Abstract:
:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the period over which stimuli had to be remembered extended to 24 hr. Such responses occurred frequently in ventromedial, orbitofrontal, and anterior cingulate but not dorsolateral prefrontal cortex. Prefrontal information processing, as indicated by the response latencies, started after that in inferior temporal cortex and might be related to retrieval processes, as responses were typically larger for familiar than for novel stimuli.
journal_name
Neuronjournal_title
Neuronauthors
Xiang JZ,Brown MWdoi
10.1016/j.neuron.2004.05.013subject
Has Abstractpub_date
2004-06-10 00:00:00pages
817-29issue
5eissn
0896-6273issn
1097-4199pii
S089662730400296Xjournal_volume
42pub_type
杂志文章相关文献
NEURON文献大全abstract::Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.05.021
更新日期:2008-07-31 00:00:00
abstract::In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.01.021
更新日期:2015-02-04 00:00:00
abstract::The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00364-7
更新日期:2003-06-19 00:00:00
abstract::We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90166-o
更新日期:1993-04-01 00:00:00
abstract::In this issue of Neuron, Moehle et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine in an output nucleus of the basal ganglia. They provide intracellular, anatomical, and network-level mechanisms for this cholinergic-dopaminergic interplay. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2017.12.014
更新日期:2017-12-20 00:00:00
abstract::Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.042
更新日期:2019-11-20 00:00:00
abstract::Live imaging studies in mice show that adult-born oligodendrocytes and myelin are remarkably stable. Neural activity enhances oligodendrocyte integration, arguing that internode addition rather than alteration represents the mechanism for any experience-dependent cortical myelination changes that might underpin learni...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.05.005
更新日期:2018-05-16 00:00:00
abstract::Many high threshold, voltage-gated Ca2+ channels, including the dihydropyridine-sensitive class (L-type), inactivate in response not only to voltage, but also to entry of Ca2+. Despite the physiological importance of this Ca(2+)-sensitive inactivation, its molecular mechanism is understood only in broad outline. We no...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90446-4
更新日期:1994-06-01 00:00:00
abstract::Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00789-x
更新日期:2003-12-18 00:00:00
abstract::Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00038-8
更新日期:2004-02-05 00:00:00
abstract::The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.02.047
更新日期:2017-05-03 00:00:00
abstract::Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90340-w
更新日期:1993-03-01 00:00:00
abstract::Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00147-1
更新日期:2000-12-01 00:00:00
abstract::Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.01.041
更新日期:2018-02-07 00:00:00
abstract::Metabotropic glutamate receptors (mGluRs) coupled to phosphoinositide hydrolysis desensitize in response to prolonged or repeated agonist exposure, and evidence suggests that this involves activation of protein kinase C (PKC). The present studies were undertaken to determine if cloned mGluR5 undergoes similar PKC-medi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80442-0
更新日期:1998-01-01 00:00:00
abstract::Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80254-8
更新日期:1996-12-01 00:00:00
abstract::The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.02.023
更新日期:2014-03-05 00:00:00
abstract::When faced with a crowded visual scene, observers must selectively attend to behaviorally relevant objects to avoid sensory overload. Often this selection process is guided by prior knowledge of a target-defining feature (e.g., the color red when looking for an apple), which enhances the firing rate of visual neurons ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.06.015
更新日期:2007-07-19 00:00:00
abstract::Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.10.046
更新日期:2018-12-19 00:00:00
abstract::The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.06.002
更新日期:2018-07-11 00:00:00
abstract::We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90058-n
更新日期:1990-03-01 00:00:00
abstract::The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the pre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.03.010
更新日期:2019-05-22 00:00:00
abstract::The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.014
更新日期:2004-07-08 00:00:00
abstract::Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during active whisker sensation using whole-cell recordings from layer 2/3...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.02.022
更新日期:2011-03-24 00:00:00
abstract::Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.08.024
更新日期:2017-09-13 00:00:00
abstract::Evolutionary conservation of members of the NGF family in vertebrates was studied by DNA sequence analysis of PCR fragments for NGF, BDNF, and NT-3 from human, rat, chicken, viper, Xenopus, salmon, and ray. The results showed that the three factors are highly conserved from fishes to mammals. Phylogenetic trees reflec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90180-8
更新日期:1991-05-01 00:00:00
abstract::In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80940-x
更新日期:1997-08-01 00:00:00
abstract::RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.07.022
更新日期:2004-08-19 00:00:00
abstract::We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.01.026
更新日期:2020-03-04 00:00:00
abstract::The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2012.06.002
更新日期:2012-06-21 00:00:00