Abstract：
:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP was associated with recruitment of D2-positive nucleus accumbens medium spiny neurons to fire in the cocaine-paired location, and this recruitment was driven predominantly by selective strengthening of coupling with hippocampal place cells that encode the cocaine-paired location. These findings provide in vivo evidence suggesting that the synaptic potentiation in the accumbens caused by repeated cocaine administration preferentially affects inputs that were active at the time of drug exposure. This provides a potential physiological mechanism by which drug use becomes associated with specific environmental contexts.
journal_name
Neuronjournal_title
Neuronauthors
Sjulson L,Peyrache A,Cumpelik A,Cassataro D,Buzsáki Gdoi
10.1016/j.neuron.2018.04.015subject
Has Abstractpub_date
2018-06-06 00:00:00pages
926-934.e5issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30323-4journal_volume
98pub_type
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