Abstract:
:The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia--a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functional activations in early retinotopic areas. Here we report the surprising finding of a selective object-related abnormality in high-order occipitotemporal cortex. Specifically, we found that face-related cortical areas show a severe disconnection from the amblyopic eye, while building-related regions remain essentially normal. The selectivity of the deficit highlights the differential computations performed in the different object-related areas and is compatible with the suggested association of face regions with analysis of fine detail.
journal_name
Neuronjournal_title
Neuronauthors
Lerner Y,Pianka P,Azmon B,Leiba H,Stolovitch C,Loewenstein A,Harel M,Hendler T,Malach Rdoi
10.1016/s0896-6273(03)00720-7subject
Has Abstractpub_date
2003-12-04 00:00:00pages
1023-9issue
5eissn
0896-6273issn
1097-4199pii
S0896627303007207journal_volume
40pub_type
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