Abstract:
:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dynein functions. Here we characterize NUDEL, a novel LIS1-interacting protein with sequence homology to gene products also implicated in nuclear distribution in fungi. Like LIS1, NUDEL is robustly expressed in brain, enriched at centrosomes and neuronal growth cones, and interacts with cytoplasmic dynein. Furthermore, NUDEL is a substrate of Cdk5, a kinase known to be critical during neuronal migration. Inhibition of Cdk5 modifies NUDEL distribution in neurons and affects neuritic morphology. Our findings point to cross-talk between two prominent pathways that regulate neuronal migration.
journal_name
Neuronjournal_title
Neuronauthors
Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LHdoi
10.1016/s0896-6273(00)00147-1subject
Has Abstractpub_date
2000-12-01 00:00:00pages
697-711issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(00)00147-1journal_volume
28pub_type
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