Abstract:
:The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. All dorsal root ganglion (DRG) neurons that normally die in the absence of NGF/TrkA signaling survive if BAX is also eliminated. These neurons extend axons through the dorsal roots and collateral branches into the dorsal horn. In contrast, superficial cutaneous innervation is absent. Furthermore, rescued sensory neurons fail to express biochemical markers characteristic of the nociceptive phenotype. These findings establish that NGF/TrkA signaling regulates peripheral target field innervation and is required for the full phenotypic differentiation of sensory neurons.
journal_name
Neuronjournal_title
Neuronauthors
Patel TD,Jackman A,Rice FL,Kucera J,Snider WDdoi
10.1016/s0896-6273(00)80899-5subject
Has Abstractpub_date
2000-02-01 00:00:00pages
345-57issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80899-5journal_volume
25pub_type
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