Abstract:
:We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for its activity. We further demonstrated that, both in vitro and in vivo, neural stem cells undergoing cell division are immunopositive for cystatin C. Finally, we showed in vivo functional activity of CCg by demonstrating that the combined delivery of FGF-2 and CCg to the adult dentate gyrus stimulated neurogenesis. We propose that the process of neurogenesis is controlled by the cooperation between trophic factors and autocrine/paracrine cofactors, of which CCg is a prototype.
journal_name
Neuronjournal_title
Neuronauthors
Taupin P,Ray J,Fischer WH,Suhr ST,Hakansson K,Grubb A,Gage FHdoi
10.1016/s0896-6273(00)00119-7subject
Has Abstractpub_date
2000-11-01 00:00:00pages
385-97issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(00)00119-7journal_volume
28pub_type
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