Abstract:
:Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality.
journal_name
Neuronjournal_title
Neuronauthors
Shalom S,Zaidel Adoi
10.1016/j.neuron.2018.01.041subject
Has Abstractpub_date
2018-02-07 00:00:00pages
484-487issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(18)30066-7journal_volume
97pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involve...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.008
更新日期:2006-09-07 00:00:00
abstract::Neurons compensate their synaptic strengths to global changes in network activity. In this issue of Neuron, Lee et al. (2013) provide evidence in mature hippocampal networks that this homeostatic plasticity is achieved uniquely at the mossy fiber synapses on CA3 neurons. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.12.024
更新日期:2013-01-09 00:00:00
abstract::Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00500-2
更新日期:2003-08-14 00:00:00
abstract::Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90239-2
更新日期:1995-01-01 00:00:00
abstract::In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.003
更新日期:2019-10-23 00:00:00
abstract::bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between th...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00329-5
更新日期:2003-06-05 00:00:00
abstract::Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90222-8
更新日期:1995-04-01 00:00:00
abstract::Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.009
更新日期:2014-05-07 00:00:00
abstract::Involvement of the cAMP cascade in Drosophila learning and memory is suggested by the aberrant behavioral phenotypes of the mutants dunce (cAMP phosphodiesterase) and rutabaga (adenylyl cyclase). Line DCO581, isolated via an enhancer detector screen for genes preferentially expressed in the mushroom bodies, contains a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90178-t
更新日期:1993-08-01 00:00:00
abstract::Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.042
更新日期:2016-07-20 00:00:00
abstract::The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.04.019
更新日期:2006-05-18 00:00:00
abstract::Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.020
更新日期:2017-06-21 00:00:00
abstract::We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90139-7
更新日期:1990-06-01 00:00:00
abstract::Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first combined with modernized light-sheet microscopy a decade ago, the performance of both tec...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.03.004
更新日期:2020-05-06 00:00:00
abstract::Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90087-v
更新日期:1990-10-01 00:00:00
abstract::The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin. However, the contribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated directly. Combining prim...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.12.011
更新日期:2014-02-19 00:00:00
abstract::In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.01.025
更新日期:2017-02-08 00:00:00
abstract::Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81095-8
更新日期:1999-02-01 00:00:00
abstract::Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explain local rhythmic behaviors. In C. elegans, we report that proprioception within the motor circuit is responsible for propag...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.039
更新日期:2012-11-21 00:00:00
abstract::The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80270-6
更新日期:1997-02-01 00:00:00
abstract::Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.03.025
更新日期:2011-06-09 00:00:00
abstract::Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.06.009
更新日期:2004-06-24 00:00:00
abstract::The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.04.005
更新日期:2009-04-16 00:00:00
abstract::Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an exp...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80801-6
更新日期:1999-07-01 00:00:00
abstract::We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90297-d
更新日期:1991-09-01 00:00:00
abstract::Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90211-2
更新日期:1995-04-01 00:00:00
abstract::As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00370-2
更新日期:2003-07-03 00:00:00
abstract::Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.07.021
更新日期:2019-08-07 00:00:00
abstract::In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.07.016
更新日期:2007-08-02 00:00:00
abstract::Screens for genes that orchestrate neural circuit formation in mammals have been hindered by practical constraints of germline mutagenesis. To overcome these limitations, we combined RNA-seq with somatic CRISPR mutagenesis to study synapse development in the mouse retina. Here synapses occur between cellular layers, f...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.03.004
更新日期:2018-04-04 00:00:00