Abstract：
:Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these questions, we recorded CeA neurons in rats performing a task in which rewards were delivered or omitted unexpectedly. We found that activity in CeA neurons increased selectively at the time of omission and declined again with learning. Increased firing correlated with CeA-inactivation sensitive measures of attention. Notably CeA neurons did not fire to the cues or in response to unexpected rewards. These results indicate that CeA contributes to learning in response to reward omission due to a specific role in signaling actual omission rather than a more general involvement in signaling expectancies, errors, or reward value.
journal_name
Neuronjournal_title
Neuronauthors
Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum Gdoi
10.1016/j.neuron.2010.11.019subject
Has Abstractpub_date
2010-12-09 00:00:00pages
991-1001issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00935-9journal_volume
68pub_type
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