Abstract：
:C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that aex-3 defects are presynaptic. In aex-3 mutants, the synaptic vesicle-associated RAB-3 protein aberrantly accumulates in neuronal cell bodies and is reduced in synapse-rich axons. This localization defect is specific to RAB-3, since other synaptic proteins are localized normally in aex-3 mutants. aex-3 encodes a 1409 amino acid protein with strong homology to DENN, a human protein of unknown function. In C. elegans, aex-3 is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release.
journal_name
Neuronjournal_title
Neuronauthors
Iwasaki K,Staunton J,Saifee O,Nonet M,Thomas JHdoi
10.1016/s0896-6273(00)80302-5subject
Has Abstractpub_date
1997-04-01 00:00:00pages
613-22issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80302-5journal_volume
18pub_type
杂志文章相关文献
NEURON文献大全abstract：:The cerebellum is well appreciated to impart speed, smoothness, and precision to skilled movements such as reaching. How these functions are executed by the final output stage of the cerebellum, the cerebellar nuclei, remains unknown. Here, we identify a causal relationship between cerebellar output and mouse reach ki...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.05.007
更新日期：2019-07-17 00:00:00
abstract：:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.01.007
更新日期：2008-04-10 00:00:00
abstract：:Classic studies of spatial attention assumed that its neural and behavioral effects were continuous over time. Recent behavioral studies have instead revealed that spatial attention leads to alternating periods of heightened or diminished perceptual sensitivity. Yet, the neural basis of these rhythmic fluctuations has...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.07.038
更新日期：2018-08-22 00:00:00
abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00143-6
更新日期：2004-04-08 00:00:00
abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80940-x
更新日期：1997-08-01 00:00:00
abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2006.08.019
更新日期：2006-09-07 00:00:00
abstract：:The circadian clock mechanism in the mouse is composed of interlocking transcriptional feedback loops. Two transcription factors, CLOCK and BMAL1, are believed to be essential components of the circadian clock. We have used the Cre-LoxP system to generate whole-animal knockouts of CLOCK and evaluated the resultant cir...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.03.041
更新日期：2006-05-04 00:00:00
abstract：:The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by mot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.11.033
更新日期：2008-01-24 00:00:00
abstract：:While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.04.036
更新日期：2012-06-21 00:00:00
abstract：:In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2008.04.022
更新日期：2008-05-08 00:00:00
abstract：:Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(01)00552-9
更新日期：2001-12-20 00:00:00
abstract：:Brain function is mediated by neural circuit connectivity, and elucidating the role of connections is aided by techniques to block their output. We developed cell-type-selective, reversible synaptic inhibition tools for mammalian neural circuits by leveraging G protein signaling pathways to suppress synaptic vesicle r...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.008
更新日期：2014-05-21 00:00:00
abstract：:Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90081-p
更新日期：1990-10-01 00:00:00
abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90139-5
更新日期：1992-06-01 00:00:00
abstract：:Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.11.004
更新日期：2014-01-22 00:00:00
abstract：:Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.01.029
更新日期：2007-03-01 00:00:00
abstract：:All sensory information is encoded in neural spike trains. It is unknown how the brain utilizes this neural code to drive behavior. Here, we unravel the decoding rules of the brain at the most elementary level by linking behavioral decisions to retinal output signals in a single-photon detection task. A transgenic mou...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.08.005
更新日期：2019-11-06 00:00:00
abstract：:The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unkn...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.08.013
更新日期：2010-10-06 00:00:00
abstract：:The debate over the nature of mechanisms leading to the establishment of synaptic specificity has engaged neuroscientists for the best part of a century. In this issue of Neuron, Balaskas et al. (2019) provide new evidence in favor of the role of positional strategies in the organization of sensory-motor circuits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.05.046
更新日期：2019-06-19 00:00:00
abstract：:Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.041
更新日期：2017-10-11 00:00:00
abstract：:Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90257-7
更新日期：1994-10-01 00:00:00
abstract：:We measured amygdala activity in human volunteers during rapid visual presentations of fearful, happy, and neutral faces using functional magnetic resonance imaging (fMRI). The first experiment involved a fixed order of conditions both within and across runs, while the second one used a fully counterbalanced order in ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80219-6
更新日期：1996-11-01 00:00:00
abstract：:Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2006.11.006
更新日期：2006-11-22 00:00:00
abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90051-5
更新日期：1994-11-01 00:00:00
abstract：:Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally changed its mechanism of acti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.11.004
更新日期：2014-12-17 00:00:00
abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2020.09.006
更新日期：2020-09-23 00:00:00
abstract：:The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.08.020
更新日期：2016-09-21 00:00:00
abstract：:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(02)00910-8
更新日期：2002-09-12 00:00:00
abstract：:Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the ma...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.04.019
更新日期：2016-06-01 00:00:00
abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.12.013
更新日期：2009-01-29 00:00:00
