Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.

abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...

journal_title：Neuron

authors： Yoon KJ,Ming GL,Song H

更新日期：2018-07-25 00:00:00

abstract：:The controversy about whether dopamine contributes to cell loss in Parkinson's disease takes a new turn as Mosharov et al. in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons. ...

journal_title：Neuron

authors： Surmeier DJ

更新日期：2009-04-30 00:00:00

abstract：:DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to develop a new Gi-coupled DREADD using the kappa-opioid receptor as a template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB)...

journal_title：Neuron

authors： Vardy E,Robinson JE,Li C,Olsen RHJ,DiBerto JF,Giguere PM,Sassano FM,Huang XP,Zhu H,Urban DJ,White KL,Rittiner JE,Crowley NA,Pleil KE,Mazzone CM,Mosier PD,Song J,Kash TL,Malanga CJ,Krashes MJ,Roth BL

更新日期：2015-05-20 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...

journal_title：Neuron

authors： Edbauer D,Neilson JR,Foster KA,Wang CF,Seeburg DP,Batterton MN,Tada T,Dolan BM,Sharp PA,Sheng M

更新日期：2010-02-11 00:00:00

abstract：:The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...

journal_title：Neuron

authors： Pearson RA,Ali RR

更新日期：2018-11-07 00:00:00

abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...

journal_title：Neuron

authors： Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

更新日期：1990-02-01 00:00:00

abstract：:According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...

journal_title：Neuron

authors： Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

更新日期：2009-11-12 00:00:00

abstract：:Voltage-activated potassium (Kv) channels from mammalian brain are hetero-oligomers containing alpha and beta subunits. Coexpression of Kv1 alpha and Kv beta 1 subunits confers rapid A-type inactivation on noninactivating potassium channels (delayed rectifiers) in expression systems in vitro. We have delineated a Kv1....

journal_title：Neuron

authors： Sewing S,Roeper J,Pongs O

更新日期：1996-02-01 00:00:00

abstract：:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...

journal_title：Neuron

authors： Barnhart EL,Wang IE,Wei H,Desplan C,Clandinin TR

更新日期：2018-10-10 00:00:00

abstract：:Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the ...

journal_title：Neuron

authors： Vlasits AL,Bos R,Morrie RD,Fortuny C,Flannery JG,Feller MB,Rivlin-Etzion M

更新日期：2014-09-03 00:00:00

abstract：:Visual attention has been classically described as a spotlight that enhances the processing of a behaviorally relevant object. However, in many situations, humans and animals must simultaneously attend to several relevant objects separated by distracters. To account for this ability, various models of attention have b...

journal_title：Neuron

authors： Niebergall R,Khayat PS,Treue S,Martinez-Trujillo JC

更新日期：2011-12-22 00:00:00

abstract：:The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and opt...

journal_title：Neuron

authors： Teeters JL,Godfrey K,Young R,Dang C,Friedsam C,Wark B,Asari H,Peron S,Li N,Peyrache A,Denisov G,Siegle JH,Olsen SR,Martin C,Chun M,Tripathy S,Blanche TJ,Harris K,Buzsáki G,Koch C,Meister M,Svoboda K,Sommer FT

更新日期：2015-11-18 00:00:00

abstract：:The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...

journal_title：Neuron

authors： Singer AC,Carr MF,Karlsson MP,Frank LM

更新日期：2013-03-20 00:00:00

abstract：:Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes. One of the septins...

journal_title：Neuron

authors： Hsu SC,Hazuka CD,Roth R,Foletti DL,Heuser J,Scheller RH

更新日期：1998-06-01 00:00:00

abstract：:In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...

journal_title：Neuron

authors： Koulakov AA,Chklovskii DB

更新日期：2001-02-01 00:00:00

abstract：:The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the ne...

journal_title：Neuron

authors： Medalla M,Barbas H

更新日期：2009-02-26 00:00:00

abstract：:Perception of the thermal environment begins with the activation of peripheral thermosensory neurons innervating the body surface. To understand how temperature is represented in vivo, we used genetically encoded calcium indicators to measure temperature-evoked responses in hundreds of neurons across the trigeminal ga...

journal_title：Neuron

authors： Yarmolinsky DA,Peng Y,Pogorzala LA,Rutlin M,Hoon MA,Zuker CS

更新日期：2016-12-07 00:00:00

abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...

journal_title：Neuron

authors： Waters J

更新日期：2009-03-26 00:00:00

abstract：:TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-relat...

journal_title：Neuron

authors： Xu XZ,Chien F,Butler A,Salkoff L,Montell C

更新日期：2000-06-01 00:00:00

abstract：:Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...

journal_title：Neuron

authors： Romo R,Hernández A,Zainos A,Brody CD,Lemus L

更新日期：2000-04-01 00:00:00

abstract：:Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...

journal_title：Neuron

authors： Thompson WJ

更新日期：2001-08-16 00:00:00

abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...

journal_title：Neuron

authors： Flucher BE,Morton ME,Froehner SC,Daniels MP

更新日期：1990-09-01 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...

journal_title：Neuron

authors： Panayotis N,Fainzilber M

更新日期：2019-05-08 00:00:00

abstract：:The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...

journal_title：Neuron

authors： Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJ

更新日期：2000-05-01 00:00:00

abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...

journal_title：Neuron

authors： Wolozin B

更新日期：2004-01-08 00:00:00

abstract：:Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...

journal_title：Neuron

authors： Xue M,Rosenmund C

更新日期：2009-03-12 00:00:00

abstract：:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...

journal_title：Neuron

authors： Feldman DE

更新日期：2000-07-01 00:00:00

abstract：:From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...

journal_title：Neuron

authors： Lampl I,Anderson JS,Gillespie DC,Ferster D

更新日期：2001-04-01 00:00:00

abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...

journal_title：Neuron

authors： Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

更新日期：2010-01-14 00:00:00