Dynactin is necessary for synapse stabilization.

abstract：:Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...

journal_title：Neuron

authors： Kalil K,Dent EW

更新日期：2004-06-24 00:00:00

abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...

journal_title：Neuron

authors： Sjulson L,Peyrache A,Cumpelik A,Cassataro D,Buzsáki G

更新日期：2018-06-06 00:00:00

abstract：:Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly unders...

journal_title：Neuron

authors： Krüttner S,Stepien B,Noordermeer JN,Mommaas MA,Mechtler K,Dickson BJ,Keleman K

更新日期：2012-10-18 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...

journal_title：Neuron

authors： Giasson BI,Lee VM

更新日期：2001-09-27 00:00:00

abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...

journal_title：Neuron

authors： Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

更新日期：2008-09-25 00:00:00

abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...

journal_title：Neuron

authors： Nicholson-Fish JC,Kokotos AC,Gillingwater TH,Smillie KJ,Cousin MA

更新日期：2015-12-02 00:00:00

abstract：:We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...

journal_title：Neuron

authors： Trimmer JS,Cooperman SS,Tomiko SA,Zhou JY,Crean SM,Boyle MB,Kallen RG,Sheng ZH,Barchi RL,Sigworth FJ

更新日期：1989-07-01 00:00:00

abstract：:Zika virus (ZIVK) represents a new threat to global health, with particular relevance to neuroscientists, due to associated newborn and adult neurological disease. Consequences of vertical infection include microcephaly with brain and eye anomalies, and consequences of adult infection include Guillain-Barré syndrome (...

journal_title：Neuron

authors： Li H,Saucedo-Cuevas L,Shresta S,Gleeson JG

更新日期：2016-12-07 00:00:00

abstract：:As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...

journal_title：Neuron

authors： Tsai PS,Friedman B,Ifarraguerri AI,Thompson BD,Lev-Ram V,Schaffer CB,Xiong Q,Tsien RY,Squier JA,Kleinfeld D

更新日期：2003-07-03 00:00:00

abstract：:Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...

journal_title：Neuron

authors： Delmas P,Coste B,Gamper N,Shapiro MS

更新日期：2005-07-21 00:00:00

abstract：:In this issue of Neuron, Viader et al. (2013) report on the production of toxic lipids by Schwann cells deficient in mitochondrial respiration, which are capable of destroying neighboring axons. This may have implications for understanding the neurobiology and treatment of mitochondrial neuropathies. ...

journal_title：Neuron

authors： Di Paolo G,Przedborski S

更新日期：2013-03-06 00:00:00

abstract：:Recent binding studies in the central nervous system and other tissues provide evidence that the mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin-B (NMB), exert their numerous physiological effects through at least two different receptors. We describe the structure and expression of a c...

journal_title：Neuron

authors： Wada E,Way J,Shapira H,Kusano K,Lebacq-Verheyden AM,Coy D,Jensen R,Battery J

更新日期：1991-03-01 00:00:00

abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

journal_title：Neuron

authors： Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

更新日期：2012-02-23 00:00:00

abstract：:Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

journal_title：Neuron

authors： Bhave G,Gereau RW 4th

更新日期：2003-08-14 00:00:00

abstract：:The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...

journal_title：Neuron

authors： Zuchero YJ,Chen X,Bien-Ly N,Bumbaca D,Tong RK,Gao X,Zhang S,Hoyte K,Luk W,Huntley MA,Phu L,Tan C,Kallop D,Weimer RM,Lu Y,Kirkpatrick DS,Ernst JA,Chih B,Dennis MS,Watts RJ

更新日期：2016-01-06 00:00:00

abstract：:The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, ...

journal_title：Neuron

authors： Strother JA,Wu ST,Wong AM,Nern A,Rogers EM,Le JQ,Rubin GM,Reiser MB

更新日期：2017-04-05 00:00:00

abstract：:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...

journal_title：Neuron

authors： Burke KJ Jr,Keeshen CM,Bender KJ

更新日期：2018-09-05 00:00:00

abstract：:The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate wer...

journal_title：Neuron

authors： del Pilar Gomez M,Nasi E

更新日期：1995-09-01 00:00:00

abstract：:Cortical development depends upon tightly controlled cell fate and cell survival decisions that generate a functional neuronal population, but the coordination of these two processes is poorly understood. Here we show that conditional removal of a key apical complex protein, Pals1, causes premature withdrawal from the...

journal_title：Neuron

authors： Kim S,Lehtinen MK,Sessa A,Zappaterra MW,Cho SH,Gonzalez D,Boggan B,Austin CA,Wijnholds J,Gambello MJ,Malicki J,LaMantia AS,Broccoli V,Walsh CA

更新日期：2010-04-15 00:00:00

abstract：:Native glutamate receptor ion channels are tetrameric assemblies containing two or more different subunits. NMDA receptors are obligate heteromers formed by coassembly of two or three divergent gene families. While some AMPA and kainate receptors can form functional homomeric ion channels, the KA1 and KA2 subunits are...

journal_title：Neuron

authors： Kumar J,Schuck P,Mayer ML

更新日期：2011-07-28 00:00:00

abstract：:A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...

journal_title：Neuron

authors： Australian Brain Alliance Steering Committee.

更新日期：2016-11-02 00:00:00

abstract：:The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16...

journal_title：Neuron

authors： Gu X,Greiner ER,Mishra R,Kodali R,Osmand A,Finkbeiner S,Steffan JS,Thompson LM,Wetzel R,Yang XW

更新日期：2009-12-24 00:00:00

abstract：:We have devised a simple bioassay for the identification of molecules that inhibit growth cone motility. Chick dorsal root ganglion (DRG) growth cones extending on laminin collapse when exposed to a suspension of embryonic brain membranes. Detergent-solubilized membranes from which the detergent has been removed colla...

journal_title：Neuron

authors： Raper JA,Kapfhammer JP

更新日期：1990-01-01 00:00:00

abstract：:Neuropeptides activate G protein-coupled receptors to acutely modulate cellular excitability and synaptic transmission. However, due to the lack of reagents for precise delivery of peptides within dense brain tissue, the spatiotemporal scale over which neuropeptides act is unknown. To achieve rapid and spatially delim...

journal_title：Neuron

authors： Banghart MR,Sabatini BL

更新日期：2012-01-26 00:00:00

abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...

journal_title：Neuron

authors： Divakaruni SS,Van Dyke AM,Chandra R,LeGates TA,Contreras M,Dharmasri PA,Higgs HN,Lobo MK,Thompson SM,Blanpied TA

更新日期：2018-11-21 00:00:00

abstract：:In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an ...

journal_title：Neuron

authors： Michaud JP,Rivest S

更新日期：2015-02-04 00:00:00

abstract：:Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis. Here, we identify the SEC4 ortholog RAB3 and it...

journal_title：Neuron

authors： Persoon CM,Hoogstraaten RI,Nassal JP,van Weering JRT,Kaeser PS,Toonen RF,Verhage M

更新日期：2019-12-18 00:00:00

abstract：:Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...

journal_title：Neuron

authors： Grubb MS,Rossi FM,Changeux JP,Thompson ID

更新日期：2003-12-18 00:00:00

abstract：:Neural processing at most stages of the primate visual system is modulated by selective attention, such that behaviorally relevant information is emphasized at the expenses of irrelevant, potentially distracting information. The form of attention best understood at the cellular level is when stimuli at a given locatio...

journal_title：Neuron

authors： Mirabella G,Bertini G,Samengo I,Kilavik BE,Frilli D,Della Libera C,Chelazzi L

更新日期：2007-04-19 00:00:00

abstract：:Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...

journal_title：Neuron

authors： Takatoh J,Nelson A,Zhou X,Bolton MM,Ehlers MD,Arenkiel BR,Mooney R,Wang F

更新日期：2013-01-23 00:00:00