The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes.

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...

journal_title：Neuron

authors： Dong Z,Chen W,Chen C,Wang H,Cui W,Tan Z,Robinson H,Gao N,Luo B,Zhang L,Zhao K,Xiong WC,Mei L

更新日期：2020-02-05 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:Although motion-sensitive neurons in macaque middle temporal (MT) area are conventionally characterized using stimuli whose velocity remains constant for 1-3 s, many ecologically relevant stimuli change on a shorter time scale (30-300 ms). We compared neuronal responses to conventional (constant-velocity) and time-var...

journal_title：Neuron

authors： Buracas GT,Zador AM,DeWeese MR,Albright TD

更新日期：1998-05-01 00:00:00

abstract：:Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presyna...

journal_title：Neuron

authors： Wyszynski M,Kim E,Dunah AW,Passafaro M,Valtschanoff JG,Serra-Pagès C,Streuli M,Weinberg RJ,Sheng M

更新日期：2002-03-28 00:00:00

abstract：:Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expre...

journal_title：Neuron

authors： Bramblett DE,Pennesi ME,Wu SM,Tsai MJ

更新日期：2004-09-16 00:00:00

abstract：:Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...

journal_title：Neuron

authors： Frank CA,Kennedy MJ,Goold CP,Marek KW,Davis GW

更新日期：2006-11-22 00:00:00

abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...

journal_title：Neuron

authors： Watabe-Uchida M,Zhu L,Ogawa SK,Vamanrao A,Uchida N

更新日期：2012-06-07 00:00:00

abstract：:Little is known about the molecular mechanisms underlying differences in the ligand binding properties of AMPA, kainate, and NMDA subtype glutamate receptors. Crystal structures of the GluR5 and GluR6 kainate receptor ligand binding cores in complexes with glutamate, 2S,4R-4-methylglutamate, kainate, and quisqualate h...

journal_title：Neuron

authors： Mayer ML

更新日期：2005-02-17 00:00:00

abstract：:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...

journal_title：Neuron

authors： Pitkow X

更新日期：2016-10-19 00:00:00

abstract：:Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapt...

journal_title：Neuron

authors： Jones RS,Carroll RC,Nawy S

更新日期：2012-08-09 00:00:00

abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...

journal_title：Neuron

authors： McGinley MJ,Vinck M,Reimer J,Batista-Brito R,Zagha E,Cadwell CR,Tolias AS,Cardin JA,McCormick DA

更新日期：2015-09-23 00:00:00

abstract：:While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...

journal_title：Neuron

authors： Frade JM,Barde YA

更新日期：1998-01-01 00:00:00

abstract：:Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final...

journal_title：Neuron

authors： Chang GQ,Hao Y,Wong F

更新日期：1993-10-01 00:00:00

abstract：:Neuroligins (NLs) are critical for synapse formation and function. NL3 R451C is an autism-associated mutation. NL3 R451C knockin (KI) mice exhibit autistic behavioral abnormalities, including social novelty deficits. However, neither the brain regions involved in social novelty nor the underlying mechanisms are clearl...

journal_title：Neuron

authors： Cao W,Lin S,Xia QQ,Du YL,Yang Q,Zhang MY,Lu YQ,Xu J,Duan SM,Xia J,Feng G,Xu J,Luo JH

更新日期：2018-03-21 00:00:00

abstract：:Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...

journal_title：Neuron

authors： Romo R,Hernández A,Zainos A,Brody CD,Lemus L

更新日期：2000-04-01 00:00:00

abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...

journal_title：Neuron

authors： Kay LM,Beshel J,Martin C

更新日期：2006-08-03 00:00:00

abstract：:In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...

journal_title：Neuron

authors： Esquivelzeta Rabell J,Haesler S

更新日期：2020-10-28 00:00:00

abstract：:Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...

journal_title：Neuron

authors： Dudman JT,Siegelbaum SA

更新日期：2006-03-02 00:00:00

abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...

journal_title：Neuron

authors： Hnasko TS,Edwards RH

更新日期：2006-09-07 00:00:00

abstract：:Neurons can maintain stable synaptic connections across adult life. However, the signals that regulate expression of synaptic proteins in the mature brain are incompletely understood. Here, we describe a transcriptional feedback loop between the biosynthesis and repertoire of specific phospholipids and the synaptic ve...

journal_title：Neuron

authors： Tsai JW,Kostyleva R,Chen PL,Rivas-Serna IM,Clandinin MT,Meinertzhagen IA,Clandinin TR

更新日期：2019-02-20 00:00:00

abstract：:We have studied the expression of NGF receptor (NGFR) mRNA in the mouse trigeminal system at closely staged intervals throughout development. The level of NGFR mRNA per neuron is at a constant low level before the earliest axons reach the target field and increases 5-fold to plateau shortly after the arrival of the la...

journal_title：Neuron

authors： Wyatt S,Shooter EM,Davies AM

更新日期：1990-03-01 00:00:00

abstract：:Predictive coding posits that neural systems make forward-looking predictions about incoming information. Neural signals contain information not about the currently perceived stimulus, but about the difference between the observed and the predicted stimulus. We propose to extend the predictive coding framework from hi...

journal_title：Neuron

authors： Koster-Hale J,Saxe R

更新日期：2013-09-04 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....

journal_title：Neuron

authors： van den Maagdenberg AM,Pietrobon D,Pizzorusso T,Kaja S,Broos LA,Cesetti T,van de Ven RC,Tottene A,van der Kaa J,Plomp JJ,Frants RR,Ferrari MD

更新日期：2004-03-04 00:00:00

abstract：:The establishment of spinal motor neuron subclass diversity is achieved through developmental programs that are aligned with the organization of muscle targets in the limb. The evolutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remains unclear how the specification of digit...

journal_title：Neuron

authors： Mendelsohn AI,Dasen JS,Jessell TM

更新日期：2017-02-22 00:00:00

abstract：:Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...

journal_title：Neuron

authors： Russo AF,Crenshaw EB 3rd,Lira SA,Simmons DM,Swanson LW,Rosenfeld MG

更新日期：1988-06-01 00:00:00

abstract：:Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...

journal_title：Neuron

authors： Stepanyants A,Tamás G,Chklovskii DB

更新日期：2004-07-22 00:00:00

abstract：:GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...

journal_title：Neuron

authors： Khoshkhoo S,Vogt D,Sohal VS

更新日期：2017-01-18 00:00:00

abstract：:Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial....

journal_title：Neuron

authors： Kaur D,Yantiri F,Rajagopalan S,Kumar J,Mo JQ,Boonplueang R,Viswanath V,Jacobs R,Yang L,Beal MF,DiMonte D,Volitaskis I,Ellerby L,Cherny RA,Bush AI,Andersen JK

更新日期：2003-03-27 00:00:00

abstract：VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...

journal_title：Neuron

authors： Harwell CC,Parker PR,Gee SM,Okada A,McConnell SK,Kreitzer AC,Kriegstein AR

更新日期：2012-03-22 00:00:00