Abstract：
:Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by the substitution of blocks of amino acids at five identified positions within the putative intracellular region between residues 327 and 797. Excised inside-out membrane patches showed potassium channel openings only with micromolar calcium present at the cytoplasmic side; activity increased steeply both with depolarization and with increasing calcium concentration. The single-channel conductance was 126 pS with symmetrical potassium concentrations. The mean open time of the channels was clearly different for channels having different substituent blocks of amino acids. The results suggest that alternative splicing gives rise to a large family of functionally diverse, calcium-activated potassium channels.
journal_name
Neuronjournal_title
Neuronauthors
Adelman JP,Shen KZ,Kavanaugh MP,Warren RA,Wu YN,Lagrutta A,Bond CT,North RAdoi
10.1016/0896-6273(92)90160-fsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
209-16issue
2eissn
0896-6273issn
1097-4199pii
0896-6273(92)90160-Fjournal_volume
9pub_type
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