Abstract:
RATIONALE AND OBJECTIVES:Tools for monitoring modern target-specific antiangiogenic and antivascular therapies are highly desirable because treatment strategies are time consuming, expensive, and yet sometimes ineffective. Therefore, the aim of this experimental study was to evaluate the predictive value of steady-state ultrasmall particles of iron oxide (USPIO; SH U 555 C)-enhanced magnetic resonance imaging (MRI) for early assessment of antivascular tumor-treatment effectiveness. METHODS:Mice were inoculated with an HT-1080 fibrosarcoma xenograft and subjected to target-specific antivascular therapy using a selective thrombogenic vascular-targeting agent (truncated tissue factor fused to RGD peptide) or saline as control. Four to 8 hours after treatment, the USPIO-induced change in the transverse relaxation rate DeltaR2* was measured by MRI, and the vascular volume fraction (VVF) was calculated by calibrating DeltaR2* of the tumor by DeltaR2* of muscle tissue. Treatment response was defined by histologic grading of vascular thrombosis and tumor necrosis. RESULTS:After thrombogenic treatment, half of the HT-1080 xenograft-bearing animals showed only minor (=nonresponder) whereas the other half showed extensive tumor thrombosis (=responders). For responders, a significant decrease of DeltaR2* and VVF was observed compared with the control group (DeltaR2*: controls: 16 +/- 1 s-1 vs. responder: 4 +/- 2 s-1; P < 0.001) whereas DeltaR2* and VVF remained nearly unchanged for nonresponders (DeltaR2*: nonresponder 14 +/- 2 s-1). VVF and DeltaR2* values correlated inversely with the histologic grading of vascular thrombosis and tumor necrosis (VVF: r = -0.8; DeltaR2*: r = -0.71; P < 0.01). CONCLUSION:USPIO-enhanced MRI allows a noninvasive, early assessment of treatment efficacy of thrombogenic vascular-targeting agents.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Persigehl T,Matuszewski L,Kessler T,Wall A,Meier N,Ebert W,Berdel WE,Heindel W,Mesters R,Bremer Cdoi
10.1097/RLI.0b013e3180d5cbd9subject
Has Abstractpub_date
2007-12-01 00:00:00pages
791-6issue
12eissn
0020-9996issn
1536-0210pii
00004424-200712000-00001journal_volume
42pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:The vascular opacification characteristics of a new nonionic, dimeric contrast agent, iodixanol, have been compared with a nonionic, monomeric agent, iohexol, using ultrafast computed tomography (UFCT). METHODS:In 10 experiments with mongrel dogs, the contrast agents were alternately injected ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199212000-00011
更新日期:1992-12-01 00:00:00
abstract:PURPOSE:To evaluate the technical feasibility of high spatial resolution contrast-enhanced magnetic resonance angiography (CE-MRA) with highly accelerated parallel acquisition at 3.0 T using a 32-channel phased array coil, and a high relaxivity contrast agent. MATERIALS AND METHODS:Ten adult healthy volunteers (5 men,...
journal_title:Investigative radiology
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To test noninvasive inductive heating of implanted vascular stents as an alternative approach for reduction or prevention of neointimal hyperplasia. METHODS:Calorimetric pretests were performed to get an orientation on the different parameters of influence for inductive heating of stents. The ...
journal_title:Investigative radiology
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doi:10.1097/01.rli.0000117881.42422.72
更新日期:2004-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study sought to evaluate prospectively the diagnostic potential of unenhanced and enhanced color Doppler and power Doppler for the differentiation of tumors and tumorlike lesions of the breast. METHODS:Ninety-two patients with 110 tumors or tumorlike lesions of the breast were investigate...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199902000-00003
更新日期:1999-02-01 00:00:00
abstract::The purpose of this study was to establish the proton NMR relaxation times of collapsed but otherwise normal lung tissue and to determine whether an inflammatory process within a collapsed lung can be detected by alterations in relaxation times. The lungs of three groups of rabbits were studied: group A (n = 7) had a ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198508000-00004
更新日期:1985-08-01 00:00:00
abstract::A nonionic contrast medium (iohexol) was evaluated for safety and efficacy in pediatric angiocardiography in this study of 15 patients, age 6 to 82 months. Patients carried a preliminary diagnosis of congenital heart disease. Subjects were injected with iohexol, 350 mg iodine/ml of solution with an average volume of 2...
journal_title:Investigative radiology
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doi:
更新日期:1985-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors conduct technical feasibility and performance studies on a new 0.009-inch nitinol microguidewire for potential neuroendovascular applications. METHODS:In vivo microcatheterizations of brachiocephalic arteries were performed in four pigs using the 0.009-inch nitinol microguidewire w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199704000-00008
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tom...
journal_title:Investigative radiology
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199105000-00009
更新日期:1991-05-01 00:00:00
abstract::A new technique for the noninvasive measurement of an index of renal blood flow is described. The method utilizes ultrasound determined renal volume and radionuclide assessment of the mean transit time of a pertechnetate bolus through the kidneys. From this information a value for flow is calculated according to compa...
journal_title:Investigative radiology
pub_type: 杂志文章
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abstract:OBJECTIVE:The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS:Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000383
更新日期:2017-09-01 00:00:00
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journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1988-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199410000-00005
更新日期:1994-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The ventral sacroiliac ligament (VSL), which bridges the sacroiliac (SI) joint anteriorly, has been described as an important stabilizing structure of the joint, but no data exist regarding its assessment with routine and advanced imaging methods. The authors determine the imaging appearance of...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199608000-00009
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To assess prospectively, in healthy subjects and in patients with dilated cardiomyopathy (DCM) and hypertrophic obstructive cardiomyopathy (HOCM), the 3-dimensional (3D) shape, size, and motion of the mitral annulus (MA) using computed tomography (CT). MATERIALS AND METHODS:Twenty patients with no cardiac ab...
journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e3181994a73
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:We aimed to assess whether migraine is associated with changes in the distribution of the venous drainage through primary and secondary pathways by using phase-contrast magnetic resonance imaging (MRI). METHODS:We examined 26 patients (37.3 ± 13.9 years) with recurring migraine headaches and 26 age- and gend...
journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e318210ecf5
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To investigate three-echo T2*-corrected Dixon magnetic resonance imaging (MRI) for noninvasively estimating hepatic fat content (HFC) compared with biopsy. MATERIALS AND METHODS:One hundred patients (50 men, 50 women; mean age, 57.7±14.2 years) underwent clinically indicated liver core biopsy (102 valid tiss...
journal_title:Investigative radiology
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doi:10.1097/RLI.0b013e31822b124c
更新日期:2011-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Gd-DTPA is a well-characterized, safe contrast agent frequently used in magnetic resonance imaging (MRI) of the central nervous system. The purpose of this double-blind, comparative MRI study of brain, spine, trunk, and limbs was to evaluate the safety and efficacy of Gd-DOTA versus Gd-DTPA in ...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199502000-00002
更新日期:1995-02-01 00:00:00
abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197805000-00011
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journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199808000-00001
更新日期:1998-08-01 00:00:00
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journal_title:Investigative radiology
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更新日期:2020-07-01 00:00:00
abstract::A patient, suffering a severe anaphylactoid reaction to contrast material injected for an intravenous pyelogram, developed a consumption coagulopathy and evidence of complement activation. Precontrast complement values suggested that the patient had been processing complement via the classical pathway, perhaps as a co...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198011001-00004
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVES:Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a very low 5-year survival rate of 8%. The aims of this study are to determine reference values and physiologic confounders in healthy pancreas and to assess the diagnostic accuracy of ultrasound time-harmonic elastography (THE) in the d...
journal_title:Investigative radiology
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doi:10.1097/RLI.0000000000000638
更新日期:2020-05-01 00:00:00
abstract::French physicians must obtain their patient's consent before carrying out an action that interferes with the patient's corporal integrity. The doctor must use simple, approximate, intelligent, and honest words that help the patient to reach the indispensable decision. Proof of lack of consent lies with the patient. Th...
journal_title:Investigative radiology
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doi:10.1097/00004424-198809001-00006
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVES:We sought to assess large bowel motility, induced by 2 prokinetic agents, senna tea and erythromycin, using functional cine magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twelve volunteers underwent functional cine MRI before and after the administration of senna tea or erythromycin. The protocol c...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000183054.43131.a8
更新日期:2005-11-01 00:00:00
abstract::Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors' sera responded to lower concentrations of cont...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198307000-00018
更新日期:1983-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model. MATERIALS AND METHODS:Fourteen cats were prepared for acute myocardial infarction with 90-minute...
journal_title:Investigative radiology
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doi:
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:: The final event leading to myocardial infarction is adhesion and activation of platelets after rupture of an atherosclerotic plaque, ending in thrombotic occlusion of the coronary artery. Imaging of imminent vessel occlusion may improve patient care. The feasibility of molecular magnetic resonance imaging (...
journal_title:Investigative radiology
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更新日期:2011-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Emulsions of perfluorocarbons (PFCs) have been tested as blood substitutes. However, evidence exists that there is long-term retention of some PFCs by the organs of the reticuloendothelial system (RES). The authors investigate organ retention of the blood substitute component, perfluorotripropy...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199208000-00012
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVES:We compared the image quality and diagnostic performance of 2 fat-suppression methods for black-blood T2-weighted fast spin-echo (FSE), which are as follows: (a) short T1 inversion recovery (STIR; FSE-STIR) and (b) spectral adiabatic inversion recovery (SPAIR; FSE-SPAIR), for detection of acute myocardial in...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182718672
更新日期:2013-01-01 00:00:00