Abstract：
:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response in alert behaving animals. In the oculomotor system, numerous neurons expressing nitric oxide synthase (NOS) are located in the prepositus hypoglossi, a nucleus involved in the control of horizontal eye movements. Unilateral inhibition of NOS within this nucleus results in severe ocular nystagmus with slow phases directed to the contralateral side. Accordingly, local increases of NO or cyclic GMP produced a nystagmus in the opposite direction. It is concluded that a balanced production of NO by prepositus hypoglossi neurons is a necessary condition for the normal performance of eye movements in alert animals.
journal_name
Neuronjournal_title
Neuronauthors
Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada Cdoi
10.1016/s0896-6273(00)80205-6subject
Has Abstractpub_date
1996-10-01 00:00:00pages
739-45issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80205-6journal_volume
17pub_type
杂志文章相关文献
NEURON文献大全abstract：:Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). The gene encoding huntingtin, HTT, and its dominantly inherited mutation were identified more than 20 years ago...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2016.02.003
更新日期：2016-03-02 00:00:00
abstract：:Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.02.029
更新日期：2019-05-08 00:00:00
abstract：:Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.06.006
更新日期：2006-07-20 00:00:00
abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00147-1
更新日期：2000-12-01 00:00:00
abstract：:In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.039
更新日期：2013-06-19 00:00:00
abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.04.002
更新日期：2020-07-08 00:00:00
abstract：:The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90203-4
更新日期：1993-05-01 00:00:00
abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.03.017
更新日期：2012-06-07 00:00:00
abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00200-9
更新日期：2003-05-08 00:00:00
abstract：:von Recklinghausen's neurofibromatosis (NF1) is a common inherited human disease. The events leading to patient symptoms from inheritance of a defective NF1 gene are unknown. Since knowledge of the distribution of the normal NF1 gene product should improve understanding of the pathogenesis of the disease, we raised an...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90270-n
更新日期：1992-03-01 00:00:00
abstract：:Previous work has hinted that prospective and retrospective coding modes exist in hippocampus. Prospective coding is believed to reflect memory retrieval processes, whereas retrospective coding is thought to be important for memory encoding. Here, we show in rats that separate prospective and retrospective modes exist...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.03.013
更新日期：2014-05-07 00:00:00
abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...
journal_title：Neuron
pub_type：
doi：10.1016/j.neuron.2009.09.038
更新日期：2009-10-15 00:00:00
abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90152-x
更新日期：1994-01-01 00:00:00
abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00008-8
更新日期：2000-07-01 00:00:00
abstract：:Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.03.021
更新日期：2018-04-18 00:00:00
abstract：:Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We h...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.10.034
更新日期：2007-12-20 00:00:00
abstract：:beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80179-8
更新日期：1996-09-01 00:00:00
abstract：:A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90161-j
更新日期：1993-04-01 00:00:00
abstract：:Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption of MeCP2 S421 phosph...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.08.022
更新日期：2011-10-06 00:00:00
abstract：:Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.05.020
更新日期：2017-06-21 00:00:00
abstract：:Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive. Monoclonal antibodies in development target both soluble and insoluble Aβ peptide. We h...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.10.029
更新日期：2012-12-06 00:00:00
abstract：:The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.06.032
更新日期：2015-07-15 00:00:00
abstract：:Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development and function is largely unknown. Here, we report biological functions for miR-19 in adult neurogenesis. We determined that miR-19 is enriched in neural progenito...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.05.034
更新日期：2016-07-06 00:00:00
abstract：:The structural plasticity of dendritic spines is considered to be essential for various forms of synaptic plasticity, learning, and memory. The process is mediated by a complex signaling network consisting of numerous species of molecules. Furthermore, the spatiotemporal dynamics of the biochemical signaling are regul...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.05.043
更新日期：2015-07-01 00:00:00
abstract：:A critical feature of neural networks is that they balance excitation and inhibition to prevent pathological dysfunction. How this is achieved is largely unknown, although deficits in the balance contribute to many neurological disorders. We show here that a microRNA (miR-101) is a key orchestrator of this essential f...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.11.017
更新日期：2016-12-21 00:00:00
abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.022
更新日期：2017-07-05 00:00:00
abstract：:Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.12.002
更新日期：2011-12-22 00:00:00
abstract：:The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin prep...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90015-2
更新日期：1995-12-01 00:00:00
abstract：:We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.05.008
更新日期：2017-05-17 00:00:00
abstract：:Mutations in a synaptic organizing pathway contribute to autism. Autism-associated mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are thought to reduce excitatory/inhibitory transmission. However, we show that mutation of Mdga2 elevates excitatory transmission, and that MDGA2 blocks n...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.08.016
更新日期：2016-09-07 00:00:00
