Abstract:
:Incoming stimuli are encoded collectively by populations of cortical neurons, which transmit information by using a neural code thought to be predominantly redundant. Redundant coding is widely believed to reflect a design choice whereby neurons with overlapping receptive fields sample environmental stimuli to convey similar information. Here, we performed multi-electrode laminar recordings in awake monkey V1 to report significant synergistic interactions between nearby neurons within a cortical column. These interactions are clustered non-randomly across cortical layers to form synergy and redundancy hubs. Homogeneous sub-populations comprising synergy hubs decode stimulus information significantly better compared to redundancy hubs or heterogeneous sub-populations. Mechanistically, synergistic interactions emerge from the stimulus dependence of correlated activity between neurons. Our findings suggest a refinement of the prevailing ideas regarding coding schemes in sensory cortex: columnar populations can efficiently encode information due to synergistic interactions even when receptive fields overlap and shared noise between cells is high.
journal_name
Neuronjournal_title
Neuronauthors
Nigam S,Pojoga S,Dragoi Vdoi
10.1016/j.neuron.2019.07.006subject
Has Abstractpub_date
2019-10-23 00:00:00pages
402-411.e4issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(19)30632-4journal_volume
104pub_type
杂志文章相关文献
NEURON文献大全abstract::Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.001
更新日期:2005-07-21 00:00:00
abstract::The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca(2+) imaging from genetica...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.06.021
更新日期:2015-07-15 00:00:00
abstract::The mechanisms controlling the transition from neurogenesis to gliogenesis in the vertebrate CNS are incompletely understood. We identified a family of transcription factors, called NFI genes, which are induced throughout the spinal cord ventricular zone (VZ) concomitantly with the induction of GLAST, an early marker ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.11.019
更新日期:2006-12-21 00:00:00
abstract::Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.05.021
更新日期:2008-07-31 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00143-6
更新日期:2004-04-08 00:00:00
abstract::Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor re...
journal_title:Neuron
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuron.2009.10.018
更新日期:2009-12-10 00:00:00
abstract::Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.05.022
更新日期:2015-06-17 00:00:00
abstract::The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.023
更新日期:2006-10-19 00:00:00
abstract::Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.02.004
更新日期:2006-03-16 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are membrane spanning proteins with intrinsic kinase activity. Although these receptors are known to be involved in proliferation and differentiation of cells, their roles in regulating central synaptic transmission are largely unknown. In CA1 pyramidal neurons, activation of D2 class ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00859-0
更新日期:2002-09-12 00:00:00
abstract::It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.12.025
更新日期:2007-01-18 00:00:00
abstract::Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.12.039
更新日期:2017-01-18 00:00:00
abstract::Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.06.012
更新日期:2019-09-04 00:00:00
abstract::Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.09.006
更新日期:2008-09-25 00:00:00
abstract::Natural vision often involves recognizing objects from partial information. Recognition of objects from parts presents a significant challenge for theories of vision because it requires spatial integration and extrapolation from prior knowledge. Here we recorded intracranial field potentials of 113 visually selective ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.06.017
更新日期:2014-08-06 00:00:00
abstract::Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.03.017
更新日期:2012-06-07 00:00:00
abstract::In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.05.021
更新日期:2013-06-05 00:00:00
abstract::The process by which neural circuitry in the brain plans and executes movements is not well understood. Until recently, most available data were limited either to single-neuron electrophysiological recordings or to measures of aggregate field or metabolism. Neither approach reveals how individual neurons' activities a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.05.047
更新日期:2011-08-11 00:00:00
abstract::In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.12.007
更新日期:2018-01-17 00:00:00
abstract::Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90131-6
更新日期:1988-11-01 00:00:00
abstract::To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.12.029
更新日期:2013-01-23 00:00:00
abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00424-x
更新日期:2001-09-13 00:00:00
abstract::We present a modular approach for analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and denoise and deconvolve the spiking activity from the slow dynamics of the calcium indicator. Our approach ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.037
更新日期:2016-01-20 00:00:00
abstract::Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.02.012
更新日期:2010-03-11 00:00:00
abstract::Local neuronal networks that are responsible for walking are poorly characterized in mammals. Using an innovative approach to identify interneuron inputs onto motorneuron populations in a neonatal rodent spinal cord preparation, we have investigated the network responsible for left-right coordination of the hindlimbs....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00353-2
更新日期:2003-06-19 00:00:00
abstract::Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00826-7
更新日期:2002-08-15 00:00:00
abstract::Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80548-6
更新日期:1998-08-01 00:00:00
abstract::The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into opening of its central pore. Here we present the first high-resolution structure of the receptor type found in muscle-endplate membrane and in the muscle-derived e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.03.012
更新日期:2020-06-17 00:00:00
abstract::We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90238-m
更新日期:1993-01-01 00:00:00
abstract::Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.03.019
更新日期:2005-04-21 00:00:00