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Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory.

Abstract：

:Involvement of the cAMP cascade in Drosophila learning and memory is suggested by the aberrant behavioral phenotypes of the mutants dunce (cAMP phosphodiesterase) and rutabaga (adenylyl cyclase). Line DCO581, isolated via an enhancer detector screen for genes preferentially expressed in the mushroom bodies, contains a transposon in the first exon of the catalytic subunit gene (DCO) of protein kinase A (PKA). RNA in situ hybridization and immunohistochemistry show that DCO is preferentially expressed in the mushroom bodies. The DCO581 insertion and an independently isolated hypomorphic allele (DCOB10) each produce homozygous lethality and a 40% decrease in PKA activity in heterozygotes. This decrease has mild effects on learning but no effect on memory. However, the 80% reduction in activity obtained by constructing heteroallelic yet viable DCO581/DCOB10 animals results in a dramatic learning and memory deficit. These results suggest that PKA plays a crucial role in the cAMP cascade in mushroom bodies to mediate learning and memory processes.

journal_name

Neuron

journal_title

Neuron

authors

Skoulakis EM,Kalderon D,Davis RL

doi

10.1016/0896-6273(93)90178-t

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

197-208

issue

2

eissn

0896-6273

issn

1097-4199

pii

0896-6273(93)90178-T

journal_volume

11

pub_type

杂志文章

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