Abstract:
:An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These findings suggest a central role for parkin in maintaining dopaminergic neuronal integrity and strengthen the link between AR-JP and the more common sporadic form of Parkinson's disease.
journal_name
Neuronjournal_title
Neuronauthors
Feany MB,Pallanck LJdoi
10.1016/s0896-6273(03)00201-0subject
Has Abstractpub_date
2003-04-10 00:00:00pages
13-6issue
1eissn
0896-6273issn
1097-4199pii
S0896627303002010journal_volume
38pub_type
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