Abstract：
:Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions were either biased in favor of a single alternative (A/ approximately A decisions) or taken without bias toward either choice (A/B decisions). Extrastriate and anterior temporal lobe regions were more active during A/ approximately A than A/B decisions, suggesting multiple representations of prior expectations within the visual hierarchy. Forward connectivity was increased when expected and observed perception diverged ("prediction error" signals), whereas prior expectations fed backward from higher to lower regions. Finally, the coincidence between expected and observed perception activated orbital prefrontal regions, perhaps reflecting the reinforcement of prior expectations. These data support computational and quantitative models proposing that a visual percept emerges from converging bottom-up and top-down signals.
journal_name
Neuronjournal_title
Neuronauthors
Summerfield C,Koechlin Edoi
10.1016/j.neuron.2008.05.021subject
Has Abstractpub_date
2008-07-31 00:00:00pages
336-47issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00456-Xjournal_volume
59pub_type
杂志文章相关文献
NEURON文献大全abstract：:Na+ channels are present at high density in squid giant axon but are absent from its somata in the giant fiber lobe (GFL) of the stellate ganglion. GFL cells dispersed in vitro maintain growing axons and develop a Na+ channel distribution similar to that in vivo. Tunicamycin, a glycosylation inhibitor, selectively dis...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90220-a
更新日期：1990-11-01 00:00:00
abstract：:Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including lear...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.08.032
更新日期：2011-10-20 00:00:00
abstract：:Neuroscience is an exciting and vibrant field, but building an academic career is not always easy. What are critical success indicators? Which tools help talented young neuroscientists conquer the challenges? In this NeuroView, we discuss instruments and steps that can help people progress through the ranks. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.04.002
更新日期：2015-05-06 00:00:00
abstract：:In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD. ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2017.02.044
更新日期：2017-03-08 00:00:00
abstract：:Many high threshold, voltage-gated Ca2+ channels, including the dihydropyridine-sensitive class (L-type), inactivate in response not only to voltage, but also to entry of Ca2+. Despite the physiological importance of this Ca(2+)-sensitive inactivation, its molecular mechanism is understood only in broad outline. We no...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90446-4
更新日期：1994-06-01 00:00:00
abstract：:In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.09.046
更新日期：2017-10-11 00:00:00
abstract：:Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.02.016
更新日期：2015-03-18 00:00:00
abstract：:In this issue of Neuron, Kremeyer et al. describe a gain-of-function mutation of TRPA1 that produces a painful disorder, familial episodic pain syndrome. This discovery enlarges the list of ion channels that, when mutated, produce pain. The growing universe of "channelopathic pain" presents some interesting overarchin...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2010.05.029
更新日期：2010-06-10 00:00:00
abstract：:In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.03.014
更新日期：2017-03-22 00:00:00
abstract：:Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.01.002
更新日期：2014-02-19 00:00:00
abstract：:Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.03.010
更新日期：2007-04-05 00:00:00
abstract：:Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 l...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2004.12.007
更新日期：2004-12-16 00:00:00
abstract：:In humans the hippocampus is required for episodic memory, which extends into the spatial and temporal domains. Work on the rodent hippocampus has shown that NMDA receptor (NMDAR) -mediated plasticity is essential for spatial memory. Here, we have examined whether hippocampal NMDARs are also needed for temporal memory...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80909-5
更新日期：2000-02-01 00:00:00
abstract：:In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drink...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.12.028
更新日期：2011-01-27 00:00:00
abstract：:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.12.017
更新日期：2011-02-10 00:00:00
abstract：:L-Glutamate is regarded as the major excitatory neurotransmitter in the mammalian CNS. However, whether the released transmitter originates from a cytosolic pool or is discharged from synaptic vesicles by exocytosis (vesicle hypothesis) remains controversial. A problem with the general acceptance of the vesicle hypoth...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90240-7
更新日期：1989-12-01 00:00:00
abstract：:Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80689-3
更新日期：1999-01-01 00:00:00
abstract：:Voltage-gated calcium channels are well characterized at neuronal somata but less thoroughly understood at the presynaptic terminal where they trigger transmitter release. In order to elucidate how the intrinsic properties of presynaptic calcium channels influence synaptic function, we have made direct recordings of t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81017-x
更新日期：1998-04-01 00:00:00
abstract：:Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefin...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.04.047
更新日期：2014-06-18 00:00:00
abstract：:Perceptual decisions require the transformation of raw sensory inputs into cortical representations suitable for stimulus discrimination. One of the best-known examples of this transformation involves the middle temporal area (MT) of the primate visual cortex. Area MT provides a robust representation of stimulus motio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.024
更新日期：2017-07-19 00:00:00
abstract：:Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.02.026
更新日期：2013-04-24 00:00:00
abstract：:Adolescence is often described as a period of heightened reactivity to emotions paired with reduced regulatory capacities, a combination suggested to contribute to risk-taking and susceptibility to peer influence during puberty. However, no longitudinal research has definitively linked these behavioral changes to unde...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.02.019
更新日期：2011-03-10 00:00:00
abstract：:Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00179-9
更新日期：2001-01-01 00:00:00
abstract：:We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and GluR6. Of these, we show that both GRIP and PICK1 interactions are required to maintain KAR-mediated synaptic function at mossy fiber-CA3 synapses. In a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)01191-1
更新日期：2003-02-20 00:00:00
abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.10.018
更新日期：2004-10-28 00:00:00
abstract：:Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.02.012
更新日期：2010-03-11 00:00:00
abstract：:RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.07.022
更新日期：2004-08-19 00:00:00
abstract：:Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.03.021
更新日期：2018-04-18 00:00:00
abstract：:Brain areas in the frontal lobe have been implicated in behavioral flexibility and control. The study by Johnston et al. in this issue of Neuron provides novel insights into the roles of the prefrontal and anterior cingulate cortices in controlling behavior. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2007.01.015
更新日期：2007-02-01 00:00:00
abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.07.019
更新日期：2018-07-25 00:00:00
