Abstract:
PURPOSE:The purpose of this study was to assess the value of intravoxel incoherent motion and diffusion-weighted imaging for predicting the histologic grade of pancreatic neuroendocrine tumors (PNETs). MATERIALS AND METHODS:Forty patients with surgically diagnosed PNETs who underwent preoperative magnetic resonance imaging, including diffusion-weighted imaging with a series of 10 b values (0-1000 s/mm(2), were included in this institutional review board-approved retrospective study. The apparent diffusion coefficient (ADC(total)), the intravoxel incoherent motion parameters (pure diffusion coefficient [D], pseudodiffusion coefficient [D(*)], and perfusion fraction [f]) were measured on the tumors. Histologic grading was performed on the basis of the World Health Organization 2010 classification system. Logistic regression analysis and receiver operating curve analysis were performed to identify the significant factors predicting the histologic grades. RESULTS:Grades 2 and 3 tumors were significantly larger than grade 1 tumors (average 3.62 cm vs 2.17 cm in diameter; P=0.001). Grades 2 and 3 tumors showed significantly lower D values than did grade 1 tumors (0.95 vs 1.21×10(-3) mm(2)/s; P=0.009), although the ADC(total) showed no significant difference. When any of the following 2 criteria was used, (a) tumor size smaller than 2.0 cm in diameter and (b) D value greater than 1.2×10(-3) mm(2)/s, the sensitivity, specificity, and positive predictive value for diagnosing grade 1 PNETs were 76.92%, 100%, and 100%, respectively. CONCLUSIONS:Pure diffusion coefficient (D) is possibly a better marker than ADC(total) is for differentiating grade 1 from grade 2 or 3 PNET and, combined with tumor size, can predict grade 1 PNET with a high specificity.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Hwang EJ,Lee JM,Yoon JH,Kim JH,Han JK,Choi BI,Lee KB,Jang JY,Kim SW,Nickel MD,Kiefer Bdoi
10.1097/RLI.0000000000000028subject
Has Abstractpub_date
2014-06-01 00:00:00pages
396-402issue
6eissn
0020-9996issn
1536-0210journal_volume
49pub_type
杂志文章abstract::Due to the nature of three-dimensional Fourier transform (3-DFT) data acquisition in magnetic resonance imaging (MRI), the spatial relation between a resolved volume element (a voxel) and the object can be manipulated easily. Those manipulations have practical consequences in terms of registering slice positions with ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199012000-00006
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare quantitative and semiquantitative parameters (signal-to-noise ratio [SNR], contrast-to-noise ratio [CNR], image quality, diagnostic confidence) from a standard brain magnetic resonance imaging examination encompassing common neurological disorders such as demyelinating dis...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000256
更新日期:2016-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors investigate whether a modified gadolinium (Gd)-DTPA formulation can be aerosolized and used as a contrast agent for magnetic resonance (MR) ventilation imaging of the lungs. METHODS:Gadolinium-DTPA (gadopentetate dimeglumine, Schering AG, Berlin, Germany, 100 mmol Gd/L) was modifie...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199712000-00010
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to test the feasibility of an investigational dual-channel next-generation endorectal coil (NG-ERC) in vivo, to quantitatively assess signal-to-noise ratio (SNR), and to get an impression of image quality compared with the current clinically available single-loop endorectal ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182a56678
更新日期:2014-01-01 00:00:00
abstract::Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D2O, and in tumor adenosine triphosphate (ATP), measured by 31P ma...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198912000-00022
更新日期:1989-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To analyze changes in Doppler ultrasound variables of the portal vein in relation to liver biopsy findings, the authors performed a prospective study of 316 Doppler ultrasound examinations in the first 2 weeks after orthotopic liver transplantation on 23 patients. METHODS:Recordings were obtai...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199612000-00007
更新日期:1996-12-01 00:00:00
abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198712000-00008
更新日期:1987-12-01 00:00:00
abstract:PURPOSE:The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized and clinically relevant laboratory conditions. METHODS:The T1 relaxivity, r1, was determined in human plasma at 1.5, 3, and 7 T, and in human blood at 3 T at 37°C in phantoms ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000577
更新日期:2019-09-01 00:00:00
abstract::Receiver operating characteristic (ROC) analysis has been used in a broad variety of medical imaging studies during the past 15 years, and its advantages over more traditional measures of diagnostic performance are now clearly established. But despite the essential simplicity of the approach, workers in the field ofte...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198903000-00012
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:The aim of this work was to quantitatively evaluate the pharmacokinetic pattern of Gd-EOB-DTPA in a model of isolated and perfused mouse liver by using magnetic resonance imaging (MRI) and monochromatic quantitative computed tomography (MQCT). MATERIALS AND METHODS:For MQCT, perfusions were realized with th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000174474.43772.58
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Comparison of intravenous Fenestra VC-enhanced computed tomography (CT) with gadopentetate dimeglumine and Ferucarbotran contrast-enhanced magnetic resonance imaging (MRI) for the in vivo imaging of hepatic ischemia/reperfusion injury (IRI) in a murine model. MATERIAL AND METHODS:After induction of hepatic ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318155aa2e
更新日期:2008-02-01 00:00:00
abstract::Magnetic resonance angiography (MRA) for application in the musculoskeletal system is progressing at a rapid pace. The clinical role of this new technique is still being developed, although a number of uses have already become well recognized, and MRA is diffusing into clinical practice. This article describes the bas...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199212002-00014
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVES:Transcatheter arterial embolization (TAE) is used for the treatment of patients with malignant liver tumors. However, the proangiogenesis effect of TAE-associated hypoxia has not been adequately studied. The goal of this study was to determine angiogenic activity in tumors subjected to TAE by evaluating the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000209663.00629.8a
更新日期:2006-06-01 00:00:00
abstract::The effects of edge gradient and blur on the detection pulmonary nodules were studied, using a test series of 175 artificial nodules on 30 chest films. The nodules were of homogeneous texture, about 1 cm in diameter and had a mean contrast of .12. Six observers viewed the film set, scoring both location and confidence...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197901000-00004
更新日期:1979-01-01 00:00:00
abstract::The Point Spread Function (PSF) in NMR imaging is the result of both the line broadening due to magnet field inhomogeneity and the intrinsic spectrum of the nucleus at resonance. In the case of proton imaging, the line broadening dominates the small chemical shifts and the spectral lines are not resolved. This is not ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198503000-00016
更新日期:1985-03-01 00:00:00
abstract::An ultrasound phantom was constructed simulating fetal femurs in amniotic fluid. Bones of 26, 36, 50, 58, and 70 mm, representative of gestational ages ranging from 17 to 36 weeks, were scanned with mechanical sector, phased sector, and linear array systems (ATL, Diasonics, Acuson, and GE). Measurements were made with...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198505000-00016
更新日期:1985-05-01 00:00:00
abstract:OBJECTIVE:To compare image quality and geometric distortion between readout-segmented diffusion-weighted imaging (rs-DWI) and selective-excitation accelerated reduced-field of view (FOV) DWI (sTX-DWI) of the prostate. MATERIALS AND METHODS:Sixty-five patients underwent 3-T MRI of the prostate including rs-DWI and sTX-...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000184
更新日期:2015-11-01 00:00:00
abstract::A method is presented by whichcomputed tomography scans carried out at a number of energies may be utilized to obtain cross-sectional images of density and atomic number in addition to the conventional array of linear attenuation coefficients. This type of analysis has been carried out for various substances of biolog...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197703000-00016
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVES:To test the technique and feasibility of translating tumor suspicious region maps in the prostate, obtained by multimodality, anatomic, and functional 3T magnetic resonance imaging (MRI) data to 32-channel coil, T2-weighted (T2-w), 3T MR images, for directing MR-guided biopsies. Furthermore, to evaluate the ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31817d0506
更新日期:2008-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To develop a computer-assisted analysis of complex joint motion based on standard fluoroscopic sequences. MATERIALS AND METHODS:Fluoroscopic sequences of 10 normal shoulders and 20 patients after total shoulder arthroplasty were recorded during abduction and adduction. The analysis of the shou...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200202000-00004
更新日期:2002-02-01 00:00:00
abstract::Altered concentrations of brain beta endorphin and spinal cord encephalin have been reported in mice with iatrogenic arachnoiditis. We measured beta-endorphin concentration in cerebrospinal fluid (CSF) in normal monkeys and in monkeys with various degrees of arachnoiditis resulting from myelography and spinal surgery ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198803000-00006
更新日期:1988-03-01 00:00:00
abstract::The interdisciplinary approach to medical education has often been deficient in medical school curricula. Because of the nonintegrated approach to medical education, problem solving capabilities are not fostered. The clinical presentation of a patient, the imaging modalities used to investigate the patient, and the ul...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198604000-00015
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVES:To determine the impact of slice thickness on semiautomatic lymph node analysis. MATERIALS AND METHODS:Thoracic multislice computed tomography (MSCT) of 46 patients with NSCLC were reconstructed at 1.0-, 3.0-, and 5.0-mm slice thickness. Two radiologists independently determined long and short axis diameter...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181c443e1
更新日期:2010-02-01 00:00:00
abstract::We evaluated the density distribution (anterior-posterior) of the right lung in 19 acutely anesthetized supine dogs using computed transmission tomography (CTT). Eleven dogs served as controls, and eight received 0.12 cc/kg of intravenously administered oleic acid. The latter were sequentially imaged over 1 hour. Nine...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::The authors conducted an observer performance study to compare breast lesion detection of conventional mammography (CM) with teleradiology (TE) transmitted mammograms. One hundred four abnormal, single-projection mammographic images were transmitted by teleradiology. Abnormalities included 11 cases with skin thickenin...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199010000-00007
更新日期:1990-10-01 00:00:00
abstract::Because of relatively low acute toxicity, iosulamide meglumine has been recommended as an improved contrast material for intravenous cholangiography. It has been postulated that high doses of the compound could be given safely with the expectation of achieving greater biliary excretion and improved opacification of th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198105000-00016
更新日期:1981-05-01 00:00:00
abstract::The biliary and urinary excretion of sodium tyropanoate (Bilopaque) and sodium ipodate (Oragrafin) were studied in unanesthetized bile-fistula dogs using stepwise, increasing, intravenous infusions of the contrast materials. A constant intravenous infusion of sodium taurocholate was administered at the rate of either ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197701000-00017
更新日期:1977-01-01 00:00:00
abstract::Twenty-six patients who had received 43 grafts were studied before and after coronary artery vein bypass surgery. Cine ventriculograms taken in the right anterior oblique projection were analyzed and regional ejection fractions calculated. Single and multiple grafts were considered separately as were thrombosed and pa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197705000-00001
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess whether the recently developed method of grating-based x-ray dark-field radiography can improve the diagnosis of pulmonary emphysema in vivo. MATERIALS AND METHODS:Pulmonary emphysema was induced in female C57BL/6N mice using endotracheal instillation of porcine pancr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000067
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the ability of a flow-sensitive alternating inversion recovery-arterial spin labeling (FAIR-ASL) technique to track renal perfusion changes during pharmacologic and physiologic alterations in renal blood flow using microspheres as a gold standard. MATERIALS AND METHODS...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181f5e101
更新日期:2011-02-01 00:00:00