Development of sensory neurons in the absence of NGF/TrkA signaling in vivo.

Abstract:

:The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. All dorsal root ganglion (DRG) neurons that normally die in the absence of NGF/TrkA signaling survive if BAX is also eliminated. These neurons extend axons through the dorsal roots and collateral branches into the dorsal horn. In contrast, superficial cutaneous innervation is absent. Furthermore, rescued sensory neurons fail to express biochemical markers characteristic of the nociceptive phenotype. These findings establish that NGF/TrkA signaling regulates peripheral target field innervation and is required for the full phenotypic differentiation of sensory neurons.

journal_name

Neuron

journal_title

Neuron

authors

Patel TD,Jackman A,Rice FL,Kucera J,Snider WD

doi

10.1016/s0896-6273(00)80899-5

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

345-57

issue

2

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(00)80899-5

journal_volume

25

pub_type

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