Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system.

abstract：:Chen et al present data describing millisecond interactions in a human hyperdirect pathway that connects the inferior frontal gyrus and the subthalamic nucleus. They study this circuit during a stop-signal task in the context of inhibitory control. ...

journal_title：Neuron

authors： Narayanan NS,Wessel JR,Greenlee JDW

更新日期：2020-05-20 00:00:00

abstract：:A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...

journal_title：Neuron

authors： Zhang Y,Narayan S,Geiman E,Lanuza GM,Velasquez T,Shanks B,Akay T,Dyck J,Pearson K,Gosgnach S,Fan CM,Goulding M

更新日期：2008-10-09 00:00:00

abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...

journal_title：Neuron

authors： Baden T,Schubert T,Chang L,Wei T,Zaichuk M,Wissinger B,Euler T

更新日期：2013-12-04 00:00:00

abstract：:Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...

journal_title：Neuron

authors： Kaneko M,Stellwagen D,Malenka RC,Stryker MP

更新日期：2008-06-12 00:00:00

abstract：:The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...

journal_title：Neuron

authors： Eisen JS

更新日期：1992-02-01 00:00:00

abstract：:Oxygen (O₂) and carbon dioxide (CO₂) levels vary in different environments and locally fluctuate during respiration and photosynthesis. Recent studies in diverse animals have identified sensory neurons that detect these external variations and direct a variety of behaviors. Detection allows animals to stay within a pr...

journal_title：Neuron

authors： Scott K

更新日期：2011-01-27 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an ea...

journal_title：Neuron

authors： Ruegsegger C,Stucki DM,Steiner S,Angliker N,Radecke J,Keller E,Zuber B,Rüegg MA,Saxena S

更新日期：2016-01-06 00:00:00

abstract：:In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3), postmortem samples of hippocampus from AD and control donors were examined ...

journal_title：Neuron

authors： Phillips HS,Hains JM,Armanini M,Laramee GR,Johnson SA,Winslow JW

更新日期：1991-11-01 00:00:00

abstract：:Tau protein undergoes a shift in its molecular mass and its electrophoretic complexity during early postnatal development. We have sequenced a tau cDNA from an adult rat brain expression library and have found two inserted sequences. One of these inserts predicts a fourth repeated sequence homologous to the other thre...

journal_title：Neuron

authors： Kosik KS,Orecchio LD,Bakalis S,Neve RL

更新日期：1989-04-01 00:00:00

abstract：:During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...

journal_title：Neuron

authors： Mandai K,Reimert DV,Ginty DD

更新日期：2014-07-02 00:00:00

abstract：:Today we are witnessing a new science of placebo, a complex discipline that encompasses several experimental approaches and translational implications. Modern neurobiological tools have been used to answer important questions in placebo research, such as the top-down modulation of sensory and motor systems as well as ...

journal_title：Neuron

authors： Benedetti F

更新日期：2014-11-05 00:00:00

abstract：:Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by...

journal_title：Neuron

authors： Adelman JP,Shen KZ,Kavanaugh MP,Warren RA,Wu YN,Lagrutta A,Bond CT,North RA

更新日期：1992-08-01 00:00:00

abstract：:Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during active whisker sensation using whole-cell recordings from layer 2/3...

journal_title：Neuron

authors： Crochet S,Poulet JF,Kremer Y,Petersen CC

更新日期：2011-03-24 00:00:00

abstract：:Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...

journal_title：Neuron

authors： Wang Q,Chiu SL,Koropouli E,Hong I,Mitchell S,Easwaran TP,Hamilton NR,Gustina AS,Zhu Q,Ginty DD,Huganir RL,Kolodkin AL

更新日期：2017-12-06 00:00:00

abstract：:Whether cognitive representations are better conceived as language-based, symbolic representations or perceptually related, analog representations is a subject of debate. If cognitive processes parallel perceptual processes, then fundamental psychophysical laws should hold for each. To test this, we analyzed both beha...

journal_title：Neuron

authors： Nieder A,Miller EK

更新日期：2003-01-09 00:00:00

abstract：:Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of contex...

journal_title：Neuron

authors： Gibson GD,Prasad AA,Jean-Richard-Dit-Bressel P,Yau JOY,Millan EZ,Liu Y,Campbell EJ,Lim J,Marchant NJ,Power JM,Killcross S,Lawrence AJ,McNally GP

更新日期：2018-05-02 00:00:00

abstract：:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...

journal_title：Neuron

authors： Wu YE,Huo L,Maeder CI,Feng W,Shen K

更新日期：2013-06-19 00:00:00

abstract：:The mesolimbic system is known to play a role in self-administration of opioids and psychostimulants. Although morphine and cocaine act by separate cellular mechanisms initially, the present study describes a common change in synaptic regulation of dopamine cells in the ventral tegmental area 1 week after termination ...

journal_title：Neuron

authors： Bonci A,Williams JT

更新日期：1996-03-01 00:00:00

abstract：:The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...

journal_title：Neuron

authors： Weissbourd B,Ren J,DeLoach KE,Guenthner CJ,Miyamichi K,Luo L

更新日期：2014-08-06 00:00:00

abstract：:The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slow oscillation in thalamocortical (TC) neurons is largely a passive reflection of neocortical activity. Here we show, however, tha...

journal_title：Neuron

authors： Hughes SW,Cope DW,Blethyn KL,Crunelli V

更新日期：2002-03-14 00:00:00

abstract：:Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...

journal_title：Neuron

authors： Chini M,Pöpplau JA,Lindemann C,Carol-Perdiguer L,Hnida M,Oberländer V,Xu X,Ahlbeck J,Bitzenhofer SH,Mulert C,Hanganu-Opatz IL

更新日期：2020-01-08 00:00:00

abstract：:AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...

journal_title：Neuron

authors： Greger IH,Khatri L,Kong X,Ziff EB

更新日期：2003-11-13 00:00:00

abstract：:We have used immunogold electron microscopy to study the organization of the acetylcholine receptor, 43 kd protein, voltage-sensitive Na+ channel, and ankyrin in the postsynaptic membrane of the rat neuromuscular junction. The acetylcholine receptor and the 43 kd protein are concentrated at the crests of the postsynap...

journal_title：Neuron

authors： Flucher BE,Daniels MP

更新日期：1989-08-01 00:00:00

abstract：:The concept of the CNS as an immune-privileged organ has led to a common misunderstanding that it is not an active immunological organ, guarded from its surroundings by the blood-brain barrier (BBB). Recent advances in this field clearly demonstrate that the CNS is a highly immunologically active organ, with complex i...

journal_title：Neuron

authors： Lampron A,Elali A,Rivest S

更新日期：2013-04-24 00:00:00

abstract：:Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal...

journal_title：Neuron

authors： Stobrawa SM,Breiderhoff T,Takamori S,Engel D,Schweizer M,Zdebik AA,Bösl MR,Ruether K,Jahn H,Draguhn A,Jahn R,Jentsch TJ

更新日期：2001-01-01 00:00:00

abstract：:The discovery of SNCA mutations pathogenic for autosomal-dominant Lewy body Parkinson's disease (PD) in 1997 heralded a revolution in understanding the molecular and genetic basis of PD. Indeed, it now is clear that Lewy body PD is one of many neurodegenerative parkinsonian disorders that result from nigrostriatal deg...

journal_title：Neuron

authors： Forman MS,Lee VM,Trojanowski JQ

更新日期：2005-08-18 00:00:00

abstract：:Commissural axons are attracted to the midline intermediate target by chemoattractants, but upon crossing the midline they switch off responsiveness to attractants and switch on responsiveness to midline repellents, which expel the axons from the midline and enable them to move on. Here we show that midline exit also ...

journal_title：Neuron

authors： Gore BB,Wong KG,Tessier-Lavigne M

更新日期：2008-02-28 00:00:00

abstract：:The identification of surface proteins restricted to subsets of embryonic axons and growth cones may provide information on the mechanisms underlying axon fasciculation and pathway selection in the vertebrate nervous system. We describe here the characterization of a 135 kd cell surface glycoprotein, TAG-1, that is ex...

journal_title：Neuron

authors： Dodd J,Morton SB,Karagogeos D,Yamamoto M,Jessell TM

更新日期：1988-04-01 00:00:00

abstract：:mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...

journal_title：Neuron

authors： Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RA

更新日期：1991-08-01 00:00:00

abstract：:A multitude of synaptic proteins interact at the active zones of nerve terminals to achieve the high temporal precision of neurotransmitter release in synchrony with action potentials. Though synaptotagmin has been recognized as the Ca2+ sensor for synchronous release, it may have additional roles of action. We addres...

journal_title：Neuron

authors： Young SM Jr,Neher E

更新日期：2009-08-27 00:00:00