Dynamic encoding of perception, memory, and movement in a C. elegans chemotaxis circuit.

abstract：:Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...

journal_title：Neuron

authors： Baek ST,Kerjan G,Bielas SL,Lee JE,Fenstermaker AG,Novarino G,Gleeson JG

更新日期：2014-06-18 00:00:00

abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...

journal_title：Neuron

authors： Udeochu J,Sayed FA,Gan L

更新日期：2018-03-07 00:00:00

abstract：:The primary motor cortex (MI) is regarded as the site for motor control. Occasional reports that MI neurons react to sensory stimuli have either been ignored or attributed to guidance of voluntary movements. Here, we show that MI activation is necessary for the somatic perception of movement of our limbs. We made use ...

journal_title：Neuron

authors： Naito E,Roland PE,Ehrsson HH

更新日期：2002-12-05 00:00:00

abstract：:Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...

journal_title：Neuron

authors： Beech DJ,Bernheim L,Hille B

更新日期：1992-01-01 00:00:00

abstract：:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...

journal_title：Neuron

authors： Benton R

更新日期：2011-02-10 00:00:00

abstract：:A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-tracing assays in developing zebrafish embryos to reconstruct entire retinal lineage...

journal_title：Neuron

authors： He J,Zhang G,Almeida AD,Cayouette M,Simons BD,Harris WA

更新日期：2012-09-06 00:00:00

abstract：:The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG...

journal_title：Neuron

authors： Nakamura K,Hara N,Kouider S,Takayama Y,Hanajima R,Sakai K,Ugawa Y

更新日期：2006-11-09 00:00:00

abstract：:The establishment of spinal motor neuron subclass diversity is achieved through developmental programs that are aligned with the organization of muscle targets in the limb. The evolutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remains unclear how the specification of digit...

journal_title：Neuron

authors： Mendelsohn AI,Dasen JS,Jessell TM

更新日期：2017-02-22 00:00:00

abstract：:The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...

journal_title：Neuron

authors： Murphy TH,Baraban JM,Wier WG

更新日期：1995-07-01 00:00:00

abstract：:Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...

journal_title：Neuron

authors： Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba K

更新日期：1992-12-01 00:00:00

abstract：:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...

journal_title：Neuron

authors： Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MS

更新日期：2013-09-04 00:00:00

abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...

journal_title：Neuron

authors： Moore SJ,Cooper DC,Spruston N

更新日期：2009-01-29 00:00:00

abstract：:The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...

journal_title：Neuron

authors： Pape HC

更新日期：2010-08-26 00:00:00

abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...

journal_title：Neuron

authors： Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

更新日期：1996-10-01 00:00:00

abstract：:The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI...

journal_title：Neuron

authors： Che A,Babij R,Iannone AF,Fetcho RN,Ferrer M,Liston C,Fishell G,De Marco García NV

更新日期：2018-07-11 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...

journal_title：Neuron

authors： Tanimura A,Du Y,Kondapalli J,Wokosin DL,Surmeier DJ

更新日期：2019-02-06 00:00:00

abstract：:Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...

journal_title：Neuron

authors： Graziano MS,Taylor CS,Moore T,Cooke DF

更新日期：2002-10-24 00:00:00

abstract：:The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...

journal_title：Neuron

authors： Forman MS,Lee VM,Trojanowski JQ

更新日期：2005-08-18 00:00:00

abstract：:Recent evidence has challenged the view that memories are made permanent by a consolidation process that happens just once and instead have suggested that memories are "re-consolidated" after reminders. The current findings of Morris et al. in this issue of Neuron suggest that reconsolidation may involve a complex int...

journal_title：Neuron

authors： Eichenbaum H

更新日期：2006-05-04 00:00:00

abstract：:The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slow oscillation in thalamocortical (TC) neurons is largely a passive reflection of neocortical activity. Here we show, however, tha...

journal_title：Neuron

authors： Hughes SW,Cope DW,Blethyn KL,Crunelli V

更新日期：2002-03-14 00:00:00

abstract：:AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...

journal_title：Neuron

authors： Patneau DK,Mayer ML

更新日期：1991-05-01 00:00:00

abstract：:The mechanism of kainate receptor targeting and clustering is still unresolved. Here, we demonstrate that members of the SAP90/PSD-95 family colocalize and associate with kainate receptors. SAP90 and SAP102 coimmunoprecipitate with both KA2 and GluR6, but only SAP97 coimmunoprecipitates with GluR6. Similar to NMDA rec...

journal_title：Neuron

authors： Garcia EP,Mehta S,Blair LA,Wells DG,Shang J,Fukushima T,Fallon JR,Garner CC,Marshall J

更新日期：1998-10-01 00:00:00

abstract：:An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the i...

journal_title：Neuron

authors： Diedrichsen J,King M,Hernandez-Castillo C,Sereno M,Ivry RB

更新日期：2019-06-05 00:00:00

abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...

journal_title：Neuron

authors： Dyhrfjeld-Johnsen J,Soltesz I

更新日期：2004-10-28 00:00:00

abstract：:In humans the hippocampus is required for episodic memory, which extends into the spatial and temporal domains. Work on the rodent hippocampus has shown that NMDA receptor (NMDAR) -mediated plasticity is essential for spatial memory. Here, we have examined whether hippocampal NMDARs are also needed for temporal memory...

journal_title：Neuron

authors： Huerta PT,Sun LD,Wilson MA,Tonegawa S

更新日期：2000-02-01 00:00:00

abstract：:In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined ...

journal_title：Neuron

authors： Phillips HS,Hains JM,Armanini M,Laramee GR,Johnson SA,Winslow JW

更新日期：1991-11-01 00:00:00

abstract：:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...

journal_title：Neuron

authors： Luo HR,Saiardi A,Nagata E,Ye K,Yu H,Jung TS,Luo X,Jain S,Sawa A,Snyder SH

更新日期：2001-08-16 00:00:00

abstract：:In stable environments, decision makers can exploit their previously learned strategies for optimal outcomes, while exploration might lead to better options in unstable environments. Here, to investigate the cortical contributions to exploratory behavior, we analyzed single-neuron activity recorded from four different...

journal_title：Neuron

authors： Donahue CH,Seo H,Lee D

更新日期：2013-10-02 00:00:00

abstract：:Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by...

journal_title：Neuron

authors： Adelman JP,Shen KZ,Kavanaugh MP,Warren RA,Wu YN,Lagrutta A,Bond CT,North RA

更新日期：1992-08-01 00:00:00

abstract：:Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...

journal_title：Neuron

authors： Stanco A,Pla R,Vogt D,Chen Y,Mandal S,Walker J,Hunt RF,Lindtner S,Erdman CA,Pieper AA,Hamilton SP,Xu D,Baraban SC,Rubenstein JL

更新日期：2014-12-03 00:00:00