Abstract：
:The establishment of spinal motor neuron subclass diversity is achieved through developmental programs that are aligned with the organization of muscle targets in the limb. The evolutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remains unclear how the specification of digit-innervating motor neuron subtypes parallels the elaboration of digits. We show that digit-innervating motor neurons can be defined by selective gene markers and distinguished from other LMC neurons by the expression of a variant Hox gene repertoire and by the failure to express a key enzyme involved in retinoic acid synthesis. This divergent developmental program is sufficient to induce the specification of digit-innervating motor neurons, emphasizing the specialized status of digit control in the evolution of skilled motor behaviors. Our findings suggest that the emergence of digits in the limb is matched by distinct mechanisms for specifying motor neurons that innervate digit muscles.
journal_name
Neuronjournal_title
Neuronauthors
Mendelsohn AI,Dasen JS,Jessell TMdoi
10.1016/j.neuron.2017.01.017subject
Has Abstractpub_date
2017-02-22 00:00:00pages
792-805.e4issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30041-7journal_volume
93pub_type
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