Signal Amplification in Drosophila Olfactory Receptor Neurons.

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00

abstract：:Adaptation or gain control allows sensory neurons to encode diverse stimuli using a limited range of output signals. Rod vision exemplifies a general challenge facing adaptational mechanisms-balancing the benefits of averaging to create a reliable signal for adaptation with the need to adapt rapidly and locally. The s...

journal_title：Neuron

authors： Dunn FA,Rieke F

更新日期：2008-03-27 00:00:00

abstract：:Cigarette smokers tend to drink more alcohol than their nonsmoking peers. In this issue of Neuron, Doyon et al. (2013) found that nicotine-induced increases in stress hormones can augment ethanol self-administration in rats, suggesting that a drug interaction may contribute to this phenomenon. ...

journal_title：Neuron

authors： Britt JP,Bonci A

更新日期：2013-08-07 00:00:00

abstract：:Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...

journal_title：Neuron

authors： Matthews PM,Hampshire A

更新日期：2016-08-03 00:00:00

abstract：:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...

journal_title：Neuron

authors： Tonegawa S,Liu X,Ramirez S,Redondo R

更新日期：2015-09-02 00:00:00

abstract：:We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...

journal_title：Neuron

authors： Neher E,Zucker RS

更新日期：1993-01-01 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...

journal_title：Neuron

authors： Stansfeld CE,Marsh SJ,Gibb AJ,Brown DA

更新日期：1993-04-01 00:00:00

abstract：:Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively ...

journal_title：Neuron

authors： Heck A,Fastenrath M,Ackermann S,Auschra B,Bickel H,Coynel D,Gschwind L,Jessen F,Kaduszkiewicz H,Maier W,Milnik A,Pentzek M,Riedel-Heller SG,Ripke S,Spalek K,Sullivan P,Vogler C,Wagner M,Weyerer S,Wolfsgruber S,de

更新日期：2014-03-05 00:00:00

abstract：:The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...

journal_title：Neuron

authors： Robitaille R

更新日期：1998-10-01 00:00:00

abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

journal_title：Neuron

authors： Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

更新日期：2015-04-22 00:00:00

abstract：:To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...

journal_title：Neuron

authors： Yao WD,Gainetdinov RR,Arbuckle MI,Sotnikova TD,Cyr M,Beaulieu JM,Torres GE,Grant SG,Caron MG

更新日期：2004-02-19 00:00:00

abstract：:In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...

journal_title：Neuron

authors： Yu D,Ponomarev A,Davis RL

更新日期：2004-05-13 00:00:00

abstract：:We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...

journal_title：Neuron

authors： Schmitz D,Schuchmann S,Fisahn A,Draguhn A,Buhl EH,Petrasch-Parwez E,Dermietzel R,Heinemann U,Traub RD

更新日期：2001-09-13 00:00:00

abstract：:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...

journal_title：Neuron

authors： Manns JR,Hopkins RO,Squire LR

更新日期：2003-04-10 00:00:00

abstract：:Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...

journal_title：Neuron

authors： Stanley DA,Adolphs R

更新日期：2013-10-30 00:00:00

abstract：:Motoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic domain of muscle-specific kinase (MuSK), a major component of the agrin receptor. Like MuSK, Tid1 coloca...

journal_title：Neuron

authors： Linnoila J,Wang Y,Yao Y,Wang ZZ

更新日期：2008-11-26 00:00:00

abstract：:Mammals are able to navigate to hidden goal locations by direct routes that may traverse previously unvisited terrain. Empirical evidence suggests that this "vector navigation" relies on an internal representation of space provided by the hippocampal formation. The periodic spatial firing patterns of grid cells in the...

journal_title：Neuron

authors： Bush D,Barry C,Manson D,Burgess N

更新日期：2015-08-05 00:00:00

abstract：:K(ATP) channels are large heteromultimeric complexes containing four subunits from the inwardly rectifying K+ channel family (Kir6.2) and four regulatory sulphonylurea receptor subunits from the ATP-binding cassette (ABC) transporter family (SUR1 and SUR2A/B). The molecular basis for interactions between these two unr...

journal_title：Neuron

authors： Schwappach B,Zerangue N,Jan YN,Jan LY

更新日期：2000-04-01 00:00:00

abstract：:Na+ channels are present at high density in squid giant axon but are absent from its somata in the giant fiber lobe (GFL) of the stellate ganglion. GFL cells dispersed in vitro maintain growing axons and develop a Na+ channel distribution similar to that in vivo. Tunicamycin, a glycosylation inhibitor, selectively dis...

journal_title：Neuron

authors： Gilly WF,Lucero MT,Horrigan FT

更新日期：1990-11-01 00:00:00

abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...

journal_title：Neuron

authors： Li Y,Gao XB,Sakurai T,van den Pol AN

更新日期：2002-12-19 00:00:00

abstract：:It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...

journal_title：Neuron

authors： Cohen Kadosh R,Cohen Kadosh K,Kaas A,Henik A,Goebel R

更新日期：2007-01-18 00:00:00

abstract：:Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...

journal_title：Neuron

authors： Dunaevsky A

更新日期：2004-10-14 00:00:00

abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...

journal_title：Neuron

authors： Porter NM,Twyman RE,Uhler MD,Macdonald RL

更新日期：1990-12-01 00:00:00

abstract：:Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...

journal_title：Neuron

authors： Cho Y,Shin JE,Ewan EE,Oh YM,Pita-Thomas W,Cavalli V

更新日期：2015-11-18 00:00:00

abstract：:Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimila...

journal_title：Neuron

authors： Potenza MN,Sofuoglu M,Carroll KM,Rounsaville BJ

更新日期：2011-02-24 00:00:00

abstract：:The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...

journal_title：Neuron

authors： Gilbert CD,Li W

更新日期：2012-07-26 00:00:00

abstract：:KIBRA has recently been identified as a gene associated with human memory performance. Despite the elucidation of the role of KIBRA in several diverse processes in nonneuronal cells, the molecular function of KIBRA in neurons is unknown. We found that KIBRA directly binds to the protein interacting with C-kinase 1 (PI...

journal_title：Neuron

authors： Makuch L,Volk L,Anggono V,Johnson RC,Yu Y,Duning K,Kremerskothen J,Xia J,Takamiya K,Huganir RL

更新日期：2011-09-22 00:00:00

abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...

journal_title：Neuron

authors： Litt B

更新日期：2015-04-08 00:00:00

abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...

journal_title：Neuron

authors： Yoon KJ,Ming GL,Song H

更新日期：2018-07-25 00:00:00