Abstract:
OBJECTIVES:The objective of this study was to evaluate the correlation between dynamic gadoxetic acid-enhanced magnetic resonance imaging parameters and specific uptake values (SUVs) derived from ¹⁸fluorodeoxyglucose (¹⁸F-FDG) and ⁶⁸Ga-DOTA-Tyr(3)-octreotate (⁶⁸Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT) in patients with liver metastases of neuroendocrine neoplasms. METHODS:A total of 42 patients with hepatic metastases of neuroendocrine neoplasms were prospectively enrolled and underwent both dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and PET/CT, using either ¹⁸F-FDG or ⁶⁸Ga-DOTATATE as tracer. The DCE-MRI was performed at 3 T with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid acquiring 48 slices every 2.2 seconds for 5 minutes. Three regions of interest (ROIs) representing the liver background and up to 3 ROIs representing metastatic liver tissue were coregistered in the PET/CT and in the DCE-MRI data sets. For each patient, a dedicated dual-inlet, 2-compartment uptake model was fitted to the enhancement curves of DCE-MRI ROIs and perfusion parameters were calculated. Lesion-to-background ratios of SUVs were correlated with corresponding lesion-to-background ratios of the perfusion parameters arterial plasma flow, venous plasma flow, total plasma flow, extracellular mean transit time, extracellular volume, arterial flow fraction, intracellular uptake rate, and hepatic uptake fraction using the Spearman coefficient. RESULTS:Whereas the lesion-to-background ratios of arterial plasma flow and arterial flow fraction of liver metastases correlated negatively with the lesion-to-background ratios of SUV(mean) derived from ⁶⁸Ga-DOTATATE PET/CT (r = -0.54, P < 0.001; r = -0.39, P < 0.001, respectively), they correlated positively with the lesion-to-background ratios of SUV(mean) derived from ¹⁸F-FDG-PET/CT (r = 0.51, P < 0.05; r = 0.68, P < 0.01, respectively). The lesion-to-background ratios of the DCE-MRI parameters extracellular mean transit time and extracellular volume correlated very weakly with the lesion-to-background ratios of SUV(mean) from ⁶⁸Ga-DOTATATE PET/CT, whereas venous plasma flow, total plasma flow, hepatic uptake fraction, and intracellular uptake rate showed no correlation between DCE-MRI and PET/CT. CONCLUSIONS:Both ⁶⁸Ga-DOTATATE and ¹⁸fluorodeoxyglucose PET/CT partially correlate with MRI perfusion parameters from the dual-inlet, 2-compartment uptake model. The results indicate that the paired imaging methods deliver complementary functional information.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Armbruster M,Sourbron S,Haug A,Zech CJ,Ingrisch M,Auernhammer CJ,Nikolaou K,Paprottka PM,Rist C,Reiser MF,Sommer WHdoi
10.1097/RLI.0b013e3182a4eb4asubject
Has Abstractpub_date
2014-01-01 00:00:00pages
7-14issue
1eissn
0020-9996issn
1536-0210journal_volume
49pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:The vasoconstriction of the renal arteries is frequently considered as a crucial factor for radiocontrast-induced nephropathy. A direct effect of iodinated radiographic contrast medium (RCM) on vascular smooth muscle is supposed to be one component of the vascular response. We studied the effec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200208000-00005
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the feasibility of a computed tomography (CT) protocol enabling the visualization of the prostatic artery (PA) before prostatic artery embolization (PAE) in benign prostatic hyperplasia, which provides quantitative perfusion information of the prostate gland. MATERIALS ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000582
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS:A large, single-center retrospective population sur...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000431
更新日期:2018-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A computerized system that applies the case-based approach to training radiologists to diagnose brain tumors was designed. The authors attempted to provide residents a tool that supports their visual memory and inducts case-based reasoning. METHODS:A relational database with a digital image li...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199404000-00020
更新日期:1994-04-01 00:00:00
abstract::Comparatively new in the roentgen evaluation of infants and children, xerography would appear to be ideal for portraying the pediatric airway. Since the radiation dose of xerography is higher than conventional radiography, its image quality is the subject of careful scrutiny in a pediatric setting here described in 23...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197807000-00002
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard clinical doses of 2 Gd-based contrast agents: ProHance and Omniscan. MATERIALS AND METHODS:After administration of 0.1 mmol/kg of Gd chelate to patients undergoing hi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000186569.32408.95
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:We sought to develop a robotic system for computed tomography (CT)-guided biopsy to validate the feasibility, accuracy, and efficacy of the system using phantom tests. MATERIALS AND METHODS:Ten peas (mean diameter 9.9+/-0.4 mm) embedded within a gel phantom were selected for biopsy. Once the best access was de...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000155285.05672.cf
更新日期:2005-04-01 00:00:00
abstract::The authors reexamined a suspected difference in the effects of clinical information upon detection of nodules vs. more diverse lesions by directly incorporating classification specificity into detection ROC analysis. Categorical prompts, correct for specific abnormalities, led to detection superior to unprompted read...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198801000-00011
更新日期:1988-01-01 00:00:00
abstract::Virtually all receiver operating characteristic (ROC) studies of medical imaging methods have involved data collected on a discrete confidence-rating scale, though in principle ROC studies can be conducted with either discrete or continuous scales. Continuous scales provide potential advantages in medical applications...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199202000-00016
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVES:Altered systolic blood flow in the ascending aorta has been correlated with increased aortic growth in patients with bicuspid aortic valves (BAVs). We used conventional, 2-dimensional (2D) phase contrast magnetic resonance imaging (PC-MRI) to assess the relationship between altered flow and future growth in ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000064
更新日期:2014-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:It is widely believed that down-sizing catheters, and possibly needles, will decrease damage to the entry vessel in the performance of angiography. The purposes of this in vitro experiment are to determine if smaller needles produce less arterial wall damage than larger needles and to assess th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199210000-00001
更新日期:1992-10-01 00:00:00
abstract::A patient, suffering a severe anaphylactoid reaction to contrast material injected for an intravenous pyelogram, developed a consumption coagulopathy and evidence of complement activation. Precontrast complement values suggested that the patient had been processing complement via the classical pathway, perhaps as a co...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00004
更新日期:1980-11-01 00:00:00
abstract::A photographic unsharp masking technique for improving the latitude of chest radiographs without sacrificing image contrast or detail is described. An unsharp mask film, prepared from a scout film of the patient's chest, is placed between the film and the front (entrance) screen in the cassette. A second radiograph th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198107000-00007
更新日期:1981-07-01 00:00:00
abstract::The retropsoas recess, a previously undescribed normal anatomic variant, is reported. In most individuals, the space posterior to the belly of the psoas muscle contains fat within the posterior pararenal space. However, a retrospective review of 250 consecutive CT examinations of the abdomen revealed 11 cases (4.4%) i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198707000-00004
更新日期:1987-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:As part of a general examination of the effect of blood flow patterns on the growth and risk of rupture of abdominal aortic aneurysms, the authors investigated the flow through an experimental model of a fusiform aneurysm. MATERIALS AND METHODS:Aneurysms were simulated in polyvinyl chloride tu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199207000-00008
更新日期:1992-07-01 00:00:00
abstract::The problem of inhomogeneous mixing encountered during hepatic artery (HA) chemotherapy infusion was assessed and a practical solution examined. A glass model of the human HA distribution was used to determine mixing homogeneity of low flow (1.4 mL/minute) dye infusion into pulsatile flow (280-300 mL/minute) of a flui...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198807000-00007
更新日期:1988-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the short-term effects of a new nitinol stent on canine arteries. METHODS:Eighteen nitinol mesh stents were placed in abdominal aortas, common iliac arteries, and renal arteries of six dogs. Angiography was performed to evaluate the patency rates and structural changes of arteries ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199905000-00007
更新日期:1999-05-01 00:00:00
abstract::Early detection of pancreatic ductal adenocarcinoma (PDAC) represents the most significant step toward the treatment of this aggressive lethal disease. Previously, we engineered a preclinical Thy1-targeted microbubble (MBThy1) contrast agent that specifically recognizes Thy1 antigen overexpressed in the vasculature of...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000697
更新日期:2020-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:High signal intensity in the basal ganglia on T1-weighted MR imaging has been reported in chronic manganese (Mn) poisoning. However, the exact meaning of the high signal intensity remains unclear: does it result from Mn itself, secondary pathologic changes of the brain tissue, or both? The goal...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199906000-00001
更新日期:1999-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors differentiate breast lesions on sonography by measurements in two compression states that are perpendicular to each other. METHODS:Diameters of 100 breast lesions were measured preoperatively under lateromedial and craniocaudal compression with a new sonographic method. This method...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199607000-00003
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVES:Multidetector-row computed tomography coronary images are usually analyzed in mid-diastole (MD). Because of slow coronary motion also in end-systole (ES), we evaluated the impact on image quality of including ES images and defined an efficient reconstruction protocol. MATERIAL AND METHODS:In 50 coronary mul...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000153930.34439.e4
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the image quality and diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) at 3.0 T compared with that at 1.5 T used for patients. MATERIALS AND METHODS:This study was approved by our institutional review board, and informed consent was obtained from all patien...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181b4c0ae
更新日期:2009-09-01 00:00:00
abstract::A nonionic contrast medium (iohexol) was evaluated for safety and efficacy in pediatric angiocardiography in this study of 15 patients, age 6 to 82 months. Patients carried a preliminary diagnosis of congenital heart disease. Subjects were injected with iohexol, 350 mg iodine/ml of solution with an average volume of 2...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Using real-time ultrasound, the motions of the tongue, hyoid bone, and larynx were monitored and timed during swallowing in ten normal subjects. A well-defined propulsive wave of the tongue was observed during swallowing a 5-cc water bolus. The body of the hyoid bone was identified on the ultrasound scan as a high ech...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198403000-00003
更新日期:1984-03-01 00:00:00
abstract::Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to determine whether targeting microbubbles to clots would enhance ultrasound imaging. Systematic studies were designed to determine whether in vitro methodology is an acceptable predictor of in...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200211000-00001
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess whether fluorochrome-coupled bacterial magnetic nanoparticles can be used as bimodal contrast agent for both magnetic resonance imaging (MRI) and near-infrared fluorescence optical (NIRF) imaging of cultured macrophages. MATERIALS AND METHODS:Bacterial magnetic nanopa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000255832.44443.e7
更新日期:2007-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To establish a pig model suitable for imitating pulmonary emboli to facilitate research in the diagnosis of pulmonary embolism. METHODS:Thirteen animals were anesthetized, mechanically ventilated, and subjected to pulmonary artery catheterization initiated from the right external jugular vein....
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200005000-00003
更新日期:2000-05-01 00:00:00
abstract::Polylysine covalently linked to moieties of gadopentetate (Gd-DTPA), for use as a macromolecular blood pool marker for contrast material-enhanced magnetic resonance imaging (MRI), was characterized by means of physicochemical measurements and pharmacokinetics in rats and rabbits and compared with Gd-DTPA. Gd-DTPA-poly...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199111000-00008
更新日期:1991-11-01 00:00:00
abstract::Capacity-limited elimination of sodium iopanoate and a reproducible apparent transport maximum (Tm) were demonstrated in nonoperated dogs having an intact enterohepatic circulation and normal endogenous bile salt pool. Using a multiple infusion technique, estimation of apparent Tm of iopanoate in the liver was possibl...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197601000-00007
更新日期:1976-01-01 00:00:00