Abstract:
RATIONALE AND OBJECTIVES:To assess whether differences in cerebral atrophy and white matter lesions or in the presence of lactate and lipid signals can explain the observed differences in brain choline, creatine, and N-acetylaspartate levels between healthy elderly women and men. METHODS:In addition to standard magnetic resonance imaging of the brain, an 8 x 8 x 2-cm3 supraventricular transverse brain volume parallel to the canthomeatal line was examined by magnetic resonance spectroscopy (automated 1H chemical shift imaging) in 540 healthy elderly persons. RESULTS:At P = 0.01, 0.001, and 0.0001, choline differed between women and men in 14, 9, and 5 of 36 voxels, respectively. On correction for cerebral atrophy (more frequent in men than in women), white matter lesions (more frequent in women), and lactate and lipid (more frequent in women), the differences in choline were reduced to 13, 6, and 3. Sex differences for creatine and N-acetylaspartate were similar but less numerous after correction. CONCLUSIONS:Elderly women and men in the general population show differences in the levels of creatine, N-acetylaspartate, and especially choline in portions of the brain. The sex-related differences in brain metabolite levels cannot be explained by differences in cerebral atrophy or other aging-related phenomena (white matter lesions, lactate, lipid).
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Sijens PE,Den Heijer T,De Leeuw FE,De Groot JC,Achten E,Heijboer RJ,Hofman A,Breteler MM,Oudkerk Mdoi
10.1097/00004424-200110000-00005keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
597-603issue
10eissn
0020-9996issn
1536-0210journal_volume
36pub_type
杂志文章abstract:OBJECTIVES:The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000484
更新日期:2018-11-01 00:00:00
abstract::Twenty-six patients who had received 43 grafts were studied before and after coronary artery vein bypass surgery. Cine ventriculograms taken in the right anterior oblique projection were analyzed and regional ejection fractions calculated. Single and multiple grafts were considered separately as were thrombosed and pa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197705000-00001
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abstract:OBJECTIVE:There is little published information regarding the efficacy of paclitaxel-coated balloon catheters except for the iopromide-containing formulation, and less is known about the kind of toxicity at overdose. The aim of our study was to assess 2 different paclitaxel matrix formulations on angioplasty balloon ca...
journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e31820577df
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess whether the recently developed method of grating-based x-ray dark-field radiography can improve the diagnosis of pulmonary emphysema in vivo. MATERIALS AND METHODS:Pulmonary emphysema was induced in female C57BL/6N mice using endotracheal instillation of porcine pancr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000067
更新日期:2014-10-01 00:00:00
abstract::Multiple intravenous injections of contrast media are used in radiology, but information regarding corresponding changes in the serum iodine concentrations and osmolality is lacking. We measured the changes in serum iodine concentration and serum osmolality in rabbits after a series of intravenous injections of contra...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198703000-00007
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abstract:INTRODUCTION:The aim of the present study was to evaluate the potential of high-resolution MRI at 2 Tesla (T) for direct noninvasive imaging of the aortic wall in a mouse model of atherosclerosis. MATERIAL AND METHODS:A specific mouse antenna was developed and sequence parameters were adjusted. T(1)- and T2-weighted i...
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更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:Imaging of the kidney using blood oxygen level dependent MR presents a major opportunity to examine differences in tissue oxygenation within the cortex and medulla applicable to human disease. We sought to define the differences between regions within kidneys and to optimize selection of regions of interest ...
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journal_title:Investigative radiology
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doi:10.1097/00004424-198501000-00014
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doi:10.1097/00004424-199003000-00006
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199603000-00003
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pub_type: 杂志文章
doi:10.1097/00004424-199402000-00017
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journal_title:Investigative radiology
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doi:10.1097/00004424-199002000-00008
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doi:10.1097/00004424-199904000-00005
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journal_title:Investigative radiology
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doi:10.1097/00004424-199905000-00007
更新日期:1999-05-01 00:00:00
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journal_title:Investigative radiology
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doi:10.1097/00004424-199408000-00009
更新日期:1994-08-01 00:00:00
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更新日期:2008-11-01 00:00:00
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更新日期:1993-02-01 00:00:00
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更新日期:1987-04-01 00:00:00
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journal_title:Investigative radiology
pub_type: 杂志文章
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