Abstract:
:Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic integrity is impaired in patients with Alzheimer's disease and in relevant mouse models. It is unknown, however, whether this structural degeneration translates into aberrant neuronal function. Here we use in vivo whole-cell patch-clamp recordings, high-resolution STED imaging, and computational modeling of CA1 pyramidal neurons in a mouse model of Alzheimer's disease to show that structural degeneration and neuronal hyperexcitability are crucially linked. Our results demonstrate that a structure-dependent amplification of synaptic input to action potential output conversion might constitute a novel cellular pathomechanism underlying network dysfunction with potential relevance for other neurodegenerative diseases with abnormal changes of dendritic morphology.
journal_name
Neuronjournal_title
Neuronauthors
Šišková Z,Justus D,Kaneko H,Friedrichs D,Henneberg N,Beutel T,Pitsch J,Schoch S,Becker A,von der Kammer H,Remy Sdoi
10.1016/j.neuron.2014.10.024subject
Has Abstractpub_date
2014-12-03 00:00:00pages
1023-33issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00922-2journal_volume
84pub_type
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