Abstract:
:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially constrained network properties. From these preliminary results a glimmer of hope in uncovering deep principles of brain organization begins to emerge.
journal_name
Neuronjournal_title
Neuronauthors
Gonzalez-Castillo J,Bandettini PAdoi
10.1016/j.neuron.2015.06.006subject
Has Abstractpub_date
2015-06-17 00:00:00pages
1327-9issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00519-Xjournal_volume
86pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::Gamma-frequency oscillations (GFOs, >40 Hz) are a general network signature at seizure onset at all stages of development, with possible deleterious consequences in the immature brain. At early developmental stages, the simultaneous occurrence of GFOs in different brain regions suggests the existence of a long-ranging...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.01.026
更新日期:2012-04-12 00:00:00
abstract::Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.12.003
更新日期:2013-12-18 00:00:00
abstract::Anteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expression of Hoxb4 and found that transient signaling from the paraxial mesoderm induces expression in the hindbrain. Induction i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80513-9
更新日期:1998-07-01 00:00:00
abstract::Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(02)00631-1
更新日期:2002-03-14 00:00:00
abstract::The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving cerebellum and retina. Purkinje cell death in pcd is dramatic, as >99% of Purkinje neurons are lost in 3 weeks. Loss of function of Nna1 causes pcd, and Nna1 is a highly conserved zinc carboxypeptidase. To determine the bas...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.05.024
更新日期:2010-06-24 00:00:00
abstract::We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.032
更新日期:2005-08-04 00:00:00
abstract::Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80053-7
更新日期:1996-02-01 00:00:00
abstract::During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81034-x
更新日期:1999-12-01 00:00:00
abstract::The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.06.002
更新日期:2005-06-16 00:00:00
abstract::In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00217-x
更新日期:2004-05-13 00:00:00
abstract::Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00298-7
更新日期:2001-05-01 00:00:00
abstract::Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2010.08.028
更新日期:2010-09-09 00:00:00
abstract::Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.12.012
更新日期:2016-12-21 00:00:00
abstract::Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.08.024
更新日期:2017-09-13 00:00:00
abstract::The establishment of spinal motor neuron subclass diversity is achieved through developmental programs that are aligned with the organization of muscle targets in the limb. The evolutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remains unclear how the specification of digit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.01.017
更新日期:2017-02-22 00:00:00
abstract::In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.03.014
更新日期:2017-03-22 00:00:00
abstract::Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.05.039
更新日期:2015-06-03 00:00:00
abstract::In cultured rat embryonic septal nuclei with adjacent basal forebrain, murine interferon-gamma (IFN gamma) produces a striking increase in choline acetyltransferase (ChAT) activity and mRNA. The effect of IFN gamma on cholinergic differentiation is more potent in E14 cultures than in older cultures. IFN gamma does not...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90322-0
更新日期:1994-05-01 00:00:00
abstract::A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90134-1
更新日期:1988-11-01 00:00:00
abstract::Lissencephaly (LIS), denoting a "smooth brain," is characterized by the absence of normal cerebral convolutions with abnormalities of cortical thickness. Pathogenic variants in over 20 genes are associated with LIS. The majority of posterior predominant LIS is caused by pathogenic variants in LIS1 (also known as PAFAH...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.01.027
更新日期:2020-04-22 00:00:00
abstract::To study the effect of cell type-restricted hamster PrP expression on susceptibility to the hamster scrapie agent, we generated transgenic mice using a 1 kb hamster cDNA clone containing the 0.76 kb HPrP open reading frame under control of the neuron-specific enolase promoter. In these mice, expression of HPrP was det...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90105-1
更新日期:1995-11-01 00:00:00
abstract::Two papers in the current issue of Neuron (Izuma et al. and Zink et al.) report that activity in specific regions of the brain, especially the striatum, reflects a common signal of reward in both the economic (e.g., money) and social (e.g., praise and status) domains. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.04.005
更新日期:2008-04-24 00:00:00
abstract::Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.01.024
更新日期:2015-03-04 00:00:00
abstract::Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00179-9
更新日期:2001-01-01 00:00:00
abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.035
更新日期:2019-04-03 00:00:00
abstract::Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.07.020
更新日期:2020-09-09 00:00:00
abstract::Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.032
更新日期:2013-10-30 00:00:00
abstract::Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.042
更新日期:2020-01-08 00:00:00
abstract::The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.05.008
更新日期:2012-06-07 00:00:00
abstract::The intraparietal cortex is involved in the control of visually guided actions, like reach-to-grasp movements, which require extracting the 3D shape and position of objects from 2D retinal images. Using fMRI in behaving monkeys, we investigated the role of the intraparietal cortex in processing stereoscopic informatio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.06.040
更新日期:2007-08-02 00:00:00