Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.

abstract：:Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...

journal_title：Neuron

authors： Müller M,Genç Ö,Davis GW

更新日期：2015-03-04 00:00:00

abstract：:C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that a...

journal_title：Neuron

authors： Iwasaki K,Staunton J,Saifee O,Nonet M,Thomas JH

更新日期：1997-04-01 00:00:00

abstract：:Fear is a graded central motive state ranging from mild to intense. As threat intensity increases, fear transitions from discriminative to generalized. The circuit mechanisms that process threats of different intensity are not well resolved. Here, we isolate a unique population of locally projecting neurons in the cen...

journal_title：Neuron

authors： Sanford CA,Soden ME,Baird MA,Miller SM,Schulkin J,Palmiter RD,Clark M,Zweifel LS

更新日期：2017-01-04 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. Here, we report that mice with a Bmal1 deletion specific to arginine vasopressin (AVP)-producing neurons showed marked lengthening in the free-running period and activity time of...

journal_title：Neuron

authors： Mieda M,Ono D,Hasegawa E,Okamoto H,Honma K,Honma S,Sakurai T

更新日期：2015-03-04 00:00:00

abstract：:Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed using cultured cells or fresh tissue slices. Based on the pattern of response to kainate, glutamate, and quisqualate, three functionally different kainate-activa...

journal_title：Neuron

authors： Pruss RM,Akeson RL,Racke MM,Wilburn JL

更新日期：1991-09-01 00:00:00

abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...

journal_title：Neuron

authors： Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

更新日期：1990-02-01 00:00:00

abstract：:Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynap...

journal_title：Neuron

authors： Kreitzer AC,Regehr WG

更新日期：2001-03-01 00:00:00

abstract：:The debate over the nature of mechanisms leading to the establishment of synaptic specificity has engaged neuroscientists for the best part of a century. In this issue of Neuron, Balaskas et al. (2019) provide new evidence in favor of the role of positional strategies in the organization of sensory-motor circuits. ...

journal_title：Neuron

authors： Mariotti L,Tripodi M

更新日期：2019-06-19 00:00:00

abstract：:Opioid neuropeptides and their receptors are evolutionarily conserved neuromodulatory systems that profoundly influence behavior. In dorsal striatum, which expresses the endogenous opioid enkephalin, patches (or striosomes) are limbic-associated subcompartments enriched in mu opioid receptors. The functional implicati...

journal_title：Neuron

authors： Banghart MR,Neufeld SQ,Wong NC,Sabatini BL

更新日期：2015-12-16 00:00:00

abstract：:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...

journal_title：Neuron

authors： Hyman BT

更新日期：2014-06-18 00:00:00

abstract：:Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...

journal_title：Neuron

authors： Brunwasser SJ,Hengen KB

更新日期：2020-02-19 00:00:00

abstract：:We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cas...

journal_title：Neuron

authors： Pocklington AJ,Rees E,Walters JT,Han J,Kavanagh DH,Chambert KD,Holmans P,Moran JL,McCarroll SA,Kirov G,O'Donovan MC,Owen MJ

更新日期：2015-06-03 00:00:00

abstract：:We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

journal_title：Neuron

authors： Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

更新日期：1990-08-01 00:00:00

abstract：:Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol ph...

journal_title：Neuron

authors： Wenk MR,Pellegrini L,Klenchin VA,Di Paolo G,Chang S,Daniell L,Arioka M,Martin TF,De Camilli P

更新日期：2001-10-11 00:00:00

abstract：:Huntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. The mechanisms underlying HDL2 pathogenesis remain unclear. Here we developed a BAC transgenic mouse model of HDL2 (BAC-HDL2) that exhibits progressive motor deficits, select...

journal_title：Neuron

authors： Wilburn B,Rudnicki DD,Zhao J,Weitz TM,Cheng Y,Gu X,Greiner E,Park CS,Wang N,Sopher BL,La Spada AR,Osmand A,Margolis RL,Sun YE,Yang XW

更新日期：2011-05-12 00:00:00

abstract：:Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...

journal_title：Neuron

authors： Hasan MT,Althammer F,Silva da Gouveia M,Goyon S,Eliava M,Lefevre A,Kerspern D,Schimmer J,Raftogianni A,Wahis J,Knobloch-Bollmann HS,Tang Y,Liu X,Jain A,Chavant V,Goumon Y,Weislogel JM,Hurlemann R,Herpertz SC,Pitzer

更新日期：2019-07-03 00:00:00

abstract：:The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autis...

journal_title：Neuron

authors： Samuels IS,Saitta SC,Landreth GE

更新日期：2009-01-29 00:00:00

abstract：:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...

journal_title：Neuron

authors： Gonzalez-Castillo J,Bandettini PA

更新日期：2015-06-17 00:00:00

abstract：:Type IIA rat brain Na+ channel alpha subunits were expressed in CHO cells by nuclear microinjection or by transfection using a vector containing both metallothionein and bacteriophage SP6 promoters. Stable cell lines expressing Na+ channels were isolated, and whole-cell Na+ currents of 0.9-14 nA were recorded. The mea...

journal_title：Neuron

authors： West JW,Scheuer T,Maechler L,Catterall WA

更新日期：1992-01-01 00:00:00

abstract：:Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...

journal_title：Neuron

authors： Franks KM,Isaacson JS

更新日期：2006-02-02 00:00:00

abstract：:Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...

journal_title：Neuron

authors： Zhao Y,Sivaji S,Chiang MC,Ali H,Zukowski M,Ali S,Kennedy B,Sklyar A,Cheng A,Guo Z,Reed AK,Kodali R,Borowski J,Frost G,Beukema P,Wills ZP

更新日期：2017-10-11 00:00:00

abstract：:In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...

journal_title：Neuron

authors： Subramanian J,Nedivi E

更新日期：2016-07-20 00:00:00

abstract：:The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...

journal_title：Neuron

authors： Sucher NJ,Deitcher DL

更新日期：1995-06-01 00:00:00

abstract：:Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...

journal_title：Neuron

authors： Fruttiger M,Calver AR,Krüger WH,Mudhar HS,Michalovich D,Takakura N,Nishikawa S,Richardson WD

更新日期：1996-12-01 00:00:00

abstract：:Neural ensembles oscillate across a broad range of frequencies and are transiently coupled or "bound" together when people attend to a stimulus, perceive, think, and act. This is a dynamic, self-assembling process, with parts of the brain engaging and disengaging in time. But how is it done? The theory of Coordination...

journal_title：Neuron

authors： Tognoli E,Kelso JA

更新日期：2014-01-08 00:00:00

abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

journal_title：Neuron

authors： Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

更新日期：2007-09-20 00:00:00

abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

journal_title：Neuron

authors： Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

更新日期：2000-12-01 00:00:00

abstract：:Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we describe and validate a compound that reveals neuronal connections in vivo, using MRI. The classic anatomical tracer CTB (cholera-toxin subunit-B) was conjugate...

journal_title：Neuron

authors： Wu CW,Vasalatiy O,Liu N,Wu H,Cheal S,Chen DY,Koretsky AP,Griffiths GL,Tootell RB,Ungerleider LG

更新日期：2011-04-28 00:00:00

abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

journal_title：Neuron

authors： Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

更新日期：2006-01-05 00:00:00

abstract：:Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...

journal_title：Neuron

authors： Nathanson JA,Scavone C,Scanlon C,McKee M

更新日期：1995-04-01 00:00:00