Abstract:
:We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining early visual areas. These include two face-related regions, three object-related regions, and two building-related regions. Interestingly, this complex category-related pattern is organized in a large-scale dorso-ventral mirror symmetry of object category. Furthermore, correlating this pattern to the map of visual field eccentricity, we found that the entire network of areas could be related to a single and unified eccentricity map. We hypothesize that this large-scale organization points to a possible development of high-order object areas through extension and specialization of a single proto-representation.
journal_name
Neuronjournal_title
Neuronauthors
Hasson U,Harel M,Levy I,Malach Rdoi
10.1016/s0896-6273(03)00144-2subject
Has Abstractpub_date
2003-03-27 00:00:00pages
1027-41issue
6eissn
0896-6273issn
1097-4199pii
S0896627303001442journal_volume
37pub_type
杂志文章相关文献
NEURON文献大全abstract::Tau protein undergoes a shift in its molecular mass and its electrophoretic complexity during early postnatal development. We have sequenced a tau cDNA from an adult rat brain expression library and have found two inserted sequences. One of these inserts predicts a fourth repeated sequence homologous to the other thre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90077-9
更新日期:1989-04-01 00:00:00
abstract::In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.10.007
更新日期:2020-10-28 00:00:00
abstract::AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00668-8
更新日期:2003-11-13 00:00:00
abstract::Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external enviro...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.013
更新日期:2018-10-24 00:00:00
abstract::Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated wit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.02.009
更新日期:2008-04-10 00:00:00
abstract::Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00874-2
更新日期:2004-01-22 00:00:00
abstract::Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.10.017
更新日期:2020-01-22 00:00:00
abstract::Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00384-1
更新日期:2001-08-16 00:00:00
abstract::We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00410-x
更新日期:2001-09-13 00:00:00
abstract::bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between th...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00329-5
更新日期:2003-06-05 00:00:00
abstract::Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.032
更新日期:2013-10-30 00:00:00
abstract::In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.003
更新日期:2019-10-23 00:00:00
abstract::Our understanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of APP to generate amyloid-beta (Abeta), is regulated in Alzheimer's disease (AD) remains incomplete. In this issue of Neuron, O'Connor and coworkers show how energy deprivation, a potential risk factor in AD, tr...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.12.010
更新日期:2008-12-26 00:00:00
abstract::In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00223-9
更新日期:2001-02-01 00:00:00
abstract::Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.12.013
更新日期:2020-12-30 00:00:00
abstract::The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the pre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.03.010
更新日期:2019-05-22 00:00:00
abstract::Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.05.016
更新日期:2007-06-07 00:00:00
abstract::Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.01.006
更新日期:2014-01-22 00:00:00
abstract::Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.09.006
更新日期:2020-09-23 00:00:00
abstract::Glial cells respond to neuronal activation and release neuroactive molecules (termed "gliotransmitters") that can affect synaptic activity and modulate plasticity. In this study, we used molecular genetic tools, ultra-structural microscopy, and electrophysiology to assess the role of brain-derived neurotrophic factor ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.09.031
更新日期:2016-11-23 00:00:00
abstract::The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by mot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.11.033
更新日期:2008-01-24 00:00:00
abstract::The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90116-9
更新日期:1993-11-01 00:00:00
abstract::To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.009
更新日期:2007-11-21 00:00:00
abstract::AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00520-7
更新日期:2001-12-06 00:00:00
abstract::In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.12.007
更新日期:2018-01-17 00:00:00
abstract::We have cloned a Kv2 potassium channel from squid optic lobe termed sqKv2. Multiple overlapping sqKv2 cDNA clones differed from one another at specific positions by purine transitions. To test whether the purine transitions were generated by RNA editing, we compared a 360 nucleotide genomic sequence with corresponding...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80383-9
更新日期:1997-09-01 00:00:00
abstract::In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.04.019
更新日期:2019-05-08 00:00:00
abstract::Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.09.001
更新日期:2007-09-20 00:00:00
abstract::Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90173-o
更新日期:1993-04-01 00:00:00
abstract::Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.036
更新日期:2014-06-18 00:00:00