Abstract：
:Classic studies of spatial attention assumed that its neural and behavioral effects were continuous over time. Recent behavioral studies have instead revealed that spatial attention leads to alternating periods of heightened or diminished perceptual sensitivity. Yet, the neural basis of these rhythmic fluctuations has remained largely unknown. We show that a dynamic interplay within the macaque frontoparietal network accounts for the rhythmic properties of spatial attention. Neural oscillations characterize functional interactions between the frontal eye fields (FEF) and the lateral intraparietal area (LIP), with theta phase (3-8 Hz) coordinating two rhythmically alternating states. The first is defined by FEF-dominated beta-band activity, associated with suppressed attentional shifts, and LIP-dominated gamma-band activity, associated with enhanced visual processing and better behavioral performance. The second is defined by LIP-specific alpha-band activity, associated with attenuated visual processing and worse behavioral performance. Our findings reveal how network-level interactions organize environmental sampling into rhythmic cycles.
journal_name
Neuronjournal_title
Neuronauthors
Fiebelkorn IC,Pinsk MA,Kastner Sdoi
10.1016/j.neuron.2018.07.038subject
Has Abstractpub_date
2018-08-22 00:00:00pages
842-853.e8issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30636-6journal_volume
99pub_type
杂志文章相关文献
NEURON文献大全abstract：:Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.03.009
更新日期：2005-04-07 00:00:00
abstract：:After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00777-8
更新日期：2002-07-18 00:00:00
abstract：:L-Glutamate is regarded as the major excitatory neurotransmitter in the mammalian CNS. However, whether the released transmitter originates from a cytosolic pool or is discharged from synaptic vesicles by exocytosis (vesicle hypothesis) remains controversial. A problem with the general acceptance of the vesicle hypoth...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90240-7
更新日期：1989-12-01 00:00:00
abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.05.021
更新日期：2013-06-05 00:00:00
abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.10.018
更新日期：2004-10-28 00:00:00
abstract：:Real-time activity measurements of genetically identified neuroendocrine vasopressin neurons show they can anticipate osmotic challenges. In this issue of Neuron, Mandelblat-Cerf et al. (2017) show that correlating these results with ongoing behavior and plasma osmolality points to the existence of brain networks that...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.033
更新日期：2017-01-04 00:00:00
abstract：:To survive, humans must estimate their own ability and the abilities of others. We found that, although people estimated their abilities on the basis of their own performance in a rational manner, their estimates of themselves were partly merged with the performance of others. Reciprocally, their ability estimates for...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.06.022
更新日期：2016-07-20 00:00:00
abstract：:Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involve...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.07.008
更新日期：2006-09-07 00:00:00
abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.07.028
更新日期：2007-09-06 00:00:00
abstract：:Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.06.008
更新日期：2008-07-31 00:00:00
abstract：:Recent advances in military-funded neurotechnology and novel opportunities for misusing neurodevices show that the problem of dual use is inherent to neuroscience. This paper discusses how the neuroscience community should respond to these dilemmas and delineates a neuroscience-specific biosecurity framework. This neu...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2017.12.017
更新日期：2018-01-17 00:00:00
abstract：:The mesolimbic system is known to play a role in self-administration of opioids and psychostimulants. Although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80082-3
更新日期：1996-03-01 00:00:00
abstract：:Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(88)90145-6
更新日期：1988-05-01 00:00:00
abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.03.001
更新日期：2010-03-25 00:00:00
abstract：:Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.12.012
更新日期：2013-02-06 00:00:00
abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.12.025
更新日期：2006-02-16 00:00:00
abstract：:LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(02)00759-6
更新日期：2002-07-03 00:00:00
abstract：:The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated th...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.04.040
更新日期：2017-05-17 00:00:00
abstract：:The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.06.002
更新日期：2004-06-24 00:00:00
abstract：:Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80785-0
更新日期：1999-06-01 00:00:00
abstract：:Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.07.034
更新日期：2020-10-28 00:00:00
abstract：:Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90182-5
更新日期：1995-10-01 00:00:00
abstract：:Innate defense behaviors (IDBs) evoked by threatening sensory stimuli are essential for animal survival. Although subcortical circuits are implicated in IDBs, it remains largely unclear whether sensory cortex modulates IDBs and what the underlying neural pathways are. Here, we show that optogenetic silencing of cortic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.03.048
更新日期：2015-05-06 00:00:00
abstract：:The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by mot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.11.033
更新日期：2008-01-24 00:00:00
abstract：:Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)00092-1
更新日期：2000-10-01 00:00:00
abstract：:Although motion-sensitive neurons in macaque middle temporal (MT) area are conventionally characterized using stimuli whose velocity remains constant for 1-3 s, many ecologically relevant stimuli change on a shorter time scale (30-300 ms). We compared neuronal responses to conventional (constant-velocity) and time-var...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80477-8
更新日期：1998-05-01 00:00:00
abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.03.009
更新日期：2009-03-26 00:00:00
abstract：:Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2010.01.016
更新日期：2010-02-25 00:00:00
abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.022
更新日期：2017-07-05 00:00:00
abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.01.001
更新日期：2019-02-20 00:00:00
