Abstract:
:Viral tracers are important tools for neuroanatomical mapping and genetic payload delivery. Genetically modified viruses allow for cell-type-specific targeting and overcome many limitations of non-viral tracers. Here, we summarize the viruses that have been developed for neural circuit mapping, and we provide a primer on currently applied anterograde and retrograde viral tracers with practical guidance on experimental uses. We also discuss and highlight key technical and conceptual considerations for developing new safer and more effective anterograde trans-synaptic viral vectors for neural circuit analysis in multiple species.
journal_name
Neuronjournal_title
Neuronauthors
Xu X,Holmes TC,Luo MH,Beier KT,Horwitz GD,Zhao F,Zeng W,Hui M,Semler BL,Sandri-Goldin RMdoi
10.1016/j.neuron.2020.07.010subject
Has Abstractpub_date
2020-09-23 00:00:00pages
1029-1047issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30527-4journal_volume
107pub_type
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