Abstract:
:At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to understand how these compartments are structurally registered and functionally integrated with one another. This review will describe the organization of each compartment and then discuss their alignment across pre- and postsynaptic cells at a nanometer scale. We propose that this architecture may allow for precise synaptic information exchange and may be modulated to contribute to the remarkable plasticity of brain function.
journal_name
Neuronjournal_title
Neuronauthors
Biederer T,Kaeser PS,Blanpied TAdoi
10.1016/j.neuron.2017.10.006subject
Has Abstractpub_date
2017-11-01 00:00:00pages
680-696issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30935-2journal_volume
96pub_type
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