Abstract:
:Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over 24-48 hr, coexpressing BDNF elicited dramatic sprouting of basal dendrites, accompanied by a regression of dendritic spines. Compared to GFP-transfected controls, the newly formed dendrites and spines were highly unstable. Experiments utilizing Trk receptor bodies, K252a, and overexpression of nerve growth factor (NGF) demonstrated that these effects were mediated by secreted BDNF interacting with extracellular TrkB receptors. Thus, BDNF induces structural instability in dendrites and spines, which, when restricted to particular portions of a dendritic arbor, may help translate activity patterns into specific morphological changes.
journal_name
Neuronjournal_title
Neuronauthors
Horch HW,Krüttgen A,Portbury SD,Katz LCdoi
10.1016/s0896-6273(00)80785-0subject
Has Abstractpub_date
1999-06-01 00:00:00pages
353-64issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80785-0journal_volume
23pub_type
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