1995-03-01 00:00:00

  • Development of a macromolecular dual-modality MR-optical imaging for sentinel lymph node mapping.

    abstract:OBJECTIVE:To evaluate the effectiveness of a dual magnetic resonance-near infrared fluorescence optical imaging agent, poly(l-glutamic acid)-DTPA-Gd-NIR813, for both preoperative and intraoperative visualization and characterization of sentinel lymph nodes (SLN) in mice. MATERIALS AND METHODS:Poly(L-glutamic acid) was...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0b013e31804f5a79

    authors: Melancon MP,Wang Y,Wen X,Bankson JA,Stephens LC,Jasser S,Gelovani JG,Myers JN,Li C

    更新日期:2007-08-01 00:00:00

  • Comparative evaluation of digital radiography versus conventional radiography of fractured skulls.

    abstract:OBJECTIVES:The authors assessed the relative efficacy of conventional and digital storage-phosphor radiographs for the detection of skull fractures. METHODS:Fifty conventional film-screen radiographs (FSR) and 50 digital storage-phosphor radiographs (DR) with 66 fractures were compared. Five radiologists evaluated ima...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199308000-00005

    authors: Langen HJ,Klein HM,Wein B,Stargardt A,Günther RW

    更新日期:1993-08-01 00:00:00

  • The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.

    abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198507000-00009

    authors: Dae M,Canhasi B,Botvinick E,Olvera S,Schechtmann N,Engelstad B,Hattner R,Schiller N,O'Connell W,Faulkner D

    更新日期:1985-07-01 00:00:00

  • Magnetic resonance imaging of acute myocardial infarction using a nitroxyl spin label (PCA).

    abstract::The effects of an intravenously administered nitroxyl spin label (PCA) on the magnetic resonance imaging (MRI) appearance and relaxation times of acute canine myocardial infarctions were studied. Twenty-four hours after ligation of the left anterior descending coronary artery (LAD), animals were either sacrificed imme...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:

    authors: McNamara MT,Wesbey GE,Brasch RC,Sievers R,Lipton MJ,Higgins CB

    更新日期:1985-09-01 00:00:00

  • Multiplanar reconstruction in magnetic resonance evaluation of the knee. Comparison with film magnetic resonance interpretation.

    abstract:RATIONALE AND OBJECTIVES:At many institutions, three-dimensional magnetic resonance imaging (MRI) is routinely used for examination of the knee. Multiplanar reconstruction (MPR) is a method of displaying three-dimensional datasets. The authors assessed the usefulness of MPR for evaluating knee MRI datasets by comparing...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199302000-00011

    authors: Gay SB,Chen NC,Burch JJ,Gleason TR,Sagman AM

    更新日期:1993-02-01 00:00:00

  • Structured Reporting of Rectal Magnetic Resonance Imaging in Suspected Primary Rectal Cancer: Potential Benefits for Surgical Planning and Interdisciplinary Communication.

    abstract:OBJECTIVES:The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000336

    authors: Nörenberg D,Sommer WH,Thasler W,DʼHaese J,Rentsch M,Kolben T,Schreyer A,Rist C,Reiser M,Armbruster M

    更新日期:2017-04-01 00:00:00

  • Heavily Calcified Coronary Arteries: Advanced Calcium Subtraction Improves Luminal Visualization and Diagnostic Confidence in Dual-Energy Coronary Computed Tomography Angiography.

    abstract:OBJECTIVES:The aim of this study was to evaluate a prototype dual-energy computed tomography calcium subtraction algorithm and its impact on luminal visualization in patients with heavily calcified coronary arteries. MATERIALS AND METHODS:Twenty-nine patients (62% male; mean age, 64 ± 7 years) who had undergone dual-e...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000416

    authors: De Santis D,Jin KN,Schoepf UJ,Grant KL,De Cecco CN,Nance JW Jr,Vogl TJ,Laghi A,Albrecht MH

    更新日期:2018-02-01 00:00:00

  • Ultrasound Time-Harmonic Elastography of the Pancreas: Reference Values and Clinical Feasibility.

    abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/RLI.0000000000000638

    authors: Burkhardt C,Tzschätzsch H,Schmuck R,Bahra M,Jürgensen C,Pelzer U,Hamm B,Braun J,Sack I,Marticorena Garcia SR

    更新日期:2020-05-01 00:00:00

  • Pyelovenous and pyelolymphatic backflow during retrograde pyelography in renal vein thrombosis.

    abstract::Pyelovenous and pyelolymphatic backflow have been observed during retrograde pyelography in three patients with renal vein thrombosis. The radiographic patterns of backflow following experimental unilateral renal vein occlusion in rabbits were analyzed and correlated with the clinical findings. Capsular, perihilar, pe...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198101000-00003

    authors: Bidgood WD Jr,Cuttino JT Jr,Clark RL,Volberg FM

    更新日期:1981-01-01 00:00:00

  • Multislice CT angiography of the iliac arteries in the presence of various stents: in vitro evaluation of artifacts and lumen visibility.

    abstract:RATIONALE AND OBJECTIVES:To evaluate the imaging characteristics of various iliac artery stents and stent-grafts in a multislice, computed tomography angiography (MSCTA) phantom study. METHODS:Twelve types of stents and three stent-grafts made of different materials (steel, nitinol, tantalum, cobalt-based alloy) were ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200112000-00004

    authors: Maintz D,Fischbach R,Juergens KU,Allkemper T,Wessling J,Heindel W

    更新日期:2001-12-01 00:00:00

  • Comparison of gadobenate dimeglumine with gadopentetate dimeglumine for magnetic resonance imaging of liver tumors.

    abstract:RATIONALE AND OBJECTIVES:To compare gadobenate dimeglumine (Gd-BOPTA) with gadopentetate dimeglumine (Gd-DTPA) for magnetic resonance imaging of the liver. METHODS:The contrast agent Gd-BOPTA or Gd-DTPA was administered at a dose of 0.1 mmol/kg to 257 patients suspected of having malignant liver tumors. Dynamic phase ...

    journal_title:Investigative radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004424-200111000-00002

    authors: Kuwatsuru R,Kadoya M,Ohtomo K,Tanimoto A,Hirohashi S,Murakami T,Tanaka Y,Yoshikawa K,Katayama H

    更新日期:2001-11-01 00:00:00

  • Thoracic metastases from cervical carcinoma: current status.

    abstract::Thoracic metastases from squamous carcinoma and adenocarcinoma of the cervix were studied by reviewing 245 consecutive cases to describe comparative incidence, natural history, and radiographic patterns. The incidence of chest metastases was higher for adenocarcinoma (20%) than for squamous carcinoma (4%). Few patient...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198003000-00004

    authors: Sostman HD,Matthay RA

    更新日期:1980-03-01 00:00:00

  • Intracranial arteriovenous malformations. Current imaging and treatment.

    abstract::Patients with intracranial arteriovenous malformations (AVM) can expect significant mortality (15% to 20%) and morbidity (20% to 30%) over a 15-year to 20-year period. Recent advances in interventional neuroradiology, neurosurgery, neuroanesthesia, and stereotactic radiotherapy provide the opportunity to obliterate ma...

    journal_title:Investigative radiology

    pub_type: 杂志文章,评审

    doi:10.1097/00004424-199008000-00014

    authors: Graves VB,Duff TA

    更新日期:1990-08-01 00:00:00

  • Effect of intraarticular pressure on patellar position. Computed tomography study in cadaveric specimens.

    abstract:RATIONALE AND OBJECTIVES:The purpose of the study was to evaluate the effect of articular fluid distention on patellar position at different degrees of knee angulation. METHODS:Patellar position in 10 cadaveric knee specimens was determined with 30, 100, and 200 mm Hg joint distention at 45, 20, and 5 degrees of knee ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199602000-00001

    authors: Brossmann J,Koch S,Schwarzenberg H,Link J,Muhle C,Bull CC,Heller M

    更新日期:1996-02-01 00:00:00

  • Development, chemistry, and physical properties of iopamidol and its analogues.

    abstract::A series of 5-hydroxyacylamino-2,4,6-triiodo-N,N'-hydroxy-alkyl-isophtalamides was prepared in order to study the structural requirements for high water solubility and low toxicity. Among the amides substituted by 2-hydroxyethyl; 2,3-dihydroxypropyl; 1,3-dihydroxypropyl-; and 1,1-dihydroxy-methyl-2-oxyethyl- groups, t...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198011001-00065

    authors: Pitrè D,Felder E

    更新日期:1980-11-01 00:00:00

  • The effects of orientation on volume measurements of human left ventricular casts.

    abstract::Biplane angiocardiography has emerged as a standard method for calculating left ventricular volume measurements. Validation of such measurements has separately been made for several projections of silicone casts of the left ventricle. This study was undertaken to establish and compare the regression lines for left ven...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-198011000-00002

    authors: Lipton MJ,Hayashi TT,Davis PL,Carlsson E

    更新日期:1980-11-01 00:00:00

  • The mini-fellowship in teaching. A senior resident elective.

    abstract::The residency program at the University of Pennsylvania offers a 1-month fellowship for senior residents in medical student education. Instructional philosophy, methods, and content are discussed, observed, practiced, and evaluated. Close supervision and immediate feedback provide training particularly needed by futur...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-199006000-00028

    authors: Troupin RH

    更新日期:1990-06-01 00:00:00

  • Visualization of breast lymphatic pathways with an indirect computed tomography lymphography using a nonionic monometric contrast medium iopamidol: preliminary results.

    abstract:RATIONALE AND OBJECTIVES:The capability of an indirect computed tomographic lymphography (CT-LG) using a nonionic monometric contrast medium iopamidol for visualizing breast lymphatic pathways was preliminarily tested. MATERIALS AND METHODS:In 10 female dogs, a total of 0.5 and 1 mL of undiluted iopamidol was injected...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200302000-00002

    authors: Suga K,Ogasawara N,Yuan Y,Okada M,Matsunaga N,Tangoku A

    更新日期:2003-02-01 00:00:00

  • Human brain chemical shift imaging at age 60 to 90: analysis of the causes of the observed sex differences in brain metabolites.

    abstract:RATIONALE AND OBJECTIVES:To assess whether differences in cerebral atrophy and white matter lesions or in the presence of lactate and lipid signals can explain the observed differences in brain choline, creatine, and N-acetylaspartate levels between healthy elderly women and men. METHODS:In addition to standard magnet...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200110000-00005

    authors: Sijens PE,Den Heijer T,De Leeuw FE,De Groot JC,Achten E,Heijboer RJ,Hofman A,Breteler MM,Oudkerk M

    更新日期:2001-10-01 00:00:00

  • Effect of transcatheter hepatic arterial embolization on angiogenesis in an animal model.

    abstract:OBJECTIVES:Transcatheter arterial embolization (TAE) is used for the treatment of patients with malignant liver tumors. However, the proangiogenesis effect of TAE-associated hypoxia has not been adequately studied. The goal of this study was to determine angiogenic activity in tumors subjected to TAE by evaluating the ...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/01.rli.0000209663.00629.8a

    authors: Gupta S,Kobayashi S,Phongkitkarun S,Broemeling LD,Kan Z

    更新日期:2006-06-01 00:00:00

  • Antiproliferative effects of the antiallergic agent azelastine on human aortic smooth-muscle cells: an in vitro study.

    abstract:RATIONALE AND OBJECTIVES:The aim of the study was to examine the effects of azelastine on proliferation, clonogenic activity, cell-cycle, and migration of human aortic smooth-muscle cells (haSMCs) in vitro. METHODS:HaSMCs were treated for 4 days with azelastine (1 micromol/L, 25 micromol/L, 50 micromol/L). Half of the...

    journal_title:Investigative radiology

    pub_type: 杂志文章

    doi:10.1097/00004424-200205000-00002

    authors: Schöber W,Wiskirchen J,Kehlbach R,Gebert R,Rodegerdts E,Betsch A,Johst U,Feuls R,Claussen CD,Duda SD

    更新日期:2002-05-01 00:00:00