Abstract：
:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly, a transmembrane region 2 determinant for divalent cation permeability also determines argiotoxin sensitivity. Subunit-specific differences in the time courses of block and recovery demonstrate that heteromeric AMPA receptors can assemble in variable ratios. Thus, argiotoxin can be used as a tool in analyzing the subunit composition of AMPA receptors in native membranes.
journal_name
Neuronjournal_title
Neuronauthors
Herlitze S,Raditsch M,Ruppersberg JP,Jahn W,Monyer H,Schoepfer R,Witzemann Vdoi
10.1016/0896-6273(93)90061-usubject
Has Abstractpub_date
1993-06-01 00:00:00pages
1131-40issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(93)90061-Ujournal_volume
10pub_type
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