Probability by Time.

Abstract:

:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural data.

journal_name

Neuron

journal_title

Neuron

authors

Pitkow X

doi

10.1016/j.neuron.2016.10.007

subject

Has Abstract

pub_date

2016-10-19 00:00:00

pages

275-277

issue

2

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(16)30708-5

journal_volume

92

pub_type

杂志文章

相关文献

NEURON文献大全
  • Selective reduction of one mode of M-channel gating by muscarine in sympathetic neurons.

    abstract::M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90272-s

    authors: Marrion NV

    更新日期:1993-07-01 00:00:00

  • A molecular mechanism for stabilization of learning-induced synaptic modifications.

    abstract::Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(03)00874-2

    authors: Quinlan EM,Lebel D,Brosh I,Barkai E

    更新日期:2004-01-22 00:00:00

  • Competing global representations fail to initiate binocular rivalry.

    abstract::A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.08.039

    authors: Carlson TA,He S

    更新日期:2004-09-16 00:00:00

  • The declaration of independence of the neurovascular intimacy.

    abstract::In this issue of Neuron, Oh and Gu (2013) present a model in which intimately related embryonic nerves and blood vessels are patterned independently in response to different guidance cues from a central organizer: the whisker. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2013.09.040

    authors: Chauvet S,Mann F

    更新日期:2013-10-16 00:00:00

  • Low mobility of the Ca2+ buffers in axons of cultured Aplysia neurons.

    abstract::Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the apparent diffusion coefficient (D(app)) of Ca2+, whereas mobile buffers contribute to Ca2+ redistribution. To estimate the impact of the expression of specific Ca2+-b...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)81247-7

    authors: Gabso M,Neher E,Spira ME

    更新日期:1997-03-01 00:00:00

  • The headache of a hyperactive calcium channel.

    abstract::Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.02.015

    authors: Xue M,Rosenmund C

    更新日期:2009-03-12 00:00:00

  • A neural representation of categorization uncertainty in the human brain.

    abstract::The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.01.032

    authors: Grinband J,Hirsch J,Ferrera VP

    更新日期:2006-03-02 00:00:00

  • Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells.

    abstract::Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00246-x

    authors: Kreitzer AC,Regehr WG

    更新日期:2001-03-01 00:00:00

  • Primary structure and functional expression of a mammalian skeletal muscle sodium channel.

    abstract::We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(89)90113-x

    authors: Trimmer JS,Cooperman SS,Tomiko SA,Zhou JY,Crean SM,Boyle MB,Kallen RG,Sheng ZH,Barchi RL,Sigworth FJ

    更新日期:1989-07-01 00:00:00

  • Neuronal Inhibition under the Spotlight.

    abstract::In this issue of Neuron,Lin et al. (2015) report an optical method to precisely manipulate the activity of GABAA receptors by designing a mutant receptor that binds photosensitive compounds. This allows for studying GABAA receptors in situ and represents a valuable tool to investigate how inhibition affects brain phys...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2015.11.014

    authors: Mortensen M,Smart TG

    更新日期:2015-12-02 00:00:00

  • Paradoxical Rules of Spike Train Decoding Revealed at the Sensitivity Limit of Vision.

    abstract::All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mou...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.08.005

    authors: Smeds L,Takeshita D,Turunen T,Tiihonen J,Westö J,Martyniuk N,Seppänen A,Ala-Laurila P

    更新日期:2019-11-06 00:00:00

  • Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.

    abstract::Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.09.029

    authors: Frank CA,Kennedy MJ,Goold CP,Marek KW,Davis GW

    更新日期:2006-11-22 00:00:00

  • Is NMDA receptor-coincidence detection required for learning and memory?

    abstract::The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2012.05.008

    authors: Tabone CJ,Ramaswami M

    更新日期:2012-06-07 00:00:00

  • Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats.

    abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.01.035

    authors: Bäck S,Necarsulmer J,Whitaker LR,Coke LM,Koivula P,Heathward EJ,Fortuno LV,Zhang Y,Yeh CG,Baldwin HA,Spencer MD,Mejias-Aponte CA,Pickel J,Hoffman AF,Spivak CE,Lupica CR,Underhill SM,Amara SG,Domanskyi A,Anttila JE,

    更新日期:2019-04-03 00:00:00

  • A role for ligand-gated ion channels in rod photoreceptor development.

    abstract::Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(04)00141-2

    authors: Young TL,Cepko CL

    更新日期:2004-03-25 00:00:00

  • Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex.

    abstract::Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimula...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.09.032

    authors: Li Q,Ke Y,Chan DC,Qian ZM,Yung KK,Ko H,Arbuthnott GW,Yung WH

    更新日期:2012-12-06 00:00:00

  • Bayesian Computation through Cortical Latent Dynamics.

    abstract::Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.06.012

    authors: Sohn H,Narain D,Meirhaeghe N,Jazayeri M

    更新日期:2019-09-04 00:00:00

  • Regulation of AMPA receptor function by the human memory-associated gene KIBRA.

    abstract::KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.08.017

    authors: Makuch L,Volk L,Anggono V,Johnson RC,Yu Y,Duning K,Kremerskothen J,Xia J,Takamiya K,Huganir RL

    更新日期:2011-09-22 00:00:00

  • Is Alpha Asymmetry a Byproduct or Cause of Spatial Attention? New Evidence Alpha Neurofeedback Controls Measures of Spatial Attention.

    abstract::Cued spatial attention differentially modulates alpha power in attended relative to non-attended brain representations, termed the alpha asymmetry. Yet a causal role for alpha in attention is debated. In this issue of Neuron, Bagherzadeh et al., (2019) utilize neurofeedback to train alpha asymmetry and causally impact...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.12.033

    authors: Jones SR,Sliva DD

    更新日期:2020-02-05 00:00:00

  • Rapid Invariant Encoding of Scene Layout in Human OPA.

    abstract::Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.04.014

    authors: Henriksson L,Mur M,Kriegeskorte N

    更新日期:2019-07-03 00:00:00

  • Calcium signaling in dendrites and spines: practical and functional considerations.

    abstract::Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2008.08.020

    authors: Higley MJ,Sabatini BL

    更新日期:2008-09-25 00:00:00

  • Prefrontal phase locking to hippocampal theta oscillations.

    abstract::The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.02.028

    authors: Siapas AG,Lubenov EV,Wilson MA

    更新日期:2005-04-07 00:00:00

  • Lineage Relationships Do Not Drive MGE/PoA-Derived Interneuron Clustering in the Brain.

    abstract::Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.09.034

    authors: Turrero García M,Mazzola E,Harwell CC

    更新日期:2016-10-05 00:00:00

  • Olfaction: diverse species, conserved principles.

    abstract::Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2005.10.022

    authors: Ache BW,Young JM

    更新日期:2005-11-03 00:00:00

  • Robust microcircuit synchronization by inhibitory connections.

    abstract::Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.12.032

    authors: Szücs A,Huerta R,Rabinovich MI,Selverston AI

    更新日期:2009-02-12 00:00:00

  • Making an effort to listen: mechanical amplification in the ear.

    abstract::The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2008.07.012

    authors: Hudspeth AJ

    更新日期:2008-08-28 00:00:00

  • Electrophysiology of a chick neuronal nicotinic acetylcholine receptor expressed in Xenopus oocytes after cDNA injection.

    abstract::Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90132-8

    authors: Ballivet M,Nef P,Couturier S,Rungger D,Bader CR,Bertrand D,Cooper E

    更新日期:1988-11-01 00:00:00

  • Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex.

    abstract::Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.04.023

    authors: Kaneko M,Stellwagen D,Malenka RC,Stryker MP

    更新日期:2008-06-12 00:00:00

  • A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.

    abstract::In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacological blocker 4-aminopyri...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90273-9

    authors: McCormack K,Joiner WJ,Heinemann SH

    更新日期:1994-02-01 00:00:00

  • GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.

    abstract::Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.02.026

    authors: Cruchaga C,Kauwe JS,Harari O,Jin SC,Cai Y,Karch CM,Benitez BA,Jeng AT,Skorupa T,Carrell D,Bertelsen S,Bailey M,McKean D,Shulman JM,De Jager PL,Chibnik L,Bennett DA,Arnold SE,Harold D,Sims R,Gerrish A,Williams J

    更新日期:2013-04-24 00:00:00