Anterior regions of monkey parietal cortex process visual 3D shape.

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...

journal_title：Neuron

authors： McGinley MJ,Vinck M,Reimer J,Batista-Brito R,Zagha E,Cadwell CR,Tolias AS,Cardin JA,McCormick DA

更新日期：2015-09-23 00:00:00

abstract：VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...

journal_title：Neuron

authors： Harwell CC,Parker PR,Gee SM,Okada A,McConnell SK,Kreitzer AC,Kriegstein AR

更新日期：2012-03-22 00:00:00

abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...

journal_title：Neuron

authors： Kasaragod VB,Hausrat TJ,Schaefer N,Kuhn M,Christensen NR,Tessmer I,Maric HM,Madsen KL,Sotriffer C,Villmann C,Kneussel M,Schindelin H

更新日期：2019-02-20 00:00:00

abstract：:Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zinc superoxide dismutase protein (SOD) or with an expression vector co...

journal_title：Neuron

authors： Greenlund LJ,Deckwerth TL,Johnson EM Jr

更新日期：1995-02-01 00:00:00

abstract：:The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...

journal_title：Neuron

authors： Grinband J,Hirsch J,Ferrera VP

更新日期：2006-03-02 00:00:00

abstract：:Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in...

journal_title：Neuron

authors： Jack CR Jr,Holtzman DM

更新日期：2013-12-18 00:00:00

abstract：:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...

journal_title：Neuron

authors： Kohatsu S,Koganezawa M,Yamamoto D

更新日期：2011-02-10 00:00:00

abstract：:Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...

journal_title：Neuron

authors： Hallböök F,Ibáñez CF,Persson H

更新日期：1991-05-01 00:00:00

abstract：:Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chron...

journal_title：Neuron

authors： Turi GF,Li WK,Chavlis S,Pandi I,O'Hare J,Priestley JB,Grosmark AD,Liao Z,Ladow M,Zhang JF,Zemelman BV,Poirazi P,Losonczy A

更新日期：2019-03-20 00:00:00

abstract：:The primary motor cortex (MI) is regarded as the site for motor control. Occasional reports that MI neurons react to sensory stimuli have either been ignored or attributed to guidance of voluntary movements. Here, we show that MI activation is necessary for the somatic perception of movement of our limbs. We made use ...

journal_title：Neuron

authors： Naito E,Roland PE,Ehrsson HH

更新日期：2002-12-05 00:00:00

abstract：:Signaling classically involves the secretion of diverse molecules that bind specific cell-surface receptors and engage intracellular transduction cascades. Some exceptions-namely, lipophilic agents-can cross plasma membranes to bind intracellular receptors and be carried to the nucleus to regulate transcription. Homeo...

journal_title：Neuron

authors： Prochiantz A,Di Nardo AA

更新日期：2015-03-04 00:00:00

abstract：:The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity ...

journal_title：Neuron

authors： Do-Monte FH,Minier-Toribio A,Quiñones-Laracuente K,Medina-Colón EM,Quirk GJ

更新日期：2017-04-19 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...

journal_title：Neuron

authors： Poulet JF

更新日期：2014-10-22 00:00:00

abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...

journal_title：Neuron

authors： Brunwasser SJ,Hengen KB

更新日期：2020-02-19 00:00:00

abstract：:The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...

journal_title：Neuron

authors： Kantor DB,Kolodkin AL

更新日期：2003-06-19 00:00:00

abstract：:Today we are witnessing a new science of placebo, a complex discipline that encompasses several experimental approaches and translational implications. Modern neurobiological tools have been used to answer important questions in placebo research, such as the top-down modulation of sensory and motor systems as well as ...

journal_title：Neuron

authors： Benedetti F

更新日期：2014-11-05 00:00:00

abstract：:Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms ...

journal_title：Neuron

authors： Korkut C,Li Y,Koles K,Brewer C,Ashley J,Yoshihara M,Budnik V

更新日期：2013-03-20 00:00:00

abstract：:Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...

journal_title：Neuron

authors： Takatoh J,Nelson A,Zhou X,Bolton MM,Ehlers MD,Arenkiel BR,Mooney R,Wang F

更新日期：2013-01-23 00:00:00

abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

journal_title：Neuron

authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

更新日期：2014-09-17 00:00:00

abstract：:Brief bath application of N-methyl-D-aspartate (NMDA) to hippocampal slices produces long-term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age, (2) saturable, (3) induced postsynaptically, (4) reversible, and (5) not associated with a change in paired pulse facilitation. Chemically induced LTD ...

journal_title：Neuron

authors： Lee HK,Kameyama K,Huganir RL,Bear MF

更新日期：1998-11-01 00:00:00

abstract：:Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that ...

journal_title：Neuron

authors： Nguyen-Ba-Charvet KT,Chédotal A

更新日期：2006-05-18 00:00:00

abstract：:The TRPN1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in nematodes. In this issue of Neuron, two papers present evidence that TRPN1 is also required for proprioception in fruit fly larvae and that it is a bona fide mechanoreceptor channel for nematode feedin...

journal_title：Neuron

authors： Wilson RI,Corey DP

更新日期：2010-08-12 00:00:00

abstract：:During development, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. In Drosophila, the Slit protein regulates midline axon crossing through repulsion. To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes....

journal_title：Neuron

authors： Plump AS,Erskine L,Sabatier C,Brose K,Epstein CJ,Goodman CS,Mason CA,Tessier-Lavigne M

更新日期：2002-01-17 00:00:00

abstract：:G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR s...

journal_title：Neuron

authors： Fukuto HS,Ferkey DM,Apicella AJ,Lans H,Sharmeen T,Chen W,Lefkowitz RJ,Jansen G,Schafer WR,Hart AC

更新日期：2004-05-27 00:00:00

abstract：:I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...

journal_title：Neuron

authors： Chen H,Kim LA,Rajan S,Xu S,Goldstein SA

更新日期：2003-09-25 00:00:00

abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...

journal_title：Neuron

authors： Jacoby J,Nath A,Jessen ZF,Schwartz GW

更新日期：2018-12-05 00:00:00

abstract：:bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between th...

journal_title：Neuron

authors： Allan DW,Thor S

更新日期：2003-06-05 00:00:00

abstract：:The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...

journal_title：Neuron

authors： Mann K,Gordon MD,Scott K

更新日期：2013-08-21 00:00:00