A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship.

abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...

journal_title：Neuron

authors： Hoover BR,Reed MN,Su J,Penrod RD,Kotilinek LA,Grant MK,Pitstick R,Carlson GA,Lanier LM,Yuan LL,Ashe KH,Liao D

更新日期：2010-12-22 00:00:00

abstract：:We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...

journal_title：Neuron

authors： Milone M,Wang HL,Ohno K,Prince R,Fukudome T,Shen XM,Brengman JM,Griggs RC,Sine SM,Engel AG

更新日期：1998-03-01 00:00:00

abstract：:Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship b...

journal_title：Neuron

authors： Kim BS,Suh GSB

更新日期：2019-12-04 00:00:00

abstract：:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...

journal_title：Neuron

authors： Luo HR,Saiardi A,Nagata E,Ye K,Yu H,Jung TS,Luo X,Jain S,Sawa A,Snyder SH

更新日期：2001-08-16 00:00:00

abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...

journal_title：Neuron

authors： Pribiag H,Lim BK

更新日期：2020-09-23 00:00:00

abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...

journal_title：Neuron

authors： Baden T,Schubert T,Chang L,Wei T,Zaichuk M,Wissinger B,Euler T

更新日期：2013-12-04 00:00:00

abstract：:Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting and overcome many limitations of non-viral tracers. Here, we summarize the viruses that have been developed for neural circuit mapping, and we provide a primer...

journal_title：Neuron

authors： Xu X,Holmes TC,Luo MH,Beier KT,Horwitz GD,Zhao F,Zeng W,Hui M,Semler BL,Sandri-Goldin RM

更新日期：2020-09-23 00:00:00

abstract：:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...

journal_title：Neuron

authors： Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

更新日期：2010-12-09 00:00:00

abstract：:The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...

journal_title：Neuron

authors： Eisen JS

更新日期：1992-02-01 00:00:00

abstract：:Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice and other neurological mutants. As part of an attempt to rescue these mutants by transgenic complementation, we generated normal mouse lines ...

journal_title：Neuron

authors： Readhead C,Schneider A,Griffiths I,Nave KA

更新日期：1994-03-01 00:00:00

abstract：:The TRPN1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in nematodes. In this issue of Neuron, two papers present evidence that TRPN1 is also required for proprioception in fruit fly larvae and that it is a bona fide mechanoreceptor channel for nematode feedin...

journal_title：Neuron

authors： Wilson RI,Corey DP

更新日期：2010-08-12 00:00:00

abstract：:Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...

journal_title：Neuron

authors： Chechik G,Anderson MJ,Bar-Yosef O,Young ED,Tishby N,Nelken I

更新日期：2006-08-03 00:00:00

abstract：:In this issue of Neuron, a study by Baumgartner et al. investigates the influence of oxytocin on trust behavior and its neural mechanisms. The authors report that, following breaches of trust, oxytocin facilitates prosocial behavior while modulating neural signals in the amygdala and caudate nucleus. The findings have...

journal_title：Neuron

authors： Delgado MR

更新日期：2008-05-22 00:00:00

abstract：:Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...

journal_title：Neuron

authors： Wiegert JS,Mahn M,Prigge M,Printz Y,Yizhar O

更新日期：2017-08-02 00:00:00

abstract：:GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...

journal_title：Neuron

authors： Khoshkhoo S,Vogt D,Sohal VS

更新日期：2017-01-18 00:00:00

abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...

journal_title：Neuron

authors： Miller BT,D'Esposito M

更新日期：2005-11-23 00:00:00

abstract：:This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...

journal_title：Neuron

authors： Petersen RS,Panzeri S,Diamond ME

更新日期：2001-11-08 00:00:00

abstract：:A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...

journal_title：Neuron

authors： Mattson MP,Lee RE,Adams ME,Guthrie PB,Kater SB

更新日期：1988-11-01 00:00:00

abstract：:Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...

journal_title：Neuron

authors： Hauk O,Johnsrude I,Pulvermüller F

更新日期：2004-01-22 00:00:00

abstract：:We have cloned a Kv2 potassium channel from squid optic lobe termed sqKv2. Multiple overlapping sqKv2 cDNA clones differed from one another at specific positions by purine transitions. To test whether the purine transitions were generated by RNA editing, we compared a 360 nucleotide genomic sequence with corresponding...

journal_title：Neuron

authors： Patton DE,Silva T,Bezanilla F

更新日期：1997-09-01 00:00:00

abstract：:Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...

journal_title：Neuron

authors： Klein M

更新日期：1994-07-01 00:00:00

abstract：:Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and disease risk. Less is known about the nature, prevalence, and conser...

journal_title：Neuron

authors： Huang WC,Ferris E,Cheng T,Hörndli CS,Gleason K,Tamminga C,Wagner JD,Boucher KM,Christian JL,Gregg C

更新日期：2017-03-08 00:00:00

abstract：:Imaging large-scale circuit dynamics is crucial to understanding brain function, but most techniques have a limited depth of field. Here, we describe volumetric functional ultrasound imaging (vfUSI), a platform for brain-wide vfUSI of hemodynamic activity in awake head-fixed mice. We combined a high-frequency 1,024-ch...

journal_title：Neuron

authors： Brunner C,Grillet M,Sans-Dublanc A,Farrow K,Lambert T,Macé E,Montaldo G,Urban A

更新日期：2020-12-09 00:00:00

abstract：:Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters") that can affect synaptic activity and modulate plasticity. In this study, we used molecular genetic tools, ultra-structural microscopy, and electrophysiology to assess the role of brain-derived neurotrophic factor ...

journal_title：Neuron

authors： Vignoli B,Battistini G,Melani R,Blum R,Santi S,Berardi N,Canossa M

更新日期：2016-11-23 00:00:00

abstract：:Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...

journal_title：Neuron

authors： Wadiche JI,Amara SG,Kavanaugh MP

更新日期：1995-09-01 00:00:00

abstract：:We developed a technology (capturing activated neuronal ensembles [CANE]) to label, manipulate, and transsynaptically trace neural circuits that are transiently activated in behavioral contexts with high efficiency and temporal precision. CANE consists of a knockin mouse and engineered viruses designed to specifically...

journal_title：Neuron

authors： Sakurai K,Zhao S,Takatoh J,Rodriguez E,Lu J,Leavitt AD,Fu M,Han BX,Wang F

更新日期：2016-11-23 00:00:00

abstract：:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...

journal_title：Neuron

authors： Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

更新日期：2005-12-08 00:00:00

abstract：:GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulation of afferents to lateral amygdala, presynaptic GABAbR-mediated inhibition only occurs in glutamatergic inputs to prin...

journal_title：Neuron

authors： Pan BX,Dong Y,Ito W,Yanagawa Y,Shigemoto R,Morozov A

更新日期：2009-03-26 00:00:00

abstract：:The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...

journal_title：Neuron

authors： Miyashiro KY,Beckel-Mitchener A,Purk TP,Becker KG,Barret T,Liu L,Carbonetto S,Weiler IJ,Greenough WT,Eberwine J

更新日期：2003-02-06 00:00:00

abstract：:In the CNS, activity of individual neurons has a small but quantifiable relationship to sensory representations and motor outputs. Coactivation of a few 10s to 100s of neurons can code sensory inputs and behavioral task performance within psychophysical limits. However, in a sea of sensory inputs and demand for comple...

journal_title：Neuron

authors： Ainsworth M,Lee S,Cunningham MO,Traub RD,Kopell NJ,Whittington MA

更新日期：2012-08-23 00:00:00