Abstract:
:The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates exclusively in humans and great apes. Here, we demonstrate the presence of the VEN in the agranular anterior insula of the macaque monkey. The morphology, size, laminar distribution, and proportional distribution of the monkey VEN suggest that it is at least a primal anatomical homolog of the human VEN. This finding sheds new light on the phylogeny of the VEN and AIC. Most importantly, it offers new and much-needed opportunities to investigate the primal connections and physiology of a neuron that could be crucial for human self-awareness, social cognition, and related neuropsychiatric disorders.
journal_name
Neuronjournal_title
Neuronauthors
Evrard HC,Forro T,Logothetis NKdoi
10.1016/j.neuron.2012.03.003subject
Has Abstractpub_date
2012-05-10 00:00:00pages
482-9issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00226-7journal_volume
74pub_type
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