Abstract:
:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are often considered a requirement for defining a presynaptic site of action. Nevertheless, some synapses exhibit non-canonical forms of neuromodulation, where release probability is altered without a corresponding change in STP. Here, we identify biophysical mechanisms whereby both canonical and non-canonical presynaptic neuromodulation can occur at the same synapse. At a subset of glutamatergic terminals in prefrontal cortex, GABAB and D1/D5 dopamine receptors suppress release probability with and without canonical increases in short-term facilitation by modulating different aspects of presynaptic CaV function. These findings establish a framework whereby signaling from multiple neuromodulators can converge on presynaptic CaVs to differentially tune release dynamics at the same synapse.
journal_name
Neuronjournal_title
Neuronauthors
Burke KJ Jr,Keeshen CM,Bender KJdoi
10.1016/j.neuron.2018.07.030subject
Has Abstractpub_date
2018-09-05 00:00:00pages
969-984.e7issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30628-7journal_volume
99pub_type
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