Interference of gadolinium-containing contrast-enhancing agents with colorimetric calcium laboratory testing.

Abstract:

OBJECTIVES:The purpose of this study was to evaluate the extent to which various commercially available gadolinium-containing contrast-enhancing (CE) agents can interfere with the measurement of calcium levels by currently used laboratory methods, suggesting (spurious) hypocalcemia or hypercalcemia with a potential risk for the patient. MATERIALS AND METHODS:Serum and plasma from healthy volunteers were spiked with various concentrations of 4 marketed CE agents. The calcium concentration was measured by widely used laboratory methods: the colorimetric systems Cobas Mira and Vitros 950 analyzer. RESULTS:The measurement of calcium in serum and in plasma was not affected by the presence of gadopentetate dimeglumine (Magnevist, Schering AG, Berlin, Germany) or gadobenate dimeglumine (MultiHance, Bracco-Byk Gulden, Constance, Switzerland) in clinically relevant concentrations (up to 5 mM CE agent). Gadodiamide (Omniscan, Amersham Health, Cork, Ireland) and gadoversetamide (OptiMARK, Mallinckrodt, St. Louis, MO) did produce noticeable-and therefore potentially misleading-effects at these concentrations. CONCLUSIONS:The study demonstrates that gadopentetate dimeglumine and gadobenate dimeglumine generate no interference with colorimetric methods for calcium determination, whereas strong interference was shown for gadodiamide and gadoversetamide under clinically relevant conditions.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Löwe A,Balzer T,Hirt U

doi

10.1097/01.rli.0000170447.45577.5e

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

521-5

issue

8

eissn

0020-9996

issn

1536-0210

pii

00004424-200508000-00004

journal_volume

40

pub_type

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