Polarized domains of myelinated axons.

abstract：:The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function. ...

journal_title：Neuron

authors： West AE

更新日期：2012-01-12 00:00:00

abstract：:Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of "resting-state" neuronal activity. The temporal correlations among these fluctuations across the brain are interpreted as "functional connections" for maps and neurological diagnostics. Ultra-slow varia...

journal_title：Neuron

authors： Drew PJ,Mateo C,Turner KL,Yu X,Kleinfeld D

更新日期：2020-09-09 00:00:00

abstract：:Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body ...

journal_title：Neuron

authors： Kelleher RJ 3rd,Govindarajan A,Tonegawa S

更新日期：2004-09-30 00:00:00

abstract：:We describe the extent to which presynaptic structures at the embryonic neuromuscular junction of Drosophila can form in mutants where development of postsynaptic somatic muscles is affected. Although twist mutant embryos lack mesoderm, motor axons still grow out of the CNS and form morphologically normal presynaptic ...

journal_title：Neuron

authors： Prokop A,Landgraf M,Rushton E,Broadie K,Bate M

更新日期：1996-10-01 00:00:00

abstract：:The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...

journal_title：Neuron

authors： Tabone CJ,Ramaswami M

更新日期：2012-06-07 00:00:00

abstract：:While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...

journal_title：Neuron

authors： Frade JM,Barde YA

更新日期：1998-01-01 00:00:00

abstract：:Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...

journal_title：Neuron

authors： Taniguchi M,Carreira MB,Smith LN,Zirlin BC,Neve RL,Cowan CW

更新日期：2012-01-12 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schiz...

journal_title：Neuron

authors： Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

更新日期：2014-01-22 00:00:00

abstract：:Visual experience before eye-opening is not usually thought to have any developmental significance. Here we show that naturalistic visual stimuli presented through unopened eyelids robustly activate neurons in the ferret dorsal lateral geniculate nucleus. Further, dark-rearing prior to natural eye-opening has striking...

journal_title：Neuron

authors： Akerman CJ,Smyth D,Thompson ID

更新日期：2002-12-05 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look tow...

journal_title：Neuron

authors： Johnston K,Levin HM,Koval MJ,Everling S

更新日期：2007-02-01 00:00:00

abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

journal_title：Neuron

authors： Jackman SL,Regehr WG

更新日期：2017-05-03 00:00:00

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00

abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

journal_title：Neuron

authors： Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

更新日期：2007-09-20 00:00:00

abstract：:Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification of developing retinotectal circuits via spike timing-dependent plasticity (STDP). Pairing light stimuli with spiking of the tectal cell induced persistent enha...

journal_title：Neuron

authors： Mu Y,Poo MM

更新日期：2006-04-06 00:00:00

abstract：:Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...

journal_title：Neuron

authors： Gilbert CD,Sigman M,Crist RE

更新日期：2001-09-13 00:00:00

abstract：:In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...

journal_title：Neuron

authors： Catanese J,van der Meer M

更新日期：2013-06-05 00:00:00

abstract：:We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...

journal_title：Neuron

authors： Hasson U,Harel M,Levy I,Malach R

更新日期：2003-03-27 00:00:00

abstract：:Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...

journal_title：Neuron

authors： Thompson WJ

更新日期：2001-08-16 00:00:00

abstract：:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...

journal_title：Neuron

authors： Wadiche JI,Arriza JL,Amara SG,Kavanaugh MP

更新日期：1995-05-01 00:00:00

abstract：:Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...

journal_title：Neuron

authors： Peelen MV,Wiggett AJ,Downing PE

更新日期：2006-03-16 00:00:00

abstract：:Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...

journal_title：Neuron

authors： Kim E,Huh JR

更新日期：2019-11-20 00:00:00

abstract：:Mutations in a synaptic organizing pathway contribute to autism. Autism-associated mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are thought to reduce excitatory/inhibitory transmission. However, we show that mutation of Mdga2 elevates excitatory transmission, and that MDGA2 blocks n...

journal_title：Neuron

authors： Connor SA,Ammendrup-Johnsen I,Chan AW,Kishimoto Y,Murayama C,Kurihara N,Tada A,Ge Y,Lu H,Yan R,LeDue JM,Matsumoto H,Kiyonari H,Kirino Y,Matsuzaki F,Suzuki T,Murphy TH,Wang YT,Yamamoto T,Craig AM

更新日期：2016-09-07 00:00:00

abstract：:Improvement in motor skill performance is known to continue for at least 24 hr following training, yet the relative contributions of time spent awake and asleep are unknown. Here we provide evidence that a night of sleep results in a 20% increase in motor speed without loss of accuracy, while an equivalent period of t...

journal_title：Neuron

authors： Walker MP,Brakefield T,Morgan A,Hobson JA,Stickgold R

更新日期：2002-07-03 00:00:00

abstract：:Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negat...

journal_title：Neuron

authors： Luo L,Wen Q,Ren J,Hendricks M,Gershow M,Qin Y,Greenwood J,Soucy ER,Klein M,Smith-Parker HK,Calvo AC,Colón-Ramos DA,Samuel AD,Zhang Y

更新日期：2014-06-04 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00

abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...

journal_title：Neuron

authors： Levine JN,Gu Y,Cang J

更新日期：2015-05-20 00:00:00

abstract：:Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K(+) current (IKmech) that governs mechanical threshold and adaptation of distinct populations of mechanoreceptors. Toxin profiling and transgenic mouse studies indicate that IKmech is c...

journal_title：Neuron

authors： Hao J,Padilla F,Dandonneau M,Lavebratt C,Lesage F,Noël J,Delmas P

更新日期：2013-03-06 00:00:00

abstract：:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...

journal_title：Neuron

authors： Xiang JZ,Brown MW

更新日期：2004-06-10 00:00:00