Abstract:
:Neural crest cells of vertebrate embryos produce neurons, glia, pigment cells, and connective tissue in vivo and in vitro. To test the developmental potential of apparently undifferentiated crest cells, we have used the monoclonal antibody A2B5, which recognizes a cell surface glycolipid characteristic of neurons, to identify and immunoablate a subpopulation of cultured avian neural crest cells with a neuronal phenotype. Our results indicate that a limited neurogenic precursor subpopulation is present in cultures of avian neural crest cells and that the fate of this subpopulation can be influenced by environmental conditions arising when dispersal of neural crest cells is delayed.
journal_name
Neuronjournal_title
Neuronauthors
Vogel KS,Weston JAdoi
10.1016/0896-6273(88)90106-7subject
Has Abstractpub_date
1988-09-01 00:00:00pages
569-77issue
7eissn
0896-6273issn
1097-4199pii
0896-6273(88)90106-7journal_volume
1pub_type
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