Abstract:
:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural data.
journal_name
Neuronjournal_title
Neuronauthors
Pitkow Xdoi
10.1016/j.neuron.2016.10.007subject
Has Abstractpub_date
2016-10-19 00:00:00pages
275-277issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30708-5journal_volume
92pub_type
杂志文章相关文献
NEURON文献大全abstract::M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90272-s
更新日期:1993-07-01 00:00:00
abstract::Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00874-2
更新日期:2004-01-22 00:00:00
abstract::A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.08.039
更新日期:2004-09-16 00:00:00
abstract::In this issue of Neuron, Oh and Gu (2013) present a model in which intimately related embryonic nerves and blood vessels are patterned independently in response to different guidance cues from a central organizer: the whisker. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.09.040
更新日期:2013-10-16 00:00:00
abstract::Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the apparent diffusion coefficient (D(app)) of Ca2+, whereas mobile buffers contribute to Ca2+ redistribution. To estimate the impact of the expression of specific Ca2+-b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81247-7
更新日期:1997-03-01 00:00:00
abstract::Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.02.015
更新日期:2009-03-12 00:00:00
abstract::The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.01.032
更新日期:2006-03-02 00:00:00
abstract::Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00246-x
更新日期:2001-03-01 00:00:00
abstract::We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90113-x
更新日期:1989-07-01 00:00:00
abstract::In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.11.014
更新日期:2015-12-02 00:00:00
abstract::All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mou...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.08.005
更新日期:2019-11-06 00:00:00
abstract::Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.029
更新日期:2006-11-22 00:00:00
abstract::The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.05.008
更新日期:2012-06-07 00:00:00
abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.035
更新日期:2019-04-03 00:00:00
abstract::Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00141-2
更新日期:2004-03-25 00:00:00
abstract::Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimula...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.09.032
更新日期:2012-12-06 00:00:00
abstract::Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.06.012
更新日期:2019-09-04 00:00:00
abstract::KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.08.017
更新日期:2011-09-22 00:00:00
abstract::Cued spatial attention differentially modulates alpha power in attended relative to non-attended brain representations, termed the alpha asymmetry. Yet a causal role for alpha in attention is debated. In this issue of Neuron, Bagherzadeh et al., (2019) utilize neurofeedback to train alpha asymmetry and causally impact...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.12.033
更新日期:2020-02-05 00:00:00
abstract::Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.04.014
更新日期:2019-07-03 00:00:00
abstract::Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2008.08.020
更新日期:2008-09-25 00:00:00
abstract::The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.02.028
更新日期:2005-04-07 00:00:00
abstract::Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.09.034
更新日期:2016-10-05 00:00:00
abstract::Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.10.022
更新日期:2005-11-03 00:00:00
abstract::Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.12.032
更新日期:2009-02-12 00:00:00
abstract::The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2008.07.012
更新日期:2008-08-28 00:00:00
abstract::Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90132-8
更新日期:1988-11-01 00:00:00
abstract::Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.023
更新日期:2008-06-12 00:00:00
abstract::In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacological blocker 4-aminopyri...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90273-9
更新日期:1994-02-01 00:00:00
abstract::Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.02.026
更新日期:2013-04-24 00:00:00