A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression.

Abstract:

:Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels. We generated a knockin mouse model carrying the human pure FHM-1 R192Q mutation and found multiple gain-of-function effects. These include increased Ca(v)2.1 current density in cerebellar neurons, enhanced neurotransmission at the neuromuscular junction, and, in the intact animal, a reduced threshold and increased velocity of cortical spreading depression (CSD; the likely mechanism for the migraine aura). Our data show that the increased susceptibility for CSD and aura in migraine may be due to cortical hyperexcitability. The R192Q FHM-1 mouse is a promising animal model to study migraine mechanisms and treatments.

journal_name

Neuron

journal_title

Neuron

authors

van den Maagdenberg AM,Pietrobon D,Pizzorusso T,Kaja S,Broos LA,Cesetti T,van de Ven RC,Tottene A,van der Kaa J,Plomp JJ,Frants RR,Ferrari MD

doi

10.1016/s0896-6273(04)00085-6

subject

Has Abstract

pub_date

2004-03-04 00:00:00

pages

701-10

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896627304000856

journal_volume

41

pub_type

杂志文章

相关文献

NEURON文献大全
  • Natural scenes viewing alters the dynamics of functional connectivity in the human brain.

    abstract::Spontaneous fMRI fluctuations are organized in large-scale spatiotemporal structures, or resting-state networks (RSN). However, it is unknown how task performance affects RSN dynamics. We use MEG to measure slow (∼0.1 Hz) coherent fluctuations of band-limited power (BLP), a robust correlate of RSN, during rest and mov...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.06.022

    authors: Betti V,Della Penna S,de Pasquale F,Mantini D,Marzetti L,Romani GL,Corbetta M

    更新日期:2013-08-21 00:00:00

  • Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons.

    abstract::Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.03.021

    authors: Sharif B,Ase AR,Ribeiro-da-Silva A,Séguéla P

    更新日期:2020-06-17 00:00:00

  • Nociceptors--noxious stimulus detectors.

    abstract::In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2007.07.016

    authors: Woolf CJ,Ma Q

    更新日期:2007-08-02 00:00:00

  • Bad Ac-etylated Tau.

    abstract::By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2016.04.008

    authors: Hettinger JC,Cirrito JR

    更新日期:2016-04-20 00:00:00

  • Neural regulation of hematopoiesis, inflammation, and cancer.

    abstract::Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2015.01.026

    authors: Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

    更新日期:2015-04-22 00:00:00

  • Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation.

    abstract::The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.05.034

    authors: Zerbi V,Floriou-Servou A,Markicevic M,Vermeiren Y,Sturman O,Privitera M,von Ziegler L,Ferrari KD,Weber B,De Deyn PP,Wenderoth N,Bohacek J

    更新日期:2019-08-21 00:00:00

  • Structure and assembly mechanism for heteromeric kainate receptors.

    abstract::Native glutamate receptor ion channels are tetrameric assemblies containing two or more different subunits. NMDA receptors are obligate heteromers formed by coassembly of two or three divergent gene families. While some AMPA and kainate receptors can form functional homomeric ion channels, the KA1 and KA2 subunits are...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.05.038

    authors: Kumar J,Schuck P,Mayer ML

    更新日期:2011-07-28 00:00:00

  • Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding.

    abstract::Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.03.028

    authors: Vinck M,Batista-Brito R,Knoblich U,Cardin JA

    更新日期:2015-05-06 00:00:00

  • Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model.

    abstract::How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an "activity set point" in single ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.04.002

    authors: O'Leary T,Williams AH,Franci A,Marder E

    更新日期:2014-05-21 00:00:00

  • The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor.

    abstract::Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relatio...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.08.006

    authors: Turner-Evans DB,Jensen KT,Ali S,Paterson T,Sheridan A,Ray RP,Wolff T,Lauritzen JS,Rubin GM,Bock DD,Jayaraman V

    更新日期:2020-10-14 00:00:00

  • Time Warping Reveals Hidden Features of Neuronal Population Responses.

    abstract::Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.12.010

    authors: Okun M

    更新日期:2020-01-22 00:00:00

  • A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship.

    abstract::Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00542-7

    authors: Bray S,Amrein H

    更新日期:2003-09-11 00:00:00

  • Silencing Neurons: Tools, Applications, and Experimental Constraints.

    abstract::Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2017.06.050

    authors: Wiegert JS,Mahn M,Prigge M,Printz Y,Yizhar O

    更新日期:2017-08-02 00:00:00

  • Learning without performance in PKC-deficient Drosophila.

    abstract::The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80270-6

    authors: Kane NS,Robichon A,Dickinson JA,Greenspan RJ

    更新日期:1997-02-01 00:00:00

  • Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina.

    abstract::We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(90)90058-n

    authors: Watanabe T,Raff MC

    更新日期:1990-03-01 00:00:00

  • CA3 mossy fiber connections: giant synapses that gain control.

    abstract::Neurons compensate their synaptic strengths to global changes in network activity. In this issue of Neuron, Lee et al. (2013) provide evidence in mature hippocampal networks that this homeostatic plasticity is achieved uniquely at the mossy fiber synapses on CA3 neurons. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2012.12.024

    authors: Chater TE,Goda Y

    更新日期:2013-01-09 00:00:00

  • Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans.

    abstract::Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.10.030

    authors: Ghosh DD,Sanders T,Hong S,McCurdy LY,Chase DL,Cohen N,Koelle MR,Nitabach MN

    更新日期:2016-12-07 00:00:00

  • Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?

    abstract::The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s0896-6273(02)00910-8

    authors: Xiong ZQ,McNamara JO

    更新日期:2002-09-12 00:00:00

  • Visual stimulation switches the polarity of excitatory input to starburst amacrine cells.

    abstract::Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.07.037

    authors: Vlasits AL,Bos R,Morrie RD,Fortuny C,Flannery JG,Feller MB,Rivlin-Etzion M

    更新日期:2014-09-03 00:00:00

  • The neurotransmitter cycle and quantal size.

    abstract::Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2007.09.001

    authors: Edwards RH

    更新日期:2007-09-20 00:00:00

  • Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli.

    abstract::Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.03.025

    authors: Lammel S,Ion DI,Roeper J,Malenka RC

    更新日期:2011-06-09 00:00:00

  • Blockade of ion channel expression in Xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs.

    abstract::Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90153-5

    authors: Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

    更新日期:1988-12-01 00:00:00

  • Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

    abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.04.009

    authors: Nelson AB,Gittis AH,du Lac S

    更新日期:2005-05-19 00:00:00

  • Swelling Gliotransmission by SWELL1 Channels.

    abstract::Astrocytes release glutamate, which can modulate nearby synapses, but how this release is accomplished remains debated. In this issue of Neuron, Yang et al. (2019) show that the volume-regulated anion channel Swell1 in astrocytes mediates the release of glutamate and impacts synaptic transmission, learning and memory,...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.05.005

    authors: Kofuji P,Araque A

    更新日期:2019-05-22 00:00:00

  • Multiple Running Speed Signals in Medial Entorhinal Cortex.

    abstract::Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.06.027

    authors: Hinman JR,Brandon MP,Climer JR,Chapman GW,Hasselmo ME

    更新日期:2016-08-03 00:00:00

  • Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses.

    abstract::In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)81065-x

    authors: Chen WR,Xiong W,Shepherd GM

    更新日期:2000-03-01 00:00:00

  • The dynamic synapse.

    abstract::The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2013.10.013

    authors: Choquet D,Triller A

    更新日期:2013-10-30 00:00:00

  • Getting formal with dopamine and reward.

    abstract::Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing a...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(02)00967-4

    authors: Schultz W

    更新日期:2002-10-10 00:00:00

  • The Geometry of Visual Cortical Maps.

    abstract::The primary visual cortex has a map of multiple visual parameters whose topographic relations remain poorly understood. A new study (Nauhaus et al., 2016) reveals a nearly geometric map-topography that coexists within a remarkably precise representation of visual space. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.08.001

    authors: Alonso JM

    更新日期:2016-08-17 00:00:00

  • Sex Differences in Susceptibility to Depression: A Role for LncRNAs.

    abstract::In this issue of Neuron, Issler et al. (2020) have identified the neuronal, long intergenic noncoding RNA LINC00473 as a potential molecular risk factor for the increased susceptibility for depression in females. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2020.05.016

    authors: Gururajan A

    更新日期:2020-06-17 00:00:00