Abstract：
:Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic synaptic transmission as an underlying mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.
journal_name
Neuronjournal_title
Neuronauthors
Xue M,Rosenmund Cdoi
10.1016/j.neuron.2009.02.015subject
Has Abstractpub_date
2009-03-12 00:00:00pages
653-4issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00160-3journal_volume
61pub_type
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