Abstract：
:Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including learning, but the neurotransmitters released by the intrinsic Kenyon cells (KCs) remain unknown. Likewise, KCs do not express a known vesicular transporter. We report the identification of a novel Drosophila gene portabella (prt) that is structurally similar to known vesicular transporters. Both larval and adult brains express PRT in the KCs of the MBs. Additional PRT cells project to the central complex and optic ganglia. prt mutation causes an olfactory learning deficit and an unusual defect in the male's position during copulation that is rescued by expression in KCs. Because prt is expressed in neurons that lack other known vesicular transporters or neurotransmitters, it may define a previously unknown neurotransmitter system responsible for sexual behavior and a component of olfactory learning.
journal_name
Neuronjournal_title
Neuronauthors
Brooks ES,Greer CL,Romero-Calderón R,Serway CN,Grygoruk A,Haimovitz JM,Nguyen BT,Najibi R,Tabone CJ,de Belle JS,Krantz DEdoi
10.1016/j.neuron.2011.08.032subject
Has Abstractpub_date
2011-10-20 00:00:00pages
316-29issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00794-Xjournal_volume
72pub_type
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