Abstract:
:Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor readers. Prior to instruction, poor readers had significantly lower FA than good readers in a region of the left anterior centrum semiovale. The instruction resulted in a change in white matter (significantly increased FA), and in the very same region. The FA increase was correlated with a decrease in radial diffusivity (but not with a change in axial diffusivity), suggesting that myelination had increased. Furthermore, the FA increase was correlated with improvement in phonological decoding ability, clarifying the cognitive locus of the effect. The results demonstrate the capability of a behavioral intervention to bring about a positive change in cortico-cortical white matter tracts.
journal_name
Neuronjournal_title
Neuronauthors
Keller TA,Just MAdoi
10.1016/j.neuron.2009.10.018subject
Has Abstractpub_date
2009-12-10 00:00:00pages
624-31issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(09)00847-2journal_volume
64pub_type
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