Abstract:
:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical pathways underlying the etiology of sporadic PD. Mutations in the parkin gene causal of autosomal recessive juvenile parkinsonism highlight that ubiquitin-mediated proteolysis may play an important role in the pathobiology of PD.
journal_name
Neuronjournal_title
Neuronauthors
Giasson BI,Lee VMdoi
10.1016/s0896-6273(01)00439-1subject
Has Abstractpub_date
2001-09-27 00:00:00pages
885-8issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00439-1journal_volume
31pub_type
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